Effects of aortic valve diseases on pressure profiles in selected locations of the human arterial system

Abstract

Effects of aortic valve diseases on pressure profiles in selected locations of the human arterial system Wływ chorób zastawki aortalnej na przebiegi ciśnienia w wybranych miejscach układu tętniczego człowieka Abstract Aortic valve diseases such as aortic stenosis and aortic regurgitation, are the most frequent valvular heart diseases. The lesions in the valves affect circulation in the whole arterial system. We study the effects with the use of a 1-D model in which an arterial segment transmits a single mode of pulse waves. The appropriate reflection coefficient and the form of the stroke pressure are devised to simulate the function of the healthy and morbid aortic valve. The time dependence of the arterial pressure is predicted at the most important locations of the arterial tree. A remarkable result is that little variations of the reflection coefficient of the vale due to the modelled diseases cause significant changes of the pressure profiles, especially at the ascending aorta, the left brachial artery and in the anterior communicating artery.