Effects of arsenic exposure on trace element levels in the hippocampus and cortex of rats and their gender differences

Yan, Xi; Zhang, Jun; Li, Junyu; Zhang, Xinglai; Wang, Yi; Chen, Xiaolu; Luo, Peng; Hu, Ting; Cao, Xueshan; Zhuang, Hongbin; Tang, Xiaoxiao; Yao, Fang; He, Zhijun; Ma, Guanwei; Ran, Xiaoqian; Shen, Liming

doi:10.1016/j.jtemb.2023.127289

Cited by 5 publications

(1 citation statement)

References 91 publications

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“…However, more experiments are needed to confirm and explain the mechanisms leading to these differences [214,215].…”

Section: Morphological Alterations Induced By As Exposurementioning

confidence: 99%

Mechanisms Associated with Cognitive and Behavioral Impairment Induced by Arsenic Exposure

Vázquez Cervantes,

González Esquivel,

Ramírez Ortega

et al. 2023

Cells

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Arsenic (As) is a metalloid naturally present in the environment, in food, water, soil, and air; however, its chronic exposure, even with low doses, represents a public health concern. For a long time, As was used as a pigment, pesticide, wood preservative, and for medical applications; its industrial use has recently decreased or has been discontinued due to its toxicity. Due to its versatile applications and distribution, there is a wide spectrum of human As exposure sources, mainly contaminated drinking water. The fact that As is present in drinking water implies chronic human exposure to this metalloid; it has become a worldwide health problem, since over 200 million people live where As levels exceed safe ranges. Many health problems have been associated with As chronic exposure including cancer, cardiovascular diseases, gastrointestinal disturbances, and brain dysfunctions. Because As can cross the blood–brain barrier (BBB), the brain represents a target organ where this metalloid can exert its long-term toxic effects. Many mechanisms of As neurotoxicity have been described: oxidative stress, inflammation, DNA damage, and mitochondrial dysfunction; all of them can converge, thus leading to impaired cellular functions, cell death, and in consequence, long-term detrimental effects. Here, we provide a current overview of As toxicity and integrated the global mechanisms involved in cognitive and behavioral impairment induced by As exposure show experimental strategies against its neurotoxicity.

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“…However, more experiments are needed to confirm and explain the mechanisms leading to these differences [214,215].…”

Section: Morphological Alterations Induced By As Exposurementioning

confidence: 99%

Mechanisms Associated with Cognitive and Behavioral Impairment Induced by Arsenic Exposure

Vázquez Cervantes,

González Esquivel,

Ramírez Ortega

et al. 2023

Cells

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Effects of arsenic exposure on blood trace element levels in rats and sex differences

Ran,

Yan,

Zhuang

et al. 2024

Biometals

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Integration of proteomics and metabolomics analysis investigate mechanism of As-induced immune injury in rat spleen

Ran,

Yan,

et al. 2024

Ecotoxicology and Environmental Safety

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Effects of arsenic exposure on trace element levels in the hippocampus and cortex of rats and their gender differences

Cited by 5 publications

References 91 publications

Mechanisms Associated with Cognitive and Behavioral Impairment Induced by Arsenic Exposure

Mechanisms Associated with Cognitive and Behavioral Impairment Induced by Arsenic Exposure

Effects of arsenic exposure on blood trace element levels in rats and sex differences

Integration of proteomics and metabolomics analysis investigate mechanism of As-induced immune injury in rat spleen

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