Effects of apomorphine and clozapine on conditioned freezing and latent inhibition

Masson, Sueli; Avanzi, V.; Troncoso, Ana Cristina; Brandão, Marcus Lira

doi:10.1016/s0278-5846(03)00153-2

Cited by 7 publications

(2 citation statements)

References 53 publications

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“…Both olanzapine and clozapine have been found to increase water licking of an electrified water bottle in the Geller-Seifter conflict task (Moore et al, 1992)(Moore, Tye et al, 1992), demonstrating that these atypical antipsychotics may possess anxiolytic activity. However, there are other reports that fail to confirm this anxiolytic activity (Cao and Rodgers, 1997; Fernandez-Tome et al, 1979; Masson et al, 2003; Shadach et al, 1999). Still others even suggest an anxiogenic activity (Karl et al, 2006; Manzaneque et al, 2002).…”

Section: Introductionmentioning

confidence: 87%

Clozapine and olanzapine exhibit an intrinsic anxiolytic property in two conditioned fear paradigms: Contrast with haloperidol and chlordiazepoxide

Mead

Kapur

2008

Pharmacology Biochemistry and Behavior

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Section: Introductionmentioning

confidence: 87%

Clozapine and olanzapine exhibit an intrinsic anxiolytic property in two conditioned fear paradigms: Contrast with haloperidol and chlordiazepoxide

Mead

Kapur

2008

Pharmacology Biochemistry and Behavior

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“…DGanella et al, 2017 (5 mg/kg).ACalzavara et al, 2009 (2.5-10 mg/kg);Inoue et al, 1996b (5-10 mg/kg). BMasson et al, 2003 (1-5 mg/kg).CBabaei et al, 2011 (infusion, mPFC);Ishida-Tokuda et al, 1996 (10 mg/kg). DKawano et al, 2016 (4.7 mg/kg);Inoue et al, 1996b (0.25-10 mg/kg).AInoue et al, 1996b (3-30 mg/kg).…”

mentioning

confidence: 99%

50 Years of Research on Dopamine’s Role in Passive Aversive Conditioning and Extinction: A Systematic Review

Hamati

Ahrens

Holahan

et al. 2023

Preprint

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Dopamine, a catecholamine neurotransmitter, has historically been associated with the encoding of reward, whereas its role in aversion has received less attention. Here, we systematically gather the vast evidence for a role of dopamine in the simplest form of aversive learning: passive aversive conditioning and extinction. In the past, crude methods were used to augment or inhibit dopamine in order to study its relationship with fear conditioning and extinction. More advanced techniques such as conditional genetic, chemogenic, and optogenetic approaches now provide causal evidence for dopamine’s role in these learning processes. Dopamine neurons encode fear and extinction-related information and convey the signal via activation of D1, D2, D3, and D4 receptor sites particularly in the amygdala, prefrontal cortex, and striatum in order to continuously form, consolidate, retrieve, and update fear and extinction memory in a dynamic and reciprocal manner. Based on the reviewed literature, we conclude that dopamine is crucial for the encoding of passive aversive conditioning and contributes in a way that is comparable to its role in encoding reward.

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Using the pharmacology of latent inhibition to model domains of pathology in schizophrenia and their treatment

Weiner

Arad

2009

Behavioural Brain Research

111

114

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Effects of apomorphine and clozapine on conditioned freezing and latent inhibition

Cited by 7 publications

References 53 publications

Clozapine and olanzapine exhibit an intrinsic anxiolytic property in two conditioned fear paradigms: Contrast with haloperidol and chlordiazepoxide

Clozapine and olanzapine exhibit an intrinsic anxiolytic property in two conditioned fear paradigms: Contrast with haloperidol and chlordiazepoxide

50 Years of Research on Dopamine’s Role in Passive Aversive Conditioning and Extinction: A Systematic Review

Using the pharmacology of latent inhibition to model domains of pathology in schizophrenia and their treatment

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