Effects of Appetitive and Aversive Motivational States on Wanting and Liking of Interpersonal Touch

Massaccesi, Claudia; Korb, Sebastian; Skoluda, Nadine; Nater, Urs M.; Silani, Giorgia

doi:10.1016/j.neuroscience.2020.09.025

Cited by 13 publications

(29 citation statements)

References 65 publications

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“…Kumar et al, 2014;Lewis et al, 2014;Pool et al, 2015), stress increases wanting of rewards of social nature, such as interpersonal touch (Massaccesi et al, 2021). Differently from the present findings, in Massaccesi et al (2021) the effect of enhanced wanting for the social reward was independent from reward magnitude. In other words, participants under stress expressed higher wanting ratings for all types of social touch compared to non-stressed individuals, regardless of reward magnitude.…”

Section: Morphine-induced Increased Negative Reaction To Stress Is Associated With Enhanced Social Motivationcontrasting

confidence: 95%

“…This pattern of results is consistent with previous findings from our group indicating that, as already shown for other kinds of reward like food and money (e.g. Kumar et al, 2014;Lewis et al, 2014;Pool et al, 2015), stress increases wanting of rewards of social nature, such as interpersonal touch (Massaccesi et al, 2021). Differently from the present findings, in Massaccesi et al (2021) the effect of enhanced wanting for the social reward was independent from reward magnitude.…”

Section: Morphine-induced Increased Negative Reaction To Stress Is Associated With Enhanced Social Motivationsupporting

confidence: 93%

“…During reward anticipation (announcement of the best attainable reward), the increased subjective wanting of social touch in the morphine group was accompanied by greater activity of the corrugator muscle. Previous research indicates that individuals relax the corrugator during anticipation and consumption of rewarding stimuli, showing an inverse relationship between corrugator activity and reward wanting/liking (Korb, Götzendorfer, et al, 2020;Massaccesi et al, 2021;Mayo et al, 2018;Ree et al, 2020;Sato et al, 2020). Here, in contrast, we observed greater frowning for most wanted stimuli.…”

Section: Morphine-induced Increased Negative Reaction To Stress Is Associated With Enhanced Social Motivationcontrasting

confidence: 64%

“…This would align well with the observation that participants administered with morphine also exerted more effort in order to obtain the high reward, as compared to the low reward, and that this difference in force exerted was greater than in the placebo group (but with FDR p = 0.068 did not reach the statistical significance). Alternatively, a reason for the partially different result pattern might be that, differently from the current study, in Massaccesi et al (2021) participants were allowed to individually rank the three types of touch as high, low and very low.…”

Section: Morphine-induced Increased Negative Reaction To Stress Is Associated With Enhanced Social Motivationmentioning

confidence: 68%

“…Based on previous work that had investigated the effects of stress on social reward processing (Massaccesi et al, 2021) and the effects of similar compounds on stress responses (Bershad et al, 2018), we aimed at collecting data from 40 participants per group. The study sample included 82 participants, of which 42 received morphine (MORPH) and 40 received a placebo (PLB).…”

Section: Participantsmentioning

confidence: 99%

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Opioid-blunted cortisol response to stress is associated to increased negative mood and wanting of social reward

Massaccesi

Willeit

Quednow

et al. 2021

Preprint

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Animal research suggests a central role of the mu-opioid receptor (MOR) system in mediating contact seeking and the stress-buffering function of social touch. However, the human neurochemistry of social motivation in aversive situations is still poorly understood. In a randomized, double-blind, between-subject design, healthy female volunteers (N = 80) received either 10 mg of the mu-opioid agonist morphine sulfate or a placebo. Following psychosocial stress induction, participants engaged in a social reward task, in which the motivation (subjective ratings of wanting and physical effort) to obtain skin-to-skin social touch and the hedonic reactions (subjective ratings of liking and facial electromyography) elicited by it were assessed. Morphine administration prevented the increase of salivary cortisol, usually observed in response to acute stress exposure. The dampened physiological reaction to the psychosocial stress was associated with increased negative mood and subsequent higher subjective wanting of the most pleasurable touch. Furthermore, participants administered with morphine displayed greater activity of the corrugator muscle during reward anticipation, possibly tracking enhanced attention toward the social stimuli. Overall, the results provide novel evidence on the effect of exogenous opioids administration on the reactions to psychosocial stress and point to a state-dependent regulation of social motivation.

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Section: Morphine-induced Increased Negative Reaction To Stress Is Associated With Enhanced Social Motivationcontrasting

confidence: 95%

Section: Morphine-induced Increased Negative Reaction To Stress Is Associated With Enhanced Social Motivationsupporting

confidence: 93%

Section: Morphine-induced Increased Negative Reaction To Stress Is Associated With Enhanced Social Motivationcontrasting

confidence: 64%

Section: Morphine-induced Increased Negative Reaction To Stress Is Associated With Enhanced Social Motivationmentioning

confidence: 68%

Section: Participantsmentioning

confidence: 99%

See 3 more Smart Citations

Opioid-blunted cortisol response to stress is associated to increased negative mood and wanting of social reward

Massaccesi

Willeit

Quednow

et al. 2021

Preprint

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Effects of dopamine and opioid receptor antagonism on the neural processing of social and nonsocial rewards

Massaccesi,

Korb,

Götzendorfer

et al. 2024

Human Brain Mapping

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Rewards are a broad category of stimuli inducing approach behavior to aid survival. Extensive evidence from animal research has shown that wanting (the motivation to pursue a reward) and liking (the pleasure associated with its consumption) are mostly regulated by dopaminergic and opioidergic activity in dedicated brain areas. However, less is known about the neuroanatomy of dopaminergic and opioidergic regulation of reward processing in humans, especially when considering different types of rewards (i.e., social and nonsocial). To fill this gap of knowledge, we combined dopaminergic and opioidergic antagonism (via amisulpride and naltrexone administration) with functional neuroimaging to investigate the neurochemical and neuroanatomical bases of wanting and liking of matched nonsocial (food) and social (interpersonal touch) rewards, using a randomized, between‐subject, placebo‐controlled, double‐blind design. While no drug effect was observed at the behavioral level, brain activity was modulated by the administered compounds. In particular, opioid antagonism, compared to placebo, reduced activity in the medial orbitofrontal cortex during consumption of the most valued social and nonsocial rewards. Dopamine antagonism, however, had no clear effects on brain activity in response to reward anticipation. These findings provide insights into the neurobiology of human reward processing and suggest a similar opioidergic regulation of the neural responses to social and nonsocial reward consumption.

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Positive affect: nature and brain bases of liking and wanting

Nguyen

Naffziger

Berridge

2021

Current Opinion in Behavioral Sciences

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Effects of Appetitive and Aversive Motivational States on Wanting and Liking of Interpersonal Touch

Cited by 13 publications

References 65 publications

Opioid-blunted cortisol response to stress is associated to increased negative mood and wanting of social reward

Opioid-blunted cortisol response to stress is associated to increased negative mood and wanting of social reward

Effects of dopamine and opioid receptor antagonism on the neural processing of social and nonsocial rewards

Positive affect: nature and brain bases of liking and wanting

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