Effects of antihypertensive agents on circadian blood pressure in hypertensive patients with previous brain infarction

Abstract

To evaluate the effects of antihypertensive agents on Captopril (12.5 mg) twice daily (n = 15) produced a mild reduction in BP with little change in the circadian patthe circadian blood pressure (BP) of patients with previous brain infarction, the ambulatory BP was measured tern. The slow-release nifedipine group had the greatest decrease in mean systolic and diastolic BP. The heart non-invasively for 24 h before and after administration of antihypertensive agents. One hundred milligrams of rate significantly increased after administration of slowrelease nifedipine and decreased after administration of acebutolol twice daily (n = 15) is effective in lowering the BP during the daytime, but has little effect during acebutolol. To reduce stroke recurrence, we should consider the effects of antihypertensive agents on circadian the night and the morning. Twenty milligrams of slowrelease nifedipine twice daily (n = 14) produced a con-BP in hypertensive patients with previous brain infarction. sistent reduction in the BP over the entire 24-h period and effectively blunted the rise in BP in the morning.

Why β-blockers are not cardioprotective in elderly patients with hypertension

“…It is known that nondippers are at a higher cardiovascular risk than dippers [19,20]. β-blockers have no effect on the diurnal blood pressure variation [21][22][23], whereas calcium antagonists and diuretics may convert nondippers into dippers and thereby decrease the cardiovascular risk [24,25]. Elderly hypertensive patients have very often isolated systolic hypertension with a wide pulse pressure.…”