Effects of Apelin-13 on Human Prostate Cancer Lines [Insan Prostat Kanseri Hucre Serilerinde Apelin-13'un Etkileri]

Tekin, Suat; Sandal, Süleyman; Çolak, Cemil

doi:10.5455/medscience.2014.03.8143

Cited by 10 publications

(4 citation statements)

References 57 publications

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“…Apelin might be involved in the regulation of tumor growth, cancer cell migration, neoangiogenesis, apoptosis suppression, and even metastasis induction. Various apelin peptides can stimulate tumor growth and proliferation of many types of cancer cells, including cholangiocarcinoma (CAA) (Hall et al, 2017 ), non-small cell lung cancer (NSCLC) (Berta et al, 2010 ), gastric cancer (Feng et al, 2016 ), prostate cancer (Tekin et al, 2014 ), ovarian cancer (Hoffmann et al, 2017 ), and oral squamous cell carcinoma (Heo et al, 2012 ). The expression changes of the apelin/APJ system in cancer are shown in Table 3 .…”

Section: Apelin In Cancermentioning

confidence: 99%

“…Apelin has a mitogenic ability also in prostate cancer. Treatment with apelin-13 resulted in increased proliferation of prostate cancer cell lines (Tekin et al, 2014 ). Additionally, the 3′UTR of the APLN mRNA was complementary to miR-224, which might act as a tumor suppressor in human prostate cancer, suggesting that apelin is a direct target of miR-244.…”

Section: Apelin In Cancermentioning

confidence: 99%

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The Role of Apelin in Cardiovascular Diseases, Obesity and Cancer

Wysocka

Pietraszek-Gremplewicz

2018

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Apelin is an endogenous peptide identified as a ligand of the G protein-coupled receptor APJ. Apelin belongs to the family of adipokines, which are bioactive mediators released by adipose tissue. Extensive tissue distribution of apelin and its receptor suggests, that it could be involved in many physiological processes including regulation of blood pressure, body fluid homeostasis, endocrine stress response, cardiac contractility, angiogenesis, and energy metabolism. Additionally, this peptide participates in pathological processes, such as heart failure, obesity, diabetes, and cancer. In this article, we review current knowledge about the role of apelin in organ and tissue pathologies. We also summarize the mechanisms by which apelin and its receptor mediate the regulation of physiological and pathological processes. Moreover, we put forward an indication of apelin as a biomarker predicting cardiac diseases and various types of cancer. A better understanding of the function of apelin and its receptor in pathologies might lead to the development of new medical compounds.

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Section: Apelin In Cancermentioning

confidence: 99%

Section: Apelin In Cancermentioning

confidence: 99%

The Role of Apelin in Cardiovascular Diseases, Obesity and Cancer

Wysocka

Pietraszek-Gremplewicz

2018

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“…The cell lines were preserved at 37°C in 5% CO 2 humidified incubator. The cytotoxicity effects of phosphazene compounds were determined against human breast cancer (MCF-7) and human prostate cancer (PC-3 and LNCaP) cell lines by using MTT ([3-(4,5-dimethylthiazol)-2-yl]-2,5-diphenyl-2H-tetrazolium bromide]) assay method [58][59][60][61].…”

Section: In Vitro Anticancer Activitymentioning

confidence: 99%

“…Each data point is reported as an average of 10 measurements. All cellular results were measured against control cells [58][59][60][61].…”

Section: In Vitro Anticancer Activitymentioning

confidence: 99%

Synthesis, structural characterization and anti-carcinogenic activity of new cyclotriphosphazenes containing dioxybiphenyl and chalcone groups

Görgülü

Koran

Özen

et al. 2015

Journal of Molecular Structure

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Synthesis of 2-(2,3,4-trimethoxyphenyl)-1-(substituted-phenyl)acrylonitriles: in vitro anticancer activity against MCF-7, PC-3 and A2780 cancer cell lines

et al. 2016

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A series of 2-(2,3,4-trimethoxyphenyl)-1-(substituted-phenyl)acrylonitrile (2-9) were designed and synthesized to develop new cancer drugs. The structures of synthesized compounds 2-9 were described by using melting point, mass (MALDI-TOF-MS), FT-IR, elemental analysis, 1 H, 13 C, 13 C-APT and 2D NMR spectroscopy. The in vitro anticancer activities of 2-9 against human breast cancer (MCF-7), human prostate cancer (PC-3) and human ovarian cancer cells (A2780) were investigated by [3-(4,5-dimethylthiazol)-2-yl]-2,5-diphenyl-2H-tetrazolium bromide] (MTT) assay method. Additionally, the LogIC 50 values of these compounds on A2780, MCF-7 and PC-3 cell lines were calculated by using inhibition % values by the GraphPad Prism 6 program on a computer. The results indicated that these compounds have high anticancer activity against MCF-7, PC-3 and A2780 cell lines (especially A2780 cell lines, p \ 0.05).

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Effects of Apelin-13 on Human Prostate Cancer Lines [Insan Prostat Kanseri Hucre Serilerinde Apelin-13'un Etkileri]

Abstract: Abstract

Cited by 10 publications

References 57 publications

The Role of Apelin in Cardiovascular Diseases, Obesity and Cancer

The Role of Apelin in Cardiovascular Diseases, Obesity and Cancer

Synthesis, structural characterization and anti-carcinogenic activity of new cyclotriphosphazenes containing dioxybiphenyl and chalcone groups

Synthesis of 2-(2,3,4-trimethoxyphenyl)-1-(substituted-phenyl)acrylonitriles: in vitro anticancer activity against MCF-7, PC-3 and A2780 cancer cell lines

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