1987
DOI: 10.1016/s0003-4975(10)62153-4
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Effects of Aprotinin on Hemostatic Mechanisms during Cardiopulmonary Bypass

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Cited by 327 publications
(88 citation statements)
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“…Although its exact mechanism of action has not been completely understood, it modulates coagulation factors by inhibiting plasmin and kallikrein activity [11,15]. In addition, it has been shown to stabilize platelet membrane receptors, thus improving platelet adherence and function [13].…”
Section: Introductionmentioning
confidence: 99%
“…Although its exact mechanism of action has not been completely understood, it modulates coagulation factors by inhibiting plasmin and kallikrein activity [11,15]. In addition, it has been shown to stabilize platelet membrane receptors, thus improving platelet adherence and function [13].…”
Section: Introductionmentioning
confidence: 99%
“…(23) Fibrin degradation increases during CPB, and fibrin degradation products have been implicated in impaired fibrin formation, platelet dysfunction, and endothelial disruption resulting in capillary injury. (24,25) Moreover, plasmin, a potent platelet inhibitor, reportedly degrades platelet adhesion receptors Gp Ib and Gp IIb in vitro, and by 50% in vivo during CPB, most notably at hypothermic temperatures (1) When added to washed platelets, plasmin reduces platelet membrane Gp Ib content by approximately 75%. (25) Taken together, these observations suggest that stimulation of the fibrinolytic system in CPB may result in decreased platelet function.…”
Section: Discussionmentioning
confidence: 99%
“…Future efforts will be exerted to assure more complete acceptance of our established guidelines and compliance with the principles of reducing usage of blood bank products. In addition, the use of other modalities which reduce postoperative bleeding in cardiac surgical patients, such as desmopressin and aprotinin, will be encouraged [27,28].…”
Section: Discussionmentioning
confidence: 99%