2017
DOI: 10.15666/aeer/1503_9991012
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Effects of Aroclor 1254 on the Dna Methylation of Imprinted Genes in the Adult Mouse Sperm

Abstract: Abstract. As estrogen-like and anti-androgenic endocrine-disrupting chemicals, polychlorinated biphenyls have been reported to affect the male reproductive axis resulting in infertility. In the present study, Aroclor 1254 was administered to adult male mice, and its possible effects on the differentially methylated regions of two paternally (H19 and Gtl2) and three maternally (Mest, Snrpn and Igf2r) imprinted genes were tested in the sperm DNA. In the control, the percentages of methylated CpGs were close to 1… Show more

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“…Male reproductive disorders, such as a diminution in sperm quality and quantity, have shown an increasing trend in recent years. Several environmental/lifestyle factors (like exposure to dioxins, traffic exhaust fumes, smoking, and obesity) appear to negatively affect both the perinatal and adult testes (Sharpe, 2010;Wang et al, 2017). TCDD was found to increase oxidative stress and inhibit the activity of the antioxidant enzymes in testis and influences the serum level of testosterone hormone.…”
Section: Discussionmentioning
confidence: 99%
“…Male reproductive disorders, such as a diminution in sperm quality and quantity, have shown an increasing trend in recent years. Several environmental/lifestyle factors (like exposure to dioxins, traffic exhaust fumes, smoking, and obesity) appear to negatively affect both the perinatal and adult testes (Sharpe, 2010;Wang et al, 2017). TCDD was found to increase oxidative stress and inhibit the activity of the antioxidant enzymes in testis and influences the serum level of testosterone hormone.…”
Section: Discussionmentioning
confidence: 99%