Effects of arotinolol on exercise capacity and humoral factors during exercise in normal subjects

Abstract

A placebo-controlled, double-blind crossover study was undertaken in 10 normal subjects to examine the effects of arotinolol (10 mg bid), a nonselective beta blocker with alpha-blocking activity, on exercise capacity and hormone levels during exercise after a 2-week treatment period. Maximal oxygen uptake (VO2 max) and blood lactic acid concentration (LA) were measured during progressive exercise testing. An exercise intensity equivalent to 4 mmol/l of LA was used for the constant workload exercise test. Humoral factors were measured after 20 minutes of constant workload exercise. The administration of arotinolol significantly decreased systolic blood pressure and heart rate at rest and during exercise, but diastolic blood pressure did not change. No significant difference was found between arotinolol and placebo with regard to VO2 max and maximal workload. Plasma renin activity (PRA), aldosterone (PAC), and norepinephrine (NE) levels at rest and during exercise did not differ between the two treatments. In contrast, plasma epinephrine (EN) levels at rest and during exercise were significantly greater with arotinolol. Atrial natriuretic peptide (ANP) at rest did not differ between the two treatments. However, exercise caused a significant increase in ANP after arotinolol treatment. These findings suggest that arotinolol decreases blood pressure and heart rate without affecting exercise capacity.

Copper-Catalyzed Three-Component Synthesis of β-Hydroxysulfides from Styrene Oxide, Aryl Iodide, and Carbon Disulfide

“…1 H NMR (400 MHz, chloroform-d) δ 7.75−7.66 (m, 1H), 7.63−7.56 (m, 1H), 7.48−7.42 (m, 2H), 7.39− 7.34 (m, 2H), 7.31−7.28 (m, 1H), 7.16−7.11 (m, 1H), 5.28 (s, 1H), 5.17 (dd, J = 8.1, 2.8 Hz, 1H), 3.66 (dd, J = 14.5, 3.0 Hz, 1H), 3.52 (dd, J = 14.5, 8.0 Hz, 1H), 2.46 (s, 3H). 13 3.72 (dd, J = 14.4, 3.1 Hz, 1H), 3.55 (dd, J = 14.6, 7.9 Hz, 1H). 13 thiazol-2-yl)thio)-1-phenylethan-1-ol (5ab).…”

“…2 For example, arotinolol can decrease blood pressure and heart rate without affecting exercise capacity. 3 Embeconazole can be used as a novel antifungal lead compound. 4 Luprostiol can effectively induce delivery in goats.…”

“…Among them, β-hydroxysulfides are of particular importance due to widespread applications as valuable synthetic blocks and various biological activities in drug discovery . For example, arotinolol can decrease blood pressure and heart rate without affecting exercise capacity . Embeconazole can be used as a novel antifungal lead compound .…”