Effects of Anxiety Sensitivity and Hearing Loss on Tinnitus Symptom Severity

Abstract

ObjectiveThe aim of the present study was to examine the relative role of anxiety sensitivity and hearing loss on the tinnitus symptoms severity in a large clinical sample of patients with tinnitus.MethodsA total of 1,705 patients with tinnitus who visited the tinnitus clinic underwent the pure-tone audiometric testing and a battery of self-report questionnaires. Multiple linear regression analyses were performed to identify the relationship of anxiety sensitivity and hearing loss to tinnitus symptoms severity.ResultsBoth anxiety sensitivity and hearing loss were a significant association with of annoyance (anxiety sensitivity β=0.11, p=0.010; hearing loss β=0.09, p=0.005) and THI score (anxiety sensitivity β=0.21, p<0.001; hearing loss β=0.10, p<0.001) after adjusting for confounding factors. Meanwhile, the awareness time (β=0.19, p<0.001) and loudness (β=0.11, p<0.001) of tinnitus was associated with only the hearing loss but not with anxiety sensitivity.ConclusionOur results indicate that both hearing loss and anxiety sensitivity were associated with increased tinnitus symptom severity. Furthermore, these associations could be different according to the characteristics of tinnitus symptoms.

Clinical and Genome-wide Analysis of Cisplatin-induced Tinnitus Implicates Novel Ototoxic Mechanisms

“…Self-reported tinnitus, hearing loss, and neuropathy in cancer survivors have been linked to the Impact of Events Scale-Revised (IES-R) hyperarousal scores (14), suggesting that differences in perception and appraisal could partially explain our findings. One study showed that audiometric thresholds correlated with tinnitus awareness time and loudness, but that tinnitus-induced annoyance was associated with proneness to exhibit anxious responses (48,49). These investigations highlight how both cochlear and central nervous mechanisms contribute to tinnitus.…”

“…Cell viability of HEI-OC1 cells transfected with either pOTOS (closed circles) or the control plasmid (pControl; open circles) following treatment with increasing concentrations of cisplatin for 48 hours (P ¼ 0.004; B) or 72 hours (P ¼ 0.008; C). Inset, Human OTOS mRNA expression in HEI-OC1 cells corresponding to 0, 24, 48, and 72 hours after cisplatin treatment(24,48, 72, and 96 hours after transfection) depicted as pOTOS relative to pControl. Cell viability of L929 fibroblasts transfected with either pOTOS (closed circles) or the control plasmid (pControl; open circles) following treatment with increasing concentrations of cisplatin for 48 hours (P ¼ 0.006; D) or 72 hours (P ¼ 0.03; E).…”

“…Cell viability of L929 fibroblasts transfected with either pOTOS (closed circles) or the control plasmid (pControl; open circles) following treatment with increasing concentrations of cisplatin for 48 hours (P ¼ 0.006; D) or 72 hours (P ¼ 0.03; E). Inset, Human OTOS mRNA expression in L929 fibroblasts corresponding to 0, 24, 48, and 72 hours after cisplatin treatment(24,48, 72, and 96 hours after transfection) depicted as pOTOS relative to pControl. Data shown are from three independent experiments, with each concentration or time point within an experiment evaluated in duplicate or triplicate.…”

Anxiety-like behavior induced by salicylate depends on age and can be prevented by a single dose of 5-MeO-DMT

“…Subjective tinnitus is primarily associated with sensorineural hearing loss (Cima et al, 2019;Moon et al, 2018;Norena and Eggermont, 2003;Weisz et al, 2006) which may be the consequence of https://doi.org/10.1016/j.expneurol.2020.113175 Received 10 October 2019; Received in revised form 23 December 2019; Accepted 6 January 2020 noise trauma, ototoxic drugs, or aging. Here, we used acute salicylate injection as a tinnitus model (Rüttiger et al, 2003).…”

Analysis of influential factors of self-reported hearing loss deviation in young adults

“…Previous researches have also shown associations between occupation, stress, anxiety, tinnitus, hearing aid use, and self-reported hearing loss deviation. Tinnitus and aural fullness correlate with anxiety (Moon et al 2018;Levo et al 2014), a symptom of general psychological pressure which makes people vulnerable to hearing problems.…”