Effects of aqueous extracts from Ceratonia siliqua L. pods on small intestinal motility in rats and jejunal permeability in mice

Rtibi, Kaïs; Selmi, Slimen; Jabri, Mohamed-Amine; Mamadou, Godefroy; Limas-Nzouzi, Nicolas; Sebaï, Hichem; El-Benna, Jamel; Marzouki, Lamjed; Eto, Bruno; Amri, Mohamed

doi:10.1039/c6ra03457h

Cited by 35 publications

(35 citation statements)

References 42 publications

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“…This action of intestinal transit facilitation can also be exhibited by the increase effect in intestinal secretion. In this context, similar results were previously published by Rtibi and others () who have shown that the aqueous extract of mature carob pulp causes an increase in intestinal secretion which facilitates the gastrointestinal transit. These findings providing direct evidence that the mature juice of prickly pear fruit exerts a favorable laxative effect.…”

Section: Discussionsupporting

confidence: 89%

Reverse Effect ofOpuntia ficus‐indicaL. Juice and Seeds Aqueous Extract on Gastric Emptying and Small‐Bowel Motility in Rat

Rtibi

Selmi

Saidani

et al. 2017

Journal of Food Science

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This study was conducted to compare the effects of juice and seeds on gastric emptying, small-bowel motility and intestinal ion transport. Separate groups of rats were randomized to receive NaCl, increasing doses of juice (5, 10, and 20 mL/kg, b.w.) or seeds aqueous extract (100, 200, and 400 mg/kg, b.w.). Simultaneously, two other groups were received, the reference drugs; clonidine (1 mg/kg) and yohimbine (2 mg/kg). The charcoal meal was used as a suspension for gastrointestinal motility test. The purgative action of juice was confirmed using the loperamide (5 mg/kg, p.o.) induced constipation. To evaluate the antisecretory effect, we were used as a hypersecretion agent, the castor oil at the dose of 5 mL/kg. Compared to the control and standard groups, we were showed that the prickly pear has an opposite effect on small-bowel motility and gastric emptying. Indeed, the juice at various doses has a laxative effect of gastrointestinal transit in healthy and constipated-rats. However, the aqueous extract of the seeds leads to a reduction of motility in normal rats which gives it a remarkable antidiarrhoeal activity, a notable intestinal fluid accumulation decline and electrolyte concentrations reestablishment. Moreover, orally juice administered at different doses accelerated the stomach emptying time in contrast to the seeds aqueous extract. More importantly, a significant variation in the phytochemical constituents levels between juice and seeds was found. These findings confirm the reverse therapeutic effects of this fruit in the treatment of digestive disturbances such as difficulty stool evacuation and massive intestinal secretion, likewise, the gastric emptying process perturbation.

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Section: Discussionsupporting

confidence: 89%

Reverse Effect ofOpuntia ficus‐indicaL. Juice and Seeds Aqueous Extract on Gastric Emptying and Small‐Bowel Motility in Rat

Rtibi

Selmi

Saidani

et al. 2017

Journal of Food Science

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“…One of these compounds is pyrogallol (1,2,3-trihydroxy benzene). 158 A short summary of these activities can be found in a recent review article that was published by I. C. Theophilou and her colleagues.…”

Section: Discussionmentioning

confidence: 99%

“…102 Carob extracts are being studied in recent years for gastroprotective activities, and they were found highly active, so far. [155][156][157][158][159] Most studies were done in vivo after induction of gastric disorder in animals. These diorders were induced by various chemicals such as ethanol, hydrochloric acid, sodium chloride or dextran sulfate sodium.…”

Section: Discussionmentioning

confidence: 99%

“…It was also tested against small intestinal motility in rats and jejunal permeability in mice, and found active in both tests. 158 Soluble galactomannans were water extracted from Carob seeds, and formulated to treat gastric reflux of infants. Results were positive after three days treatment.…”

Section: Gastroprotection and Other Digestive System Related Activitiesmentioning

confidence: 99%

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CAROB (Ceratonia siliqua): HEALTH, MEDICINE, CHEMISTRY

Azab¹

2017

ECB

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“…siliqua pods are used in various regions of the world including Pakistan for the treatment of diarrhea and constipation by traditional medicine practitioner. Recently a scientific in vivo study was conducted on immature and mature carob pods which claimed that phytochemical constituent(s) variations in immature and mature carob pods play a role in the management of diarrhea and constipation (Rtibi et al, 2016b).…”

Section: Discussionmentioning

confidence: 99%

Ethnopharmacological basis for antispasmodic, antidiarrheal and antiemetic activities of Ceratonia siliqua pods

Hamid

Janbaz

2017

Bangladesh J Pharmacol

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The study was conducted to provide the ethnopharmacological bases of the crude extract of seed pods of Ceratonia siliqua in the gastrointestinal spasm, diarrhea and emesis. In segregated rabbit jejunum, it showed dose-dependent (0.01-10 mg/mL) relaxation of spontaneous as well as carbachol (1 µM)-induced contraction. Pre-treatment of segregated rat ileum with C. siliqua, significantly (p<0.0001) suppressed the carbachol (1 µM)-induced contraction similar to atropine (1 µM). These results indicated that C. siliqua possesses spasmolytic activity through possible blockage of muscarinic receptor in jejunum preparations. Furthermore, the crude extract inhibited the castor oil-induced diarrhea, charcoal meal propulsion in mice and copper sulfate-induced retches in chicks in a dose-dependent manner (100, 200, 300 mg/kg). These in vitro and in vivo results indicate that C. siliqua possesses the spasmolytic and antidiarrheal activities mediated possibly through blockage of muscarinic receptors. Thus, this study provides a rationale for its folkloric use.Video Clip of Methodology:12 min 42 sec <a href="https://www.youtube.com/v/BQGWdIZqpsY">Full Screen</a> <a href="https://www.youtube.com/watch?v=BQGWdIZqpsY">Alternate</a>

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Effects of aqueous extracts from Ceratonia siliqua L. pods on small intestinal motility in rats and jejunal permeability in mice

Abstract: The current study was performed to assess the effects of carob pod aqueous extracts (CPAE, pulp, seeds or mixture) on gastrointestinal transit (GIT) and intestinal epithelium permeability.

Cited by 35 publications

References 42 publications

Reverse Effect ofOpuntia ficus‐indicaL. Juice and Seeds Aqueous Extract on Gastric Emptying and Small‐Bowel Motility in Rat

Reverse Effect ofOpuntia ficus‐indicaL. Juice and Seeds Aqueous Extract on Gastric Emptying and Small‐Bowel Motility in Rat

CAROB (Ceratonia siliqua): HEALTH, MEDICINE, CHEMISTRY

Ethnopharmacological basis for antispasmodic, antidiarrheal and antiemetic activities of Ceratonia siliqua pods

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