Effects of Aqueous Bulb Extract ofAllium sativum(Garlic) on Hematological and Biochemical Parameters in Rabbits: ExperimentalTrypanosoma bruceissp.bruceiInfection

Mikail, Hudu Garba

doi:10.1080/10496470903378979

Cited by 6 publications

(4 citation statements)

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“…Because of its biologically active constituent named "allicin" and its derivative, Allium sativum is used as a medicinal plant for the treatment of a wide range of ailments and disorders related to the heart and blood system, including high blood pressure, high cholesterol, coronary heart disease, heart attack, and atherosclerosis (Mikaili et al, 2013). However, Mikail (2010) reported the presence of phytochemical compounds such as saponins, steroids, tannins, carbohydrates, and cardiac glycosides, which conformed to similar studies by Otunola et al (2010) and Divya et al (2017), who reported the presence of phenolic, alkaloids, flavonoid, saponin, steroid, carotenoids and glycoside which are considered as active medicinal chemical constituents in the A. sativum. Studies on Allium sativum by Touloupakis and Ghanotakis (2010); Nicastro et al (2015), and Divya et al (2017) revealed the existence of essential mineral elements such as Potassium (K), Phosphorus (P), Magnesium (Mg), Calcium (Ca), Zinc (Zn), Aluminium (Al), selenium (Se), iron (Fe) and germanium (Ge) which are vital elements for many regulatory systems in the body, hence increasing its potential as therapeutic agent plant.…”

Section: The Plants Used Against Snakebite and Envenomation In Sub-sa...supporting

confidence: 85%

Medicinal Plants for the Treatment of Snake Envenomation in Sub-Saharan Africa: Opportunities and Challenges

Abduljalil,

Magaji,

Daba

et al. 2023

Nig J Bas App Sci

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Snakes are primarily venomous animals that bite when frightened, which can be lethal. This is because snake venom is one of the most active biological fluids containing a wide range of peptides and proteins that can induce several effects, including hemo-, neuro-, cyto- and myotoxic effects, consequently becoming deleterious to life if untreated. Although snakes are found on almost all continents, the rural communities in sub-Saharan Africa are the most affected by snakebites, mainly due to increased humansnake interactions forced by their socioeconomic status and agricultural or rural practices. Consequently, this recently prompted the World Health Organisation to enlist snakebites envenoming among the category-A neglected tropical diseases with an estimated annual death of 7,300 in sub-Saharan Africa. Aside from mortality, snakebite envenomation also causes permanent disabilities in humans and a heavy burden on livestock, creating economic hardship for the already impoverished communities. Several animal-derived antivenoms have been developed for treating snakebites and wounds; they effectively attenuate venomrelated toxicity, tissue necrosis, and deaths. However, despite the efficacy of these antivenoms, several issues, such as problems in production and distribution, exorbitant prices, and adverse effects of the antivenoms, have challenged their practical use in subSaharan Africa. This review highlights the challenges that make conventional antivenoms unavailable to prone populations. We also discuss the plants used in the treatment of snake bites laying emphasis on Mucuna pruriens (Velvet bean) and Allium sativum (Garlic) as the two most studied medicinal plants. The progress and bottlenecks of using herbal antivenoms as alternatives in treating snakebite envenomation in sub-Saharan Africa are also discussed.

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Section: The Plants Used Against Snakebite and Envenomation In Sub-sa...supporting

confidence: 85%

Medicinal Plants for the Treatment of Snake Envenomation in Sub-Saharan Africa: Opportunities and Challenges

Abduljalil,

Magaji,

Daba

et al. 2023

Nig J Bas App Sci

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“…Mikail reported that there was decrease in the red blood cell in garlic extract and Berenil-treated rabbits group compared to the infected non treated ones [17]. He observed that red blood cells were reduced by the supplementation of garlic intake dose from 7.8 ± 0.25 to 6.4 ± 0.1 (10 6 / mm 3 ).…”

Section: Discussionmentioning

confidence: 95%

Aqueous Garlic Extract; Natural Remedy to Improve Haematological, Renal and Liver Status

Butt¹

2014

J Nutr Food Sci

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Functional foods are gaining popularity worldwide owing to the consumer's preference towards the consumption of natural and safe products in dietary modifications. Garlic (Allium sativum L., Liliaceae.) is an essential vegetable that have been widely utilized as seasoning, flavouring, culinary and in herbal remedies. Garlic is well known to acquire an array of phytochemicals. These bioactive molecules are playing pivotal role in maintaining human health and having potential to reduce various ailments like diabetes, cholesterol, cardiovascular diseases and cancer insurgence. Considering the aim, in vivo study was conducted using New Zeeland type rabbits, providing aqueous garlic extract for a period of 28 days. Accordingly, four groups (G 0 , G 1 , G 2 and G 3) were designed and provide different doses of extract (control, 3, 6 and 9 mL/kg b.w). Functional garlic extract containing water soluble active components resulted in significant reduction in RBC (6.94 ± 0.47 (10 6 /mm 3 in G 2) while WBC improve (16.97 ± 1.70) in G 2. Haemoglobin and haematocrit, packed cell volume, mean corpuscular volume, mean corpuscular haemoglobin and mean corpuscular haemoglobin concentration were also modulated well in G 2 as compare to other groups. Regarding the total protein, maximum was recorded (7.23 ± 0.58) in G 2 while lowest was (6.72 ± 0.15g/L) in G 0. Albumin, globulin and electrolytes like Sodium (Na) and potassium (K) exhibited significant difference by using different concentration of aqueous garlic extract. Moreover, liver functioning test, urea, creatinine, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) also showed significant modulation using the aqueous garlic extract.From the present investigation, it is deduced that garlic preparations like aqueous extract is effective against various maladies because of its functional and nutraceutical aspects.

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“…Due to the known diverse health benefits of garlic, studies had been invested in exploring the role of active phytochemicals (Nazir and Chauhan, 2019;Petropoulos et al, 2018). Phytochemical analysis showed the presence of various bioactive metabolites of diverse compositions such as saponin, tannin, carbohydrates, cardio glycoside, alkaloids, flavonoid, glycoside, and organosulfur compounds encompassing diallyl thiosulfonate (allicin), diallyl sulfide (DAS), diallyl disulfide (DADS), diallyl trisulfide (DATS), E/Z-ajoene, S-allyl-cysteine (SAC), and S-allyl-cysteine sulfoxide (alliin) (Amagase, 2006;Boonpeng et al, 2014;Mikail, 2009;Percival, 2016;Ried and Fakler, 2014;Schäfer and Kaschula, 2014;Seckiner et al, 2014). Amongst all allicin, one of the most important bioactive compounds, is derived in considerable amounts from alliin.…”

Section: Introductionmentioning

confidence: 99%

Novel NARC-G1 garlic: comparative allicin quantification with morpho-biochemical & genetic profiling

et al. 2024

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Garlic (Allium sativum) is an important cash food crop, and the biotechnology industry has considerable interest in the plant because of its medicinal importance. These medicinal properties are attributed to organosulphur compounds as the accumulation of these compounds varies according to genotype, locality, light quality, and cultivation practices. In this study, we compared a newly developed garlic variety NARC-G1 by National Agricultural Research Centre (NARC), Islamabad, Pakistan with three different garlic cultivars and highlighted the distinctive attributes like phenotypic characteristics, the content of allicin, elemental profile, and gene polymorphism. Phenotypic analysis showed NARC-G1 has significantly higher bulb weight (66.36g ± 18.58), single clove weight (5.87g ± 1.041), and clove width (17.41mm ± 0.95) which directly correlates to the size of the garlic. The analytical analysis showed the highest allicin content (4.82 ± 0.001) in NARC-G1. Genotyping of the alliinase in all four cultivars showed indels in the gene resulting in distinguishable changes in organosulphur compounds’ profile. NARC-G1 is unique from other garlic cultivars and could be the best choice for mass production with proper cultivation and irrigation management. Moreover, for Pakistan NARC-G1 could be a potential contender to earn the industrial benefits with inland cultivation instead of importing garlic alleviating the economic burden.

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Effects of Aqueous Bulb Extract ofAllium sativum(Garlic) on Hematological and Biochemical Parameters in Rabbits: ExperimentalTrypanosoma bruceissp.bruceiInfection

Cited by 6 publications

References 10 publications

Medicinal Plants for the Treatment of Snake Envenomation in Sub-Saharan Africa: Opportunities and Challenges

Medicinal Plants for the Treatment of Snake Envenomation in Sub-Saharan Africa: Opportunities and Challenges

Aqueous Garlic Extract; Natural Remedy to Improve Haematological, Renal and Liver Status

Novel NARC-G1 garlic: comparative allicin quantification with morpho-biochemical & genetic profiling

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