Effects of Antidepressant Treatment on the Quality of Daily Life

Barge-Schaapveld, Daniela Q.C.M.; Nicolson, Nancy A.

doi:10.4088/jcp.v63n0603

Cited by 82 publications

(82 citation statements)

References 33 publications

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“…Eighty-three patients with a DSM-IV diagnosis of current major depressive disorder were recruited in eight primary care practices in the Netherlands (for full details concerning diagnosis and screening, see Barge-Schaapveld and Nicolson (2002)). Data were collected in the period between 1995 and 1996.…”

Section: Methods Subjectsmentioning

confidence: 99%

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Reduced Stress-Sensitivity or Increased Reward Experience: The Psychological Mechanism of Response to Antidepressant Medication

Wichers

Barge-Schaapveld

Nicolson

et al. 2008

Neuropsychopharmacol

126

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Depression has often been associated with increased negative affect reactivity to stress (Stress-Sensitivity) and reduced capacity to experience pleasure or positive affect (Reward Experience). To date, no studies have prospectively examined changes in StressSensitivity and Reward Experience following antidepressant treatment. The sample included 83 depressed patients and 22 healthy controls. A randomized controlled trial was carried out with patients receiving either imipramine or placebo for 6 weeks. At baseline and 6 weeks, patients and controls participated in an Experience Sampling procedure, prospectively measuring ecologically valid daily life appraisals of activities and mood states. The course of depression was assessed with the Hamilton Depression Rating Scale (HDRS). Multilevel linear regression analyses showed that patients had higher negative and lower positive appraisals of activities than controls. In addition, patients showed increased Stress-Sensitivity (negative affect reactivity to negatively appraised activities). Treatment with imipramine decreased Stress-Sensitivity and increased Reward Experience (positive affect reactivity to positively appraised activities). Changes in Stress-Sensitivity and Reward Experience were in part reducible to changes in the process of activity appraisal itself. However, increase in Reward Experience, but not decrease in Stress-Sensitivity, discriminated between patients who responded and those who did not, independent of changes in the process of activity appraisal itself. Response to treatment in depression may be conditional on restoration of hedonic capacity, the cerebral substrate of which requires further study in relation to antidepressant response. A search for (synergistic) antidepressant therapies specifically targeting ability to experience reward may be warranted.

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Section: Methods Subjectsmentioning

confidence: 99%

“…At each beep, ESM mood adjectives were assessed, conform previous study (Barge-Schaapveld and Nicolson, 2002). Factor analysis, using principal component analysis with oblique rotation, was used to generate a factor representing PA and one representing NA.…”

Section: Measurementsmentioning

confidence: 99%

Reduced Stress-Sensitivity or Increased Reward Experience: The Psychological Mechanism of Response to Antidepressant Medication

Wichers

Barge-Schaapveld

Nicolson

et al. 2008

Neuropsychopharmacol

126

View full text Add to dashboard Cite

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“…The subjects are instructed to complete the questionnaire upon hearing beeps from the wristwatches, which are preprogrammed to beep randomly a number of times a day to elicit experience samples. Over the past decade, ESMp has been used extensively to study diverse psychiatric populations including individuals with schizophrenia (Delespaul, 1995;Delespaul et al, 2002;Myin-Germeys et al, 2000, 2001, psychosis (Myin-Germeys et al, 2003a,b, 2004, psychosis-proneness (Husky et al, 2004;Tournier et al, 2003;Verdoux et al, 2003), depression and bipolar disorder (Barge-Schaapveld and Nicolson, 2002;Barge-Schaapveld et al, 1995, 1999Peeters et al, 2003;Swendsen and Compagnone, 2000;Wang et al, 2004), criminal offenders and violent psychiatric patients (Hillbrand and Waite, 1994;Hillbrand et al, 2000), as well as cannabis users Verdoux et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Computerized experience sampling method (ESMc): Assessing feasibility and validity among individuals with schizophrenia

Kimhy

Delespaul

Corcoran

et al. 2006

Journal of Psychiatric Research

134

112

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The Experience Sampling Method (ESM) is an ecologically valid, time-sampling of self-reports developed to study the dynamic process of person-environment interactions. ESM with digital wristwatch and booklets (paper-based ESM; ESMp) has been used extensively to study schizophrenia. The present study is designed to test the feasibility and validity of using Computerized ESM (ESMc) among individuals with schizophrenia. ESMc is advantageous in allowing for recording of precise time-stamps of responses. We used PDAs ("Personal Digital Assistant"; Palm handheld computers) to collect data on momentary psychotic symptoms, mood, and thoughts over a one day period among 10 hospitalized schizophrenia patients and 10 healthy controls. ESMc was equally acceptable to both groups, with similar ratings of comfort carrying the PDAs and operating them, interference with daily activities, as well as response rates. The schizophrenia patients reported significantly higher ratings of auditory and visual hallucinations, suspiciousness, sense of unreality, lack of thought control, fear of losing control, difficulty expressing thoughts, as well as depression/sadness, loneliness and less cheerfulness. Significant inverse relationships were found among both groups between ratings of feeling cheerful and being stressed, irritated, and sad/depressed. Among the schizophrenia subjects, the correlation between ratings of suspiciousness on ESMc and Scale for Assessment of Positive Symptoms (SAPS) approached significance, as well as the link between suspiciousness and stress. Our results support the feasibility and validity of using ESMc for assessment of momentary psychotic symptoms, mood, and experiences among individuals with schizophrenia. The authors discuss the potential applications of combining ESMc with ambulatory physiological measures.

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“…Only 2 TCA studies had major depressive disorder as the single diagnosis, and the weighted mean difference for that study was -1.37 (95% CI, -2.52 to -0.22). 19,29 For the SSRI studies there were 4 studies HAMD = Hamilton depression scale; 50%H = discrete outcomes where improvement is a greater than 50% reduction in HAMD; MADRS= Montgomery-Asberg Depression Rating Scale; 50%M = discrete outcomes where improvement is a greater than 50% reduction in the MADRS; heterogeneous = patients thought by their general practitioner to be depressed, which may or may not include patients with major depression as opposed to the studies with only patients with major depression; MDD = major depressive disorder; ModDD = moderate depressive disorder.* Quality high if adequate sample size, concealment, description of treatment, representative sample, specifi ed inclusion, details of withdrawals, valid outcomes. † High dose defi ned as majority of TCA treated patients receiving at least equivalent of 100 mg/d amitriptyline (60 mg mianserin).…”

mentioning

confidence: 99%

Efficacy and Tolerability of Tricyclic Antidepressants and SSRIs Compared With Placebo for Treatment of Depression in Primary Care: A Meta-Analysis

Arroll

MacGillivray²,

Ogston³

et al. 2005

The Annals of Family Medicine

300

166

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PURPOSE Depression is common in primary care. There are no systematic reviews of depression treatment comparing antidepressants with placebo; hence, we do not know whether these medications are effective in primary care. METHODSWe searched the Cochrane Collaboration Depression, Anxiety and Neurosis Group register of controlled trials, MEDLINE, International Pharmaceutical abstracts, PsycINFO, and EMBASE. Abstracts of potential studies were reviewed independently by 2 authors. Studies needed to include randomized controlled trials of either a tricyclic antidepressant (TCA) or selective serotonin reuptake inhibitor (SSRI), or both, and placebo in a primary care setting. The data and quality of the studies were extracted and assessed by 2 authors blind to the other's choice. Disagreements were resolved by discussion. The main outcome measures were the standardized mean difference and weighted mean difference of the fi nal mean depression scores, the relative risk of improvement, and the number withdrawing because of side effects. Pooling of results was done using Review Manager 4.2.2.RESULTS There were 10 studies in which TCAs were compared with placebo, 3 in which SSRIs were compared with placebo, and 2 with both compared with placebo. One half of the studies were of low methodological quality, and nearly all studies were of short duration, typically 6 to 8 weeks. Pooled estimates of effi cacy data showed a relative risk of 1.26 (95% CI, 1.12-1.42) for improvement with TCAs compared with placebo; For SSRIs, relative risk was 1.37 (95% CI, 1.21-1.55). Most patients, 56% to 60%, responded well to active treatment compared with 42% to 47% for placebo. The number needed to treat for TCAs was about 4, and for SSRIs it was 6. The numbers needed to harm (for withdrawal caused by side effects) ranged from 5 to 11 for TCAs and 21 to 94 for SSRIs. Low-dose (100 mg or 75 mg) as well as high-dose TCAs were effective.CONCLUSION This systematic review is the fi rst comparing antidepressants with placebo for treatment of depression in primary care. Both TCAs and SSRIs are effective. This review is also the fi rst to show that low-dose TCAs are effective in primary care. Prescribing antidepressants in primary care is a more effective clinical activity than prescribing placebo. Doubts about the effectiveness of antidepressant medication and other therapies, such as cognitive therapy, may contribute to the variability in primary care management of depression.3,4 Up to 40% of depressed patients fail to show a response to fi rst-line antidepressant drug treatment, 5 and of those that do respond, only a proportion will achieve full recovery.6 One cohort study of primary care patients found that 60% of depressed patients treated with medication and 50% with milder depression still met the criteria for caseness at 1 year. 7Recent reports have indicated an urgent need to review the evidence of only those studies of antidepressant effi cacy on patient samples based in primary care. 8,9 Several completed reviews and protocols are c...

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Effects of Antidepressant Treatment on the Quality of Daily Life

Cited by 82 publications

References 33 publications

Reduced Stress-Sensitivity or Increased Reward Experience: The Psychological Mechanism of Response to Antidepressant Medication

Reduced Stress-Sensitivity or Increased Reward Experience: The Psychological Mechanism of Response to Antidepressant Medication

Computerized experience sampling method (ESMc): Assessing feasibility and validity among individuals with schizophrenia

Efficacy and Tolerability of Tricyclic Antidepressants and SSRIs Compared With Placebo for Treatment of Depression in Primary Care: A Meta-Analysis

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