Effects of Aqueous Bryophyllum pinnatum Leaf Extract on Hematological, Renal and Sperm Indices in Wistar Rats

Aprioku, Jonah Sydney; Igbe, Ighodaro

doi:10.4172/pharmaceutical-sciences.1000258

Cited by 9 publications

(9 citation statements)

References 20 publications

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“…Administration of ethylene glycol results in calculi formation which obstructs the normal renal outflow and causes decline in glomerular filtration or obstruction of renal outflow which leads to accumulation of serum creatinine and blood urea nitrogen [ 9 , 14 , 35 ]. Decreased serum creatinine level in group V and VI corroborates with the earlier finding in which restoration of serum creatinine level after treatment with B. pinnatum plant in the form of extract or nanoparticles against various toxicities, was recorded [ 51 , 52 , 53 ]. The plant B. pinnatum constitutes the anti‐oxidant property which averts the oxidative stress caused due to lipid peroxidation thereby helping in normalising the serum creatinine and BUN level [ 9 ].…”

Section: Discussionsupporting

confidence: 89%

Nephroprotective effect of Bryophyllum pinnatum‐ mediated silver nanoparticles in ethylene glycol‐induced urolithiasis in rat

Dighade¹,

Ingole²,

Ingle

et al. 2021

IET Nanobiotechnology

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A large population is suffering from multifactorial urolithiasis worldwide with a reoccurrence rate of almost 70%-80% in males and 47%-60% in females. In the present study, the nephroprotective effect of silver nanoparticles (AgNPs) synthesised by Bryophyllum pinnatum was evaluated in ethylene glycol-induced urolithiasis in rat. B. pinnatum-mediated AgNPs which were found to be spherical and polydispersed particles with an average size of 32.65 nm determined by transmission electron microscopy analysis, and showing an absorption peak at 432 nm by the UV-Vis spectrophotometric analysis, revealing the role of hydroxyl group in the synthesis by Fourier Transformed Infrared Spectroscopy analysis, with a zeta potential value of À 15.7 mV. The crystalline nature and fcc structure was demonstrated based on X-ray diffraction analysis. Animal study was performed on 36 male Wistar rats divided into six equal groups, which demonstrated significant increase in serum total protein, albumin and globulin and significant decrease in AST, ALT, creatinine, BUN, calcium and phosphorus in group V and VI when compared with group II and IV. No crystalluria was observed in rats given B. pinnatum AgNPs. Histopathological observations in group V and VI showed mild degenerative changes and restoration or maintenance of kidney parenchyma when compared with group II and IV rats. Thus, the authors conclude with the beneficial preventive and therapeutic nephroprotective effect of B. pinnatum-mediated AgNPs against ethylene glycol-induced urolithiasis in rats.This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Section: Discussionsupporting

confidence: 89%

Nephroprotective effect of Bryophyllum pinnatum‐ mediated silver nanoparticles in ethylene glycol‐induced urolithiasis in rat

Dighade¹,

Ingole²,

Ingle

et al. 2021

IET Nanobiotechnology

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“…WBCs and its differentials (platelets, lymphocytes, granulocytes, neutrophils) are the first line of mediators of immunoprotection against invading foreign agents in the body (Aprioku, 2017). Results showed that WBCs and the differentials obtained in both the treated and control group after 28 days of oral administration were almost similar which suggested that probably AME of A. glumaceus did not cause any significant alteration to the immune system of the treated mice.…”

Section: Discussionmentioning

confidence: 90%

A safety profile of aqueous methanol aerial extract of Alysicarpus glumaceus in mice: acute and subacute administration

Khan¹,

Sani²,

Olorukooba³

et al. 2022

jcbr

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Alysicarpus glumaceus (Vahl D.C), family-leguminosae is used traditionally for a number of ailments in Nigeria, as well as in other African countries, Asia and middle east. The leaf is taken orally for thrush, sores and asthma. While root decoction is taken for coughs and its combination with leaf sap is taken for diarrhea and as an abortifacient. The aerial parts are used for the management of neuropsychiatric disorders mainly depression and currently been used by drivers in combination with tea to keep alert on long drive in northern Nigeria. The aim of this work was to determine the median lethal dose (LD50) and the effect of aqueous methanol extract (AME) of Alysicarpus glumaceus on the body weight, behavioural changes, heamatological, histopathological parameters and rate of mortality after an acute and sub-acute toxicity study of 28 days using three graded doses (500, 1000 & 1500 mg/kg) in mice via the oral route. From the results obtained LD50 was greater than 5000 mg/kg, it had no significant effect on their body weights as well as on their physical behaviour. Slight lesions were observed in kidney and liver of animals given 1500 mg/kg of AME. There was no statistical difference (p< 0.05) between the control and the treated groups for packed cell volume and platelet count. These findings suggest that the AME of Alysicarpus glumaceus is not likely to produce toxic effects and suggest that the extract is relatively safe in mice.

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“…These fatty acids have significant importance in the human diet. Oral administration of the aqueous extract of B. pinnatum has been found to have moderately low renal and testicular toxicities [16]. The extract had also been shown to prevent the formation of renal calculi in Lithiatic Rats [17].…”

Section: Resultsmentioning

confidence: 99%

Composición de ácidos grasos de extractos etéreos de Bryophyllum pinnatum Lam., Ficus exasperata Vahl., Gossypium herbaceum Linn. y Hilleria latifolia (Lam.) H. Walt

Oso

2020

Rev. Colomb. Cienc. Quím. Farm.

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Actualmente, existe un creciente interés en identificar fuentes alternativas de ácidos grasos debido a la creciente demanda actual de productos botánicos ricos en aceite en aplicaciones industriales. El objetivo principal de este trabajo fue identificar las composiciones de ácidos grasos de extractos de éter de hojas secas de Bryophyllum pinnatum Lam., Ficus exasperata Vahl., Gossypium herbaceum Linn. y Hilleria latifolia (Lam.) H. Walt. Los ácidos grasos fueron analizados por cromatografía de gases con detector de ionización de llama. Entre los extractos de éter evaluados, los mayores contenidos de ácidos grasos saturados se encontraron en H. latifolia (27,96%) con presencia principal de ácido esteárico en comparación con el contenido de los ácidos grasos saturados en B. pinnatum (0,53%), F. exasperata (0,04%) y G. herbaceum (0,47%). Igualmente, el resultado mostró que la H. latifolia contenía el mayor porcentaje de ácidos grasos insaturados con presencia predominante de ácido oleico con una cantidad de 41,04%. También se encontró que el ácido linoleico tiene el valor más alto en H. latifolia con una cantidad de 20,41%. Se encontró ácido esteárico, ácido oleico y ácido linoleico en todas las muestras. El extracto de H. latifolia contenía una mezcla saludable de diferentes tipos de ácidos grasos, lo que sugiere que es una fuente probable de ácidos grasos adecuados.

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Effects of Aqueous Bryophyllum pinnatum Leaf Extract on Hematological, Renal and Sperm Indices in Wistar Rats

Cited by 9 publications

References 20 publications

Nephroprotective effect of Bryophyllum pinnatum‐ mediated silver nanoparticles in ethylene glycol‐induced urolithiasis in rat

Nephroprotective effect of Bryophyllum pinnatum‐ mediated silver nanoparticles in ethylene glycol‐induced urolithiasis in rat

A safety profile of aqueous methanol aerial extract of Alysicarpus glumaceus in mice: acute and subacute administration

Composición de ácidos grasos de extractos etéreos de Bryophyllum pinnatum Lam., Ficus exasperata Vahl., Gossypium herbaceum Linn. y Hilleria latifolia (Lam.) H. Walt

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