2002
DOI: 10.1007/s726-002-8200-9
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Effects of arginine, L-alanyl-L-glutamine or taurine on neutrophil (PMN) free amino acid profiles and immune functions in vitro

Abstract: The objective of this study was to determine the effects of arginine, L-alanyl-L-glutamine (Ala-Gln) or taurine on polymorphonuclear leucocyte (PMN) free amino acid profiles, superoxide anion (O2-) generation, hydrogen peroxide (H2O2) formation and released myeloperoxidase activity (MPO). Arginine led to significant increases in PMN arginine, ornithine, citrulline, aspartate, glutamate and alanine concentrations as well as increased H2O2-generation and MPO activity while O(2-)-formation was decreased. Ala-Gln … Show more

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Cited by 29 publications
(22 citation statements)
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“…The significant decline in amino acid concentration after cell induction observed in the present experiment (Tables 1 and 2), is consistent with earlier studies on mammalian cells [5,32]. In the present study, it should be noted that 21 amino acids accounted for most of media amino acid losses during lymphocyte proliferation, compared to only 12 amino acids during the bacterial killing process.…”
Section: Discussionsupporting
confidence: 93%
“…The significant decline in amino acid concentration after cell induction observed in the present experiment (Tables 1 and 2), is consistent with earlier studies on mammalian cells [5,32]. In the present study, it should be noted that 21 amino acids accounted for most of media amino acid losses during lymphocyte proliferation, compared to only 12 amino acids during the bacterial killing process.…”
Section: Discussionsupporting
confidence: 93%
“…α-ketoglutarate, pyruvate) appear to have significant metabolic and nutritional functions in leukocytes. More than that, the composition of free intracellular amino acid and α-ketoacid pools in body cells do not seem to be arbitrary in any direction, but may rather represent a relevant metabolic correlate, a quasi-immunonutritional metabolic fingerprint, for the underlying functions [24]- [26]. It is thus not surprising that scientific interest here also focused on the possibility to use selected amino-or ketoacids as part of a "standard" diet therapeutically [27]- [29].…”
Section: Discussionmentioning
confidence: 99%
“…Some authors have shown that arginine intake improves the immune response, especially that dependent on T-cell activity, as shown by an increased response to concanavalin A, phytohemagglutinin and allogenic target cells (Efron & Barbul, 2000;Alexander, 2002;Muhling et al, 2002). Although some experimental studies have suggested that the use of arginine as a supplement leads to clinical benefits in critically ill patients (Muhling et al, 2002;Lesourd, 2004), there is a lack of studies about the potential benefits of any nutrients supplementation after pneumococcal immunization of older persons, free-living in the community.…”
Section: Introductionmentioning
confidence: 99%
“…Although some experimental studies have suggested that the use of arginine as a supplement leads to clinical benefits in critically ill patients (Muhling et al, 2002;Lesourd, 2004), there is a lack of studies about the potential benefits of any nutrients supplementation after pneumococcal immunization of older persons, free-living in the community. Considering the individual variation in the immune response to pneumococcal vaccine and the reported benefits of arginine supplementation for immune function, this study intended to verify whether or not oral arginine supplementation affects the humoral response against the pneumococcal polysaccharide vaccine and some variables of the innate immune response in a group of persons aged 60 y and older, living in the community.…”
Section: Introductionmentioning
confidence: 99%