Effects of aqueous extract from Apostichopus japonicus on melanogenesis in B16F10 cells and zebrafish

Hsu, Hey‐Chi; Chang, Ting‐Ting; Wang, Yung‐Song

doi:10.1007/s12562-023-01695-5

Cited by 1 publication

(1 citation statement)

References 37 publications

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“…[153] The effects of A. japonicus products on intracellular melanin levels were explored using B16F10 mouse melanoma cells, Melan-A cells, and zebrafish models. A. japonicus viscera extracts (VF), [144] glycoprotein, [55] gelatin (LMW-GH), [89] mixture of A. japonicus extracts (MSCE), [154] and boiled aqueous extracts (SCAE-Tw and SCAE-Jp) [155] inhibit Tyr activity by inhibiting the expression of oxidized glutathione (GSH) by reducing the expression of matrix metalloproteinase-9 (MMP-9) through the extracellular-regulated kinase (ERK) signaling pathway; inhibiting Melan-A cell melanin production; increasing the expression of intracellular GSH; reducing the protein expression levels of Mitf, Tyr, and Tyr-related protein-1 (TRP-1) and -2, and so forth.…”

Section: Effects On the Skinmentioning

confidence: 99%

Chemical substances and their activities in sea cucumber Apostichopus japonicus: A review

Lu,

Wang,

et al. 2023

Archiv der Pharmazie

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Apostichopus japonicus, also known as Stichopus japonicus, with medicinal and food homologous figures, is a globally recognized precious ingredient with extremely high nutritional value. There is no relevant review available through literature search, so this article selects the research articles through the keywords “sea cucumber” and “Apostichopus japonicus (Stichopus japonicus)” in six professional databases, such as Wiley, PubMed, ScienceDirect, ACS, Springer, and Web of Science, from 2000 to the present, summarizing the extraction, isolation, and purification methods for the four major categories (polysaccharides, proteins and peptides, saponins, and other components) of the A. japonicus chemical substances and 10 effective biological activities of A. japonicus. Included are anticoagulation, anticancer/antitumor activities, hematopoiesis, regulation of gut microbiota, and immune regulatory activities that correspond to traditional efficacy. Literature support is provided for the development of medicines and functional foods and related aspects that play a leading role in future directions.

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