Effects of Antihypertensive Drugs and Exercise Training on Insulin Sensitivity in Spontaneously Hypertensive Rats

Guo, Qi; Minami, Naoyoshi; Mori, Nobuyoshi; Nagasaka, Makoto; Itoh, Osamu; Kurosawa, Hájíme; Kanazawa, Masayuki; Kohzuki, Masahiro

doi:10.1291/hypres.31.525

Cited by 14 publications

(10 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…22, 23 Briefly, before the start of the glucose clamp, fasting blood glucose was measured by a blood glucose test meter (A790820; GUNZE, Kyoto, Japan). An initial bolus of insulin (25 mU kg −1 of Humalin R, U-100; Eli Lilly Japan, Kobe, Japan) was infused through a venous catheter, and this step was followed by a constant infusion of insulin at a rate of 4 mU kg −1 min for 147 min.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Losartan modulates muscular capillary density and reverses thiazide diuretic-exacerbated insulin resistance in fructose-fed rats

Guo

Mori

et al. 2011

Hypertens Res

Self Cite

View full text Add to dashboard Cite

The renin–angiotensin system (RAS) is involved in the pathogenesis of insulin sensitivity (IS). The role of RAS in insulin resistance and muscular circulation has yet to be elucidated. Therefore, this study sought to determine the mechanisms of angiotensin II receptor blockers (ARBs) and/or diuretics on IS and capillary density (CD) in fructose-fed rats (FFRs). Sprague-Dawley rats were fed either normal chow (control group) or fructose-rich chow for 8 weeks. For the last 4 weeks, FFRs were allocated to four groups: an FFR group and groups treated with the thiazide diuretic hydrochlorothiazide (HCTZ), with the ARB losartan, or both. IS was evaluated by the euglycemic hyperinsulinemic glucose clamp technique at week 8. In addition, CD in the extensor digitorum longus muscle was evaluated. Blood pressure was significantly higher in the FFRs than in the controls. HCTZ, losartan and their combination significantly lowered blood pressure. IS was significantly lower in the FFR group than in the controls and was even lower in the HCTZ group. Losartan alone or combined with HCTZ significantly increased IS. In all cases, IS was associated with muscular CD, but not with plasma adiponectin or lipids. These results indicate that losartan reverses HCTZ-exacerbated insulin resistance, which can be mediated through the modulation of muscular circulation in rats with impaired glucose metabolism.

show abstract

Section: Methodsmentioning

confidence: 99%

“…The average rate of glucose infusion (mg kg −1 min −1 ) for the last 35 min was taken as an index of IS (M value). 22, 23 …”

Section: Methodsmentioning

confidence: 99%

Losartan modulates muscular capillary density and reverses thiazide diuretic-exacerbated insulin resistance in fructose-fed rats

Guo

Mori

et al. 2011

Hypertens Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…Ten microliters of arterial blood were sampled through an arterial catheter at 7-min intervals for determination of the blood glucose. The average of the rate of glucose infusion (mg/kg per min) for the last 35 min was taken as an index of insulin sensitivity (M value) [13].…”

Section: Euglycemic Hyperinsulinemic Glucose Clamp Techniquementioning

confidence: 99%

Methylglyoxal contributes to the development of insulin resistance and salt sensitivity in Sprague–Dawley rats

Guo

Mori

Jiang

et al. 2009

Journal of Hypertension

Self Cite

View full text Add to dashboard Cite

show abstract

“…Although no alteration in the composition of types of fiber was observed in the trained SHR and SHR treated with perindopril groups when compared with the sedentary SHR group, the authors observed higher capillarization in these groups, which may be attributed to improvement in the exercise capacity. A more recently study from the same group showed that pharmacological treatment with a calcium channel blocker (azelnidipine), or an antagonizer of type I angiotensin receptor (olmesartan) or even the ET significantly increased capillary density and percentage of type I fibers in the soleus muscle of SHR 32 . Although the results in the literature are still controversial concerning the alterations in proportion of the types of fiber in response to ET, it was not possible either to observe the comparison between the profile of the types of fiber in the trained SHR group compared with its normotensive control WKY, with the aim to check normalization with the fiber type composition.…”

Section: Discussionmentioning

confidence: 98%

O treinamento físico aeróbio corrige a rarefação capilar e as alterações nas proporções dos tipos de fibra muscular esquelética em ratos espontaneamente hipertensos

Fernandes

Roque

Magalhães

et al. 2012

Rev Bras Med Esporte

View full text Add to dashboard Cite

Aerobic exercise training (ET) has been established as an important non-pharmacological treatment of hypertension, since it decreases blood pressure. Studies show that the skeletal muscle abnormalities in hypertension are directly associated with capillary rarefaction, higher percentage of fast-twitch fibers (type II) with glycolytic metabolism predominance and increased muscular fatigue. However, little is known about these parameters in hypertension induced by ET. We hypothesized that ET corrects capillary rarefaction, potentially contributing to the restoration of the proportion of muscle fiber types and metabolic proprieties. Twelve-week old Spontaneously Hypertensive Rats (SHR, n=14) and Wistar Kyoto rats (WKY, n=14) were randomly assigned into 4 groups: SHR, trained SHR (SHR-T), WKY and trained WKY (WKY-T). As expected, ten weeks of ET was effective in reducing blood pressure in SHR-T group. In addition, we analyzed the main markers of ET. Resting bradycardia, increase of exercise tolerance, peak oxygen uptake and citrate synthase enzyme activity in trained groups (WKY-T and SHR-T) showed that the aerobic condition was achieved. ET also corrected the skeletal muscle capillary rarefaction in SHR-T. In parallel, we observed reduction in percentage of type IIA and IIX fibers and simultaneous augmented percentage of type I fibers induced by ET in hypertension. These data suggest that ET prevented changes in soleus fiber type composition in SHR, since angiogenesis and oxidative enzyme activity increased are important adaptations of ET, acting in the maintenance of muscle oxidative metabolism and fiber profile.

show abstract

Effects of Antihypertensive Drugs and Exercise Training on Insulin Sensitivity in Spontaneously Hypertensive Rats

Cited by 14 publications

References 47 publications

Losartan modulates muscular capillary density and reverses thiazide diuretic-exacerbated insulin resistance in fructose-fed rats

Losartan modulates muscular capillary density and reverses thiazide diuretic-exacerbated insulin resistance in fructose-fed rats

Methylglyoxal contributes to the development of insulin resistance and salt sensitivity in Sprague–Dawley rats

O treinamento físico aeróbio corrige a rarefação capilar e as alterações nas proporções dos tipos de fibra muscular esquelética em ratos espontaneamente hipertensos

Contact Info

Product

Resources

About