Effects of Apomorphine in Mice of Different Strains

Lapin, I. P.

doi:10.1007/978-1-4615-7697-6_3

Cited by 7 publications

(2 citation statements)

References 11 publications

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“…Locomotions and rearings in response to ethanol [3], antidepressants and cholinolytics [4], and apomorphine [5] were also compared in male BALB/c, C57B1/6, CC57BR, and C3H/A mice.…”

Section: Methodsmentioning

confidence: 99%

“…

Key Words: vertical activity; horizontal activity; mice; inhibitory action of drugsExperiments on mice and rats using different classes of psychotropic drugs [4][5][6] have repeatedly demonstrated that the vertical component of orienting motor activity (rearings) is more susceptible to the inhibitory action of these drugs than the horizontal component (locomotion). To date, however, no special quantitative comparisons of these components have been reported.

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Vertical motor activity is inhibited in mice by lower doses of psychotropic drugs than horizontal activity

1995

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This study of 19 psychotropic drugs for their effect on motor activity of mice showed that all types of drugs (tranquilizers, sedatives, neuroleptics, antidepressants, and anticonvulsants) inhibit vertical activity to a greater extent than horizontal activity. Key Words: vertical activity; horizontal activity; mice; inhibitory action of drugsExperiments on mice and rats using different classes of psychotropic drugs [4][5][6] have repeatedly demonstrated that the vertical component of orienting motor activity (rearings) is more susceptible to the inhibitory action of these drugs than the horizontal component (locomotion). To date, however, no special quantitative comparisons of these components have been reported. We therefore decided to summarize and process the data of our own experiments where rearings and locomotion were measured concurrently and a dose-effect curve was plotted. We were especially interested in finding out whether drugs of different classes have differential inhibitory effects on rearings and locomotion. MATERIALS AND METHODS Male SHR mice (body weight 18-22 g) from theRappolovo nursery were used in the experiment. chamber only once. Before the measurements the mice were kept in 20xl0xl0 cm metal cases, 8 to 10 animals in each. In some test series, in order that the size of the group from which a mouse was taken to the actometer be kept constant, an intact mice was placed in the box to replace the one removed. This procedure, which did not significantly influence the effects of the drugs under study, was necessary because it had been noticed that the locomotion and rearings of a control mouse (one injected with physiological saline instead of a drug) taken to the actometer from a larger group (5-10 animals) were at significantly lower levels than those of a mouse taken from a smaller group (1-5 animals). The tests were run in the daytime (between 10 am and 4 pm) at room temperature under constant artificial illumination (100-140 luxes).Drugs were injected intraperitoneally in a volume equal to 1% of body weight 30 min before the test. Ethanol was administered via a stomach tube 15 min before the test. EDs0 values for inhibition of locomotion (LEDs0) and rearings (REDs0) were calculated by the Wilcoxon and Litchfield method [1]. The significance of differences between LEDs0 and REDs0 was determined for each drug (but not between drugs) using Mebistat-F software. RESULTSThe REDs0 values of all drugs were significantly lower than their LEDs0, with the exception of halo-0007-4888/95/0010-I019512.50 9Plenum Publishing Corporation

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“…Locomotions and rearings in response to ethanol [3], antidepressants and cholinolytics [4], and apomorphine [5] were also compared in male BALB/c, C57B1/6, CC57BR, and C3H/A mice.…”

Section: Methodsmentioning

confidence: 99%

“…

…”

mentioning

confidence: 99%

Vertical motor activity is inhibited in mice by lower doses of psychotropic drugs than horizontal activity

1995

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Clonidine-induced aggression in mice: Role of genotype and domapminergic system

Nikulina¹,

Klimek²,

Popova³

1989

Bull Exp Biol Med

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Verticalization of behavior elicited by dopaminergic mobilization is qualitatively different between C57BL/6J and DBA/2J mice

Tirelli

Witkin

1994

Psychopharmacology

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Behavioral effects of dopaminergic stimulation were evaluated in C57BL/6J mice and compared to the effects occurring in DBA/2J mice, an inbred strain with reduced densities of striatal dopamine receptors. Effects of apomorphine (0.5-64 mg/kg) alone and in combination with cocaine (30 mg/kg) were assessed using a time-sampling technique that classified climbing and leaning in separate categories. Locomotion was also assessed in a separate experiment. Climbing occurred in DBA/2J mice only at doses of apomorphine that were 16 times higher than the smallest effective dose in C57BL/6J mice; nevertheless, relative to baseline values, effects were fairly comparable. By contrast, whereas DBA/2J mice showed dose-dependent leaning under apomorphine, C57BL/6J mice exhibited little leaning even at doses not producing climbing, and only after the highest apomorphine dose was leaning significantly increased. Apomorphine was equipotent in inducing gnawing across strains, although somewhat less efficacious in DBA/2J mice. When given alone, cocaine produced significant climbing, but not leaning or gnawing, in either strain. Whereas cocaine potentiated apomorphine-induced climbing and gnawing in both strains, apomorphine-induced leaning was not consistently changed by cocaine in either strain. These effects were not indirectly due to hyperkinesia, since neither apomorphine alone nor apomorphine and cocaine in combination was stimulant; apomorphine alone reduced locomotor activity and attenuated cocaine-induced hyperkinesia. The present data do not support a unitary, purely quantitative, account of insensitivity to dopaminergic stimulation based upon low densities of striatal dopamine receptors in DBA/2J mice. Rather, this constellation of results is suggestive of qualitative interstrain dissimilarities in dopaminergic responsiveness that could reflect organizational differences in receptor populations.

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Effects of Apomorphine in Mice of Different Strains

Cited by 7 publications

References 11 publications

Vertical motor activity is inhibited in mice by lower doses of psychotropic drugs than horizontal activity

Vertical motor activity is inhibited in mice by lower doses of psychotropic drugs than horizontal activity

Clonidine-induced aggression in mice: Role of genotype and domapminergic system

Verticalization of behavior elicited by dopaminergic mobilization is qualitatively different between C57BL/6J and DBA/2J mice

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