Effects of antiepileptic drug on thyroid hormones in patients with epilepsy: A meta-analysis

Zhang, Yinxi; Shen, Chun‐Hong; Lai, Qi‐Lun; Fang, Gao‐Li; Ming, Wenjie; Lu, Ru-Yi; Ding, Meiping

doi:10.1016/j.seizure.2016.01.010

Cited by 41 publications

(36 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Also, the results showed that patients receiving carbamazepine had the lowest T3, T4, and FT4 levels than patients receiving other AEDs. These results agree with the results reported by Zhang et al 10 and Abobker et al 12 Two possible explanations for this result include carbamazepine-accelerated metabolism of thyroid hormones through induction of the hepatic P 450 enzyme system, and interference with thyroid hormone competitive binding to thyroid-binding globulin. 9 Our results partly agree with those of Elmasry et al 17 who conducted a study on 30 children with epilepsy and 15 healthy control children and reported lower FT4 level in epileptic patients, while no significant difference was found in TSH levels between patients and controls.…”

Section: Discussionsupporting

confidence: 93%

“…In studying the effect of Na valproate on thyroid function, we found lower serum levels of T3, T4, and higher TSH levels in patients with epilepsy in comparison with the control group and no significant difference in FT4 between the two groups. These results agreed with both Zhang et al 10 and Yılmaz et al 11 who showed the same results. Also, Abobker et al 12 studied thyroid dysfunction in children with epilepsy and its association with AEDs in Sudanese children.…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Is It Necessary to Measure Thyroid Hormone Levels in Children Receiving Antiepileptic Drugs?

Aziz

Elela

2018

J Pediatr Epilepsy

View full text Add to dashboard Cite

Purpose This article evaluates the effect of antiepileptic drugs (AEDs) on thyroid function tests in children with epilepsy. Methodology One hundred twenty children were studied, with 40 patients taking older generation AEDs Na valproate (N = 20) and carbamazepine (N = 20), 40 patients taking newer generation AEDs levetiracetam (N = 20) and oxcarbazepine (N = 20), and 40 healthy children as controls. Serum T3, T4, FT4, and thyroid-stimulating hormone (TSH) were measured. Results Patients taking Na valproate had lower T3, T4, and a higher TSH level than controls. Patients taking carbamazepine had the lowest T3, T4, and FT4 serum levels among patients receiving AEDs. Conclusion The thyroid function tests were affected by the use of Na valproate and carbamazepine compared to both the control group and the group taking newer AEDs oxcarbazepine and levetiracetam. In addition, there was no effect of levetiracetam on thyroid function test results.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Is It Necessary to Measure Thyroid Hormone Levels in Children Receiving Antiepileptic Drugs?

Aziz

Elela

2018

J Pediatr Epilepsy

View full text Add to dashboard Cite

show abstract

“…The only correlation observed between AED blood levels and thyroid hormone levels was a significant negative correlation between the CBZ blood level and fT4 level (p=0.016). In the literature, findings regarding the effect of VPA on thyroid function are inconsistent; some studies reported an association between VPA and increased thyroid hormone levels, whereas others reported lowered levels or no effect at all (15)(16)(17)(18). The effect of VPA on serum thyroid hormone levels could not be fully explained.…”

Section: Discussionmentioning

confidence: 98%

“…The effect of VPA on serum thyroid hormone levels could not be fully explained. Studies on the effect of VPA on the thyroid hormones showed different results, an association between VPA and decreased and increased hormones levels has been reported by different studies (15)(16)(17)(18). It has been reported that VPA may affect thyroid hormone levels due to its enzymatic inhibitory effect rather than the induction of microsomal enzymes in the liver (16).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Antiepileptic Drug Treatment on Thyroid Hormone Levels in Epilepsy Patients

Mutlu¹

2019

Haseki

View full text Add to dashboard Cite

Aim: Antiepileptic drugs (AEDs) can have an effect on hormone metabolism and function, and alter serum levels of some hormones. This study aimed to determine the effects of AEDs on thyroid function test results in epilepsy patients. Methods:The study included 82 epilepsy patients aged 18-45 years. Serum free thyroxin (fT4), free triiodothyronine (fT3), and thyroidstimulating hormone (TSH) levels were measured in all the participants. Thyroid hormone levels in subgroups were investigated. In addition, Serum AED and thyroid hormone levels and duration of AED use and thyroid hormone levels were analyzed. Results:Although there were differences in thyroid hormone levels among patient subgroups, the differences did not reach statistical significance. There was no significant correlation between the duration of AED use and thyroid function parameters in the monotherapy subgroup. The only correlation observed between serum AED levels and thyroid function test results was that decreased serum fT4 level was associated with decreased carbamazepine level in blood. Conclusion:In this study, we found a significant decrease in fT4 level with only increased serum carbamazepine level. Different results in our study and similar studies in the literature showed that there could be many different physiological and environmental factors affecting thyroid hormone levels.Amaç: Antiepileptik ilaçlar (AEİ) hormon metabolizması ve fonksiyonu üzerinde etkili olabilir ve kan seviyelerini değiştirebilirler. Bu çalışmada, epilepsi hastalarında AEİ'nin tiroid hormon düzeyleri üzerine etkisinin araştırılması planlandı.Yöntemler: Çalışmamıza yaşları 18-45 arasında olan 83 hasta alındı. Tüm hastalarda serumda Serbest Tiroksin (fT4), Serbest Triiodotironin (FT3) ve tiroid stimüle edici hormon (TSH) düzeyleri ölçüldü. Altgruplar arasında tiroid hormon düzeyleri karşılaştırıldı. Ayrıca, AEİ kan düzeyleri ile tiroid hormon düzeyleri ve AEİ kullanım süreleri ile tiroid hormon düzeyleri arasında bağlantı olup olmadığı incelendi.Bulgular: Hasta alt grupları arasında tiroid hormon düzeyleri arasında farklılıklar olsa da istatiksel olarak anlamlı sonuç bulunmadı. AEİ kullanımı süresi ile tiroid hormon düzeyleri arasında da istatiksel olarak anlamlı ilişki saptanmadı. Sadece, AEİ kan düzeyleri ile tiroid fonksiyon testleri arasında sadece karbamazapin (CBZ) kan düzeyinin artışı ile fT4 düzeyinin azalmasının istatiksel olarak anlamlı olduğu saptandı.Sonuç: Bu çalışmada sadece CBZ serum düzeylerinin artmasına bağlı fT4 hormon düzeylerinin anlamlı derecede azaldığını saptadık. Çalışmamızda ve literatürdeki benzer çalışmalarda farklı sonuçların bulunması, tiroid hormon düzeylerini etkileyen bir çok farklı fizyolojik ve çevresel faktörlerin olabileceğini göstermiştir.

show abstract

Side effects of long-term oral anti-seizure drugs on thyroid hormones in patients with epilepsy: a systematic review and network meta-analysis

et al. 2022

View full text Add to dashboard Cite

Effects of antiepileptic drug on thyroid hormones in patients with epilepsy: A meta-analysis

Abstract: Our study suggests that use of AEDs such as CBZ, PHT, and VPA, was associated with alteration of thyroid hormones among patients with epilepsy.

Cited by 41 publications

References 59 publications

Is It Necessary to Measure Thyroid Hormone Levels in Children Receiving Antiepileptic Drugs?

Is It Necessary to Measure Thyroid Hormone Levels in Children Receiving Antiepileptic Drugs?

Effect of Antiepileptic Drug Treatment on Thyroid Hormone Levels in Epilepsy Patients

Side effects of long-term oral anti-seizure drugs on thyroid hormones in patients with epilepsy: a systematic review and network meta-analysis

Contact Info

Product

Resources

About