Effects of antral distension on pancreatic exocrine secretion dogs: Evidence for a short reflex.

Abstract

In WHITE et al. (1960) found that distension of the gastric corpus in conscious dogs caused an increase in pancreatic secretion via the vago-vagal reflex. DEGAS and YAMAGISHI (1978) reported that distension of the pyloric antrum in conscious dogs caused an increase in pancreatic secretion mainly through the vago-vagal reflex and partly through a rise in the serum gastrin concentration. DEGAS and YAMAGISHI (1978) stated that acid distension of the pyloric antrum caused no rise in pancreatic secretion after truncal vagotomy.The gastropancreatic reflexes have not been reported in anesthetized dogs or decerebrated dogs. Most anesthetics markedly diminish both the nervous activity and pancreatic response to a given stimulus. However, BABKIN (1924) has stated that chloralose is a very suitable narcotic for the study of the pancreatic secretion.

Assessment of exocrine pancreatic function in children and adolescents with direct and indirect testing

“…Distention at the gastric antrum elicits pancreatic enzyme secretion by activation of a vago-vagal reflex called the antro-pancreatic reflex ( 26 ). The antro-pancreatic reflex is an important component of the gastric phase of pancreatic secretion ( 27 ).…”

Regulation of Pancreatic Secretion

“…Antral distension in dogs also increased pancreatic secretion by long route vagal pathways (53). An antropancreatic short reflex pathway which is blocked by hexamethonium and atropine also mediates this phase (82). In addition, atropine and vagotomy block the gastric phase providing further evidence that gastric contributions to pancreatic secretion are mediated by vagovagal cholinergic reflexes that originate in the stomach and terminate in the pancreas (173,338,339).…”