Effects of Antimitotic and Anti-Inflammatory Agents on Sodium Urate-Induced Paw Swelling in Mice

Abstract

The response of sodium urate-induced paw welling in mice to various antimitotic and anti-inflammatory agents was studied. Antimitotics colchicine, vinblastine, vincristine and podophyllotoxin produced a significant suppression of paw swelling at similar dose levels. Desacetamidocolchicine, a more potent antimitotic agent than colchicine, was less active against paw swelling even when given in a 58-fold greater dose than colchicine. Anti-inflammatory agents prednisone and indomethacin inhibited paw swelling but phenylbutazone, even at lethal doses, was inactive in this respect.