Effects of aqueous extract of polyherbal formulation against hyperthyroidism induced by L-thyroxin in a rat model

Ahmed, Sahar B.; Moghazy, Asmaa M.; Ahmed-Farid, Omar A.; Esebery, Hassan A.

doi:10.15419/bmrat.v5i12.506

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…Mice models of different degrees of hyperthyroid liver injury were established by gavage with levothyroxin sodium tablets. , Thirty fourweeks old female Kunming mice were divided into control group, low dose model group and high dose model group with 10 per group after adaptive feeding for 1 week. The low dose model group and high dose model group of mice were continuously administered 400 μL of levothyroxine sodium tablets suspension at the concentration of 50 μg/mL and 100 μg/mL respectively in each morning for 24 days.…”

Section: Experimental Sectionmentioning

confidence: 99%

Evaluating Hyperthyroidism-Induced Liver Injury Based on In Situ Fluorescence Imaging of Glutathione and Phosphate via Nano-MOFs Sensor

Zhang

Wang

et al. 2020

Anal. Chem.

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Hyperthyroidism-induced liver injury is quite common in clinical settings. Therefore, developing rapid and simple methods for the assessment of hyperthyroid liver injury is of great significance. Considering phosphorus metabolism is disordered because of hyperthyroidism, and the hyperthyroid liver injury is closely related to the abnormal level of glutathione (GSH). Thus, development of a new method that can simultaneously detect changes in blood phosphorus and GSH levels of serum, liver, kidney, and other organs to assess the degree of hyperthyroid liver injury is necessary for clinical medical research. Herein, a novel fluorescent metal–organic frameworks (MOFs) nanoprobe using the UiO-66(OH)2 as core and Cu-MOFs as shell was designed and synthesized. Through the specific action between Zr (IV) and phosphate, and the combine interaction of MOFs active center Cu (II) and GSH, high sensitivity and specific fluorescence detection of phosphate and GSH were achieved, respectively. Finally, the nanosensor was applied for evaluating different degrees of hyperthyroid liver injury in mice models and realized the monitoring of serum, liver, kidney, and other organs’ blood phosphorus and GSH levels, and found that the levels of phosphate and GSH in serum were negatively correlated with the degree of hyperthyroid liver injury, while the changes of phosphate and GSH levels in the liver and kidney organs were positively correlated with the degree of hyperthyroid liver injury. In general, the present works provide a new way to effectively evaluate liver injury induced by hyperthyroidism in the early clinical stage.

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Section: Experimental Sectionmentioning

confidence: 99%

Evaluating Hyperthyroidism-Induced Liver Injury Based on In Situ Fluorescence Imaging of Glutathione and Phosphate via Nano-MOFs Sensor

Zhang

Wang

et al. 2020

Anal. Chem.

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“…In a mice study, oral S. costus treatment normalized these lipid abnormalities by reducing plasma LDL cholesterol, possibly through increased LDL receptor activity. 52 A study from Egypt by Sahar et al 54 showed that a polyherb with S. costus “as one of its constituents at low doses” was effective in treating LT4 induced hyperthyroidism in rats and found it to be safer than anti thyroid drug Carbimazole and ameliorated most signalling pathways and in different tissues. These favorable effects of polyherb on thyroid gland may have been induced by flavonoids such as dillapiole, costunolide and caffeic acid by reducing thyroid peroxidase activity.…”

Section: Role Of S Costus In Thyroid Disorders Anmentioning

confidence: 99%

“…Additionally, Tannins like gallic acid and epigallocatechin gallate, which exhibit chelating effect through bonding with inorganic iodide might play a role in ameliorating hyperthyroidism. 54 Another animal study by Han et al 55 in Saudi Arabia assessed the protective effect of aqueous extract of S. costus and showed alleviating toxic effects of pesticide on thyroid gland function. Prior treatment by S. costus extract in pesticide intoxicated rats improved histomorphological changes in thyroid gland and up modulated thyroid hormones suggesting its protective effect against adverse impact of deltamethrin, a pesticide.…”

Section: Role Of S Costus In Thyroid Disorders Anmentioning

confidence: 99%

Clinical significance of Saussurea Costus in thyroid treatment

Mujammami

2020

SMJ

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Saussurea costus (S. costus) belongs to family of Asteraceae and is one of the therapeutic plants extensively used as a traditional medicine in Saudi Arabia. Constituents of this plant have the potential to be developed as bioactive molecules. Among Arabs, the prevalence of thyroid disorders ranges from 6.18 % to 47.34% and hypothyroidism has been reported to be the most prevalent. Although there is no natural treatment that can directly replace thyroid hormones, their role as an alternate treatment or as an add-on to available thyroid treatment has been explored. Flavanoids and antioxidant properties of S. costus may be an important mechanism involved in supporting its medicinal use. Current data on the possible role of S. costus in thyroid disorders is lacking and the available evidence is inconclusive. This review deal with the current understanding of use and myth regarding the use of this medicinal plant in thyroid disease.

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Quercetin alleviates hyperthyroidism‐induced liver damage via Nrf2 Signaling pathway

Zhao

et al. 2020

BioFactors

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Quercetin is a plant flavonoid and has antioxidative properties. In this study, we evaluated the therapeutic effect of quercetin on thyroid dysfunction in L‐thyroxin (LT4)‐induced hyperthyroidism rats. LT4 was used to prepare the experimental hyperthyroidism model via the intraperitoneal injection. Quercetin was injected at a series doses (5, 50, and 100 mg/kg) to LT4‐induced hypothyroidism rats once a day for 14 days. The body weight and food intake were measured once a week. The levels of thyroid hormones, liver function, oxidative stress markers, and antioxidant markers were measured using commercial enzyme‐linked immunosorbent assay kits. Hematoxylin–eosin staining was used to observe the thyroid tissue histological changes. The levels of nuclear and total nuclear factor erythroid 2‐related factor 2 (Nrf2) were determined by western blot. The liver oxidative stress markers in LT4‐induced hyperthyroidism Nrf2 knockout rats were determined to evaluate the role of Nrf2 on quercetin induced protective effects. LT4 administration increased the levels of serum triiodothyronine and thyroxine, activity of oxidative stress markers with a parallel decrease in antioxidant markers and Nrf2. However, the simultaneous administration of quercetin, reversed all these effects indicating its potential in the regulation of hyperthyroidism. Furthermore, the loss function of Nrf2 diminished these effects resulting from the quercetin application, indicating the inhibitory effects caused by the quercetin may be involved in Nrf2 signaling pathway. These results indicate that quercetin could be used to protect against experimental hyperthyroidism‐induced liver damage via Nrf2 signaling pathway.

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Effects of aqueous extract of polyherbal formulation against hyperthyroidism induced by L-thyroxin in a rat model

Cited by 4 publications

References 22 publications

Evaluating Hyperthyroidism-Induced Liver Injury Based on In Situ Fluorescence Imaging of Glutathione and Phosphate via Nano-MOFs Sensor

Evaluating Hyperthyroidism-Induced Liver Injury Based on In Situ Fluorescence Imaging of Glutathione and Phosphate via Nano-MOFs Sensor

Clinical significance of Saussurea Costus in thyroid treatment

Quercetin alleviates hyperthyroidism‐induced liver damage via Nrf2 Signaling pathway

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