Effects of APE1 Asp148Glu polymorphisms on OPMD malignant transformation, and on susceptibility to and overall survival of oral cancer in Taiwan

Abstract

Background The associations between malignant transformation of oral potentially malignant disorders (OPMDs), oral cancer development and prognosis, and apurinic/apyrimidinic endonuclease 1 (APE1) functional polymorphisms are unclear. Methods Patients with OPMDs, patients with oral cancer, and healthy controls from the community were recruited to determine the effects of APE1 polymorphisms on malignant transformation, overall survival, and genetic susceptibility, respectively. Results The APE1 Asp148Glu polymorphisms significantly correlated with a high hazard ratio for OPMD malignant transformation (adjusted hazard ratio [AHR] = 2.29; 95% confidence interval [CI] = 1.44‐3.74) and low overall survival in oral cancer patients (AHR = 1.71, 95% CI = 1.11‐2.56) according to follow‐up and survival analysis. However, APE1 polymorphisms did not significantly correlate with development of oral cancer in the case‐control study and logistic regression analysis. Conclusions These results indicate that APE1 Asp148Glu polymorphisms may have indirect roles in increasing the OPMD malignant transformation rate and in decreasing overall survival in oral cancer patients.

Prognostic value of transforming growth factor beta receptor 1 polymorphisms in patients with oral cancer

“…APE1 plays a crucial role in repairing damaged base pairs caused by oxidative stress. APE1 Asp148Glu polymorphisms may be correlated with decreased overall survival in oral cancer patients . As for GSTM1 , Olivieri et al have found that GSTM1 null alleles were significantly associated with advanced clinical stages, which could confer increased risk of HNSCC development.…”