Effects of aqueous stable fullerene nanocrystals (nC60) on Daphnia magna: Evaluation of sub-lethal reproductive responses and accumulation

Xie, Tao; Fortner, John D.; Zhang, Bo; He, Yiliang; Chen, Yongsheng; Hughes, Joseph B.

doi:10.1016/j.chemosphere.2009.10.027

Cited by 81 publications

(56 citation statements)

References 43 publications

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“…Additionally, fullerene accumulations within the gut lumen appeared to be limited by the size of the gut rather than the aqueous-phase concentration, again suggesting minimal systemic absorption into the organism. In one study with fullerenes dispersed using THF and with the THF byproducts subsequently removed, substantial maternal transfer of the fullerenes was reported for Daphnia magna [103]. These authors removed excess THF byproducts prior to the Daphnia exposures, but it is unclear whether the THF dispersion process influenced the surface chemistry of the fullerene aggregates in some unique way or whether these fullerenes had some toxic effect on the Daphnia that allowed for their transfer to the embryos.…”

Section: Lack Of Cnp Absorption Into Tissuesmentioning

confidence: 99%

“…Several procedures are available to identify fullerenes in Daphnia by extracting the fullerenes and then measuring absorbance of their characteristic peaks using UV/vis spectroscopy [79,102,103]. However, these approaches may not work with larger organisms in which these extraction techniques also remove large quantities of other biomolecules such as lipids, which may hinder the detection of the fullerenes by spectroscopic methods.…”

Section: Methods Of Cnp Analysis In Other Matricesmentioning

confidence: 99%

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Methodological considerations for testing the ecotoxicity of carbon nanotubes and fullerenes: Review

Petersen

Henry

2011

Enviro Toxic and Chemistry

114

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Abstract-The recent emergence of manufactured nanoparticles (NPs) that are released into the environment and lead to exposure in organisms has accelerated the need to determine NP toxicity. Techniques for measuring the toxicity of NPs (nanotoxicology) in ecological receptors (nanoecotoxicology) are in their infancy, however, and establishing standardized ecotoxicity tests for NPs are presently limited by several factors. These factors include the extent of NP characterization necessary (or possible) before, during, and after toxicity tests such that toxic effects can be related to physicochemical characteristics of NPs; determining uptake and distribution of NPs within exposed organisms (does uptake occur or are effects exerted at organism surfaces?); and determining the appropriate types of controls to incorporate into ecotoxicity tests with NPs. In this review, the authors focus on the important elements of measuring the ecotoxicity of carbon NPs (CNPs) and make recommendations for ecotoxicology testing that should enable more rigorous interpretations of collected data and interlaboratory comparisons. This review is intended to serve as a next step toward developing standardized tests that can be incorporated into a regulatory framework for CNPs. Environ. Toxicol. Chem.

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Section: Lack Of Cnp Absorption Into Tissuesmentioning

confidence: 99%

Section: Methods Of Cnp Analysis In Other Matricesmentioning

confidence: 99%

Methodological considerations for testing the ecotoxicity of carbon nanotubes and fullerenes: Review

Petersen

Henry

2011

Enviro Toxic and Chemistry

114

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“…C 60 fullerenes administration increased the hepatic 8-oxodG level and high dose generated 8-oxodG in the lung [206]. In oysters they are known for affecting oyster embryonic development, cellular damage in the alimentary canal in Daphnia magna, growth inhibition in freshwater fish Carassius auratus, increase in mortality rates in gestating daphnids, nitric oxide production in Mytilus hemocytes [211][212][213][214][215].…”

Section: Mechanistic Studiesmentioning

confidence: 99%

In vitro and in vivo toxicity assessment of nanoparticles

2017

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Nanotechnology has revolutionized gene therapy, diagnostics and environmental remediation. Their bulk production, uses and disposal have posed threat to the environment. With the appearance of these nanoparticles in the environment, their toxicity assessment is an immediate concern. This review is an attempt to summarize the major techniques used in cytotoxity determination. The review also presents a detailed and elaborative discussion on the toxicity imposed by different types of nanoparticles including carbon nanotubes, gold nanoparticles, silver nanoparticles, quantum dots, fullerenes, aluminium nanoparticles, zinc nanoparticles, iron nanoparticles, titanium nanoparticles and silica nanoparticles. It discusses the in vitro and in vivo toxological effects of nanoparticles on bacteria, microalgae, zebrafish, crustacean, fish, rat, mouse, pig, guinea pig, human cell lines and human. It also discusses toxological effects on organs such as liver, kidney, spleen, sperm, neural tissues, liver lysosomes, spleen macrophages, glioblastoma cells, hematoma cells and various mammalian cell lines. It provides information about the effects of nanoparticles on the gene-expression, growth and reproduction of the organisms.

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“…The sorption of PAHs to nC 60 resulted in a remarkable decline of their C free , suggesting a reduced diffusive uptake of non-bound HOCs even at relatively low concentrations of nC 60 . However, an increasing number of studies have shown that C 60 fullerene and fullerene derivatives can traverse cell membranes (Foley et al, 2002;Rouse et al, 2007) and accumulate in living organisms (Oberdorster et al, 2006;Tao et al, 2009;Xia et al, 2009), which suggested that HOCs may also be transported when bound to the nC 60 . Additionally, just as the artificial and natural organic matter, nC 60 may also enhance the diffusive mass transfer of the HOCs through the aqueous boundary layer at the organisms (Mayer et al, 2007;ter Laak et al, 2009), which is often considered the rate-limiting step for diffusive uptake (Sijm and Vanderlinde, 1995).…”

Section: Introductionmentioning

confidence: 99%

“…Fullerene could enter living organisms via several routes, especially the respiratory and digestive systems and the skin (Oberdorster et al, 2005). Various studies have demonstrated that carbon nanomaterials (CNMs), including fullerene, can penetrate both cell membranes (Foley et al, 2002) and living tissues (Rouse et al, 2007;Xia et al, 2009), and cause both in vitro (Wang et al, 2009(Wang et al, , 2010 and in vivo (Oberdorster et al, 2006;Tao et al, 2009) toxicity. New insights in nanotoxicity suggest that the toxicity of CNMs is due not only to their own intrinsic toxicity, but also to the effect of these CNMs on the fate, transport and exposure of toxic substances (Colvin, 2003;Yang et al, 2006;Xia et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Bioavailability of organochlorine compounds in aqueous suspensions of fullerene: Evaluated with medaka (Oryzias latipes) and negligible depletion solid-phase microextraction

Liu

Zhou

et al. 2010

Chemosphere

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a b s t r a c tThe wide application of engineered nanomaterials, such as fullerene (C 60 ), will inevitably lead to their release into the aqueous environment, which may alter the bioavailability of organic compounds to aquatic organisms. Negligible depletion solid-phase microextraction (nd-SPME) together with medaka (Oryzias latipes) bioaccumulation were used to study the effects of aqueous suspensions of fullerene (nC 60 ) on the bioavailability of eight organochlorine compounds (OCCs) (log K OW 3.76-6.96). Freely dissolved concentrations of OCCs decreased by 11.5-88.4% at addition of 5 mg L À1 nC 60 as indicated by reduced equilibrium concentrations in the SPME fiber coating, the highest reduction being observed for the most hydrophobic OCCs. Medaka bioaccumulation study demonstrated that at the kinetic uptake regime, nC 60 significantly decreased the bioaccumulation of the high hydrophobic OCCs (log K OW > 6), but slightly enhanced the bioaccumulation of the less hydrophobic OCCs (log K OW < 6). The OCC concentrations in medaka (C fish ) at the kinetic uptake regime linearly correlated with that in nd-SPME fiber (C fiber ) without nC 60 (p = 0.007-0.013, R 2 = 0.666-0.723), but this correlation deteriorated with the presence of nC 60 (p = 0.073-0.081, R 2 = 0.423-0.440). These results suggest that in nC 60 the uptake mechanism of OCCs to medaka is different from that to nd-SPME fiber. While only the freely dissolved OCCs are available to nd-SPME fiber, both the freely dissolved and the nC 60 associated OCCs contributed to the accumulation of OCCs to medaka.

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Effects of aqueous stable fullerene nanocrystals (nC60) on Daphnia magna: Evaluation of sub-lethal reproductive responses and accumulation

Cited by 81 publications

References 43 publications

Methodological considerations for testing the ecotoxicity of carbon nanotubes and fullerenes: Review

Methodological considerations for testing the ecotoxicity of carbon nanotubes and fullerenes: Review

In vitro and in vivo toxicity assessment of nanoparticles

Bioavailability of organochlorine compounds in aqueous suspensions of fullerene: Evaluated with medaka (Oryzias latipes) and negligible depletion solid-phase microextraction

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