Effects of Artemisia pallens Wall. on blood glucose levels in normal and alloxan-induced diabetic rats

Subramoniam, A.; Pushpangadan, P.; Rajasekharan, S.; Da, Evans; Latha, P. G.; Valsaraj, R.

doi:10.1016/0378-8741(95)01329-6

Cited by 103 publications

(43 citation statements)

References 3 publications

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“…8,9) Many indigenous Indian medicinal plants have been found to be useful to successfully manage diabetes. [10][11][12] Despite the introduction of hypoglycemic agents from natural and synthetic sources, diabetes and its secondary complications continue to be a major problem in the world population. Eugenia jambolana LAM (Fam: Myrtaceae) is commonly called as Jamun, Black plum or Indian Black berry.…”

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confidence: 99%

Protective Effect of Eugenia jambolana Seed Kernel on Tissue Antioxidants in Streptozotocin-Induced Diabetic Rats

Ravi

Balasubramanian

Subramanian

2004

Biological & Pharmaceutical Bulletin

168

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Preparation of Plant ExtractThe fruits of jambolana were first washed well and pulp was removed from the seeds. Seeds were washed several times with distilled water to remove the traces of pulp from the seeds. The seeds were dried at room temperature. The kernel of the seeds was selectively separated from the seed coat. The kernel was powdered in an electrical grinder and stored at 5°C until further use. Kernel powder (100 g) was extracted with petroleum ether (60-80°C) to remove lipids. It was then filtered and the residue was extracted with 95% ethanol by Soxhlation. Ethanol was evaporated in a rotary evaporator at 40-50°C under reduced pressure. The yield of kernel was Ϫ3.2 g/100 g. Animals Male albino Wistar rats, weighing about 150-180 g obtained from Tamil Nadu Veterinary and Animal Sciences University, Chennai, India were used for the present investigations. The animals were maintained on standard rat Oxidative stress plays an important role in chronic complications of diabetes. In the present study the antioxidant effect of oral administration of ethanolic extract of Eugenia jambolana seed kernel on tissue antioxidant enzymes and lipid peroxidation in liver and kidney of streptozotocin-induced diabetic rats was evaluated. Administration of seed kernel to diabetic rats significantly decreased the levels of blood glucose, glycosylated hemoglobin and increased body weight gain, plasma insulin and hemoglobin. The diabetic rats showed the low activities of superoxide dismutase, catalase, glutathione peroxidase and reduced glutathione content in liver and kidney, which were restored to near normal levels by treatment with the seed kernel extract. The increased levels of lipid peroxidation and hydroperoxides in diabetic rats were reverted back to near normal levels after the treatment with seed kernel extract. Diabetic rats treated with seed kernel extract restored almost normal architecture of liver and kidney and were confirmed by histopathological examination. The present study reveals the efficacy of Eugenia jambolana seed kernel in the amelioration of diabetes, which may be attributed to its hypoglycemic property along with its antioxidant potential. The antioxidant effect of Eugenia jambolana seed kernel was also compared with glibenclamide, a standard hypoglycemic drug.

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confidence: 99%

Protective Effect of Eugenia jambolana Seed Kernel on Tissue Antioxidants in Streptozotocin-Induced Diabetic Rats

Ravi

Balasubramanian

Subramanian

2004

Biological & Pharmaceutical Bulletin

168

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“…Because many synthetic antioxidants (butylated hydroxyanisole and butylated hydroxytoluene) have been proved to have undesirable side effects [19]. There has been an increasing interest in the use of medicinal plants rich in antioxidants to reduce free radicalsinduced tissue injury [20].…”

Section: Discussionmentioning

confidence: 99%

The Potential Anti Helicobacter pylori and antioxidant effects of Artemisia Judaica

El‐Sayed

BaAbbad

Balash

et al. 2013

FFHD

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Artemisia judaica (AJ) is one of the common species of the genus Artemisia that grows in Saudi Arabia desert and Sinai, Egypt where animals graze on it. It is widely used in traditional medicine and by Bedouins there. (AJ) has anthelmintic, antibacterial, antiinflammatory, analgesic and antipyretic effects. The present study aimed to (1) elucidates the antibacterial action of AJ against H. pylori and different other bacterial species (2) delineate the potential antibacterial mechanism of action of AJ in comparison with tetracycline and cefotaxime (3) measure the trolox equivalent antioxidant capacity (TEAC) of the AJ water extract. Preparation of the (AJ) extracts was done by three different methods two of them are usually performed by population in Middle East by boiling of the shade-dried herb in water as tea (decoction), or soaked in tap water for over night (infusion), other method was done by concentrating the aqueous extract of Artemisia judaica under vacuum. The results of this study revealed that (AJ) has neither antibacterial effects either against H. pylori nor any other bacterial species. On the other hand the extract of AJ prepared by any of the above mentioned methods shows significant (p<0.005) antioxidant action as compared with blank and related to trolox antioxidant capacity.

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“…There are 32 species belonging to the genus Artemisia L. of family Asteraceae, growing in different zones of India. The anti-pyretic, anti-inflammatory, anthelmintic, anti-malarial, anti-diabetic, and anti-microbial effects of A. pallens make it an medicinally important plant (Subramoniam et al 1996;Haider et al 2014). Recently, anti-malarial property has been reported in two other species of Artemisia, A. japonica and A. nilagirica (Shukla et al 2015).…”

Section: Introductionmentioning

confidence: 99%

In vitro regeneration and optimization of factors affecting Agrobacterium mediated transformation in Artemisia Pallens, an important medicinal plant

Alok

Shukla

Pala

et al. 2016

Physiol Mol Biol Plants

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Artemisia pallens is an important medicinal plant. In-vitro regeneration and multiplication of A. pallens have been established using attached cotyledons. Different growth regulators were considered for regeneration of multiple shoots. An average of 36 shoots per explants were obtained by culturing attached cotyledons on Murashige and Skoog's medium containing 2 mg/L BAP and 0.1 mg/L NAA, after 45 days. The shoots were rooted best on half Murashige and Skoog's medium with respect to media containing 1 mg/L IBA or 1 mg/L NAA. Different parameters such as type of bacterial strains, OD 600 of bacterial culture, co-cultivation duration, concentration of acetosyringone and explants type were optimized for transient expression of the reporter gene. Agrobacterium tumefaciens harbouring pCambia1301 plasmid carrying β-glucuronidase as a reporter gene and hygromycin phosphotransferase as plant selectable marker genes were used for genetic transformation of A. pallens. Hygromycin lethality test showed concentration of 15 mg/L were sufficient to inhibit the growth of attached cotyledons and multiple shoot buds of nontransgenics in selection media.Up to 83 % transient transformation was found when attached cotyledons were co-cultivated with Agrobacterium strain AGL1 for 2 days at 22°C on shoot induction medium. The bacterial growth was eliminated by addition of cefotaxime (200 mg/L) in selection media. T 0 transgenic plants were confirmed by GUS histochemical assay and further by polymerase chain reaction (PCR) using uidA and hpt gene specific primers. The study is useful in establishing technological improvement in A. pallens by genetic engineering.

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Effects of Artemisia pallens Wall. on blood glucose levels in normal and alloxan-induced diabetic rats

Cited by 103 publications

References 3 publications

Protective Effect of Eugenia jambolana Seed Kernel on Tissue Antioxidants in Streptozotocin-Induced Diabetic Rats

Protective Effect of Eugenia jambolana Seed Kernel on Tissue Antioxidants in Streptozotocin-Induced Diabetic Rats

The Potential Anti Helicobacter pylori and antioxidant effects of Artemisia Judaica

In vitro regeneration and optimization of factors affecting Agrobacterium mediated transformation in Artemisia Pallens, an important medicinal plant

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