Effects of articaine and ropivacaine on calcium handling and contractility in canine ventricular myocardium

Szentandrássy, Norbert; Szabó, Ágnes; Almássy, János; Jóna, István; Horváth, Balázs; Szabó, Gergely; Bányász, Tamás; Márton, Ildikó; Nánási, Péter P.; Magyar, János

doi:10.1097/eja.0b013e328331a37b

Cited by 7 publications

(6 citation statements)

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“…Besides sarcoplasmic reticulum calcium release, sarcoplasmic reticulum calcium reuptake was blockade and calcium sensitivity of the contractile system was increased with racemic bupivacaine and its isomers, displaying a stereoselectivity to S(-)bupivacaine and leading to myocardial relaxation slowness 7,14 . It was also demonstrated high ropivacaine concentrations caused L-type calcium channel blockade, leading to negative inotropic effects in canine ventricular muscle 15 .…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies demonstrated negative inotropic effects with different LA 8,[13][14][15] . Divergent LA concentrations were described to induce myocardial contractile function impairment.…”

Section: Discussionmentioning

confidence: 99%

“…been reported to cause negative inotropic effects with 100 to 1.000 mM 15 . Myocardial relaxation was also impaired by LA 8 .…”

Section: Discussionmentioning

confidence: 99%

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Myocardial contractility impairment with racemic bupivacaine, non-racemic bupivacaine and ropivacaine. A comparative study

et al. 2015

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Brazil. Conception, design, intellectual and scientific content of the study; critical revision; final approval. ABSTRACT PURPOSE:To study racemic bupivacaine, non-racemic bupivacaine and ropivacaine on myocardial contractility. METHODS:Isolated Wistar papillary muscles were submitted to 50 and 100 mM racemic bupivacaine (B50 and B100), non-racemic bupivacaine (NR50 and NR100) and ropivacaine (R50 and R100) intoxication. Isometric contraction data were obtained in basal condition (0.2 Hz), after increasing the frequency of stimulation to 1.0 Hz and after 5, 10 and 15 min of local anesthetic intoxication.Data were analyzed as relative changes of variation. RESULTS:Developed tension was higher with R100 than B100 at D1 (4.3 ± 41.1 vs -57.9 ± 48.1). Resting tension was altered with B50 (-10.6 ± 23.8 vs -4.7 ± 5.0) and R50 (-14.0 ± 20.5 vs -0.5 ± 7.1) between D1 and D3. Maximum rate of tension development was lower with B100 (-56.6 ± 38.0) than R50 (-6.3 ± 37.9) and R100 (-1.9 ± 37.2) in D1. B50, B100 and NR100 modified the maximum rate of tension decline from D1 through D2. Time to peak tension was changed with NR50 between D1 and D2. CONCLUSIONS:Racemic bupivacaine depressed myocardial contractile force more than non-racemic bupivacaine and ropivacaine.Non-racemic and racemic bupivacaine caused myocardial relaxation impairment more than ropivacaine.Key words: Anesthetics, Local. Cardiotoxicity. Papillary Muscles. Rats. Myocardial contractility impairment with racemic bupivacaine, non-racemic bupivacaine and ropivacaine. A comparative study

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Myocardial contractility impairment with racemic bupivacaine, non-racemic bupivacaine and ropivacaine. A comparative study

et al. 2015

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“…Articaine can modify cardiac action potentials and ion currents at concentrations higher than the therapeutic range, but may be moderate even in the case of overdose 75. The effects of articaine and ropivacaine on the components of intracellular Ca 2+ handling, the cause of negative inotropic actions, were studied and compared in canine ventricular myocardium 76. Under conditions of normal application, both articaine and ropivacaine are free of cardiodepressant effects.…”

Section: Toxicity and Safetymentioning

confidence: 99%

Articaine: a review of its use for local and regional anesthesia

Snoeck¹

2012

LRA

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Articaine is an intermediate-potency, short-acting amide local anesthetic with a fast metabolism due to an ester group in its structure. It is effective with local infiltration or peripheral nerve block in dentistry, when administered as a spinal, epidural, ocular, or regional nerve block, or when injected intravenously for regional anesthesia. In comparative trials, its clinical effects were not generally significantly different from those of other short-acting local anesthetics like lidocaine, prilocaine, and chloroprocaine, and there is no conclusive evidence demonstrating above-average neurotoxicity. Articaine proved to be suitable and safe for procedures requiring a short duration of action in which a fast onset of anesthesia is desired, eg, dental procedures and ambulatory spinal anesthesia, in normal and in special populations.

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“…end-product inhibition). LSR was obtained as described above from rabbit skeletal muscle and the protein concentration was 5.5 g/ml in each experiment [22]. Total hydrolytic activity was measured as the decrease of optical density at the NADH absorbance wavelength (340 nm) and expressed in micromoles of inorganic phosphate per milligrams of protein per minute (abbreviated as I.U.)…”

Section: Atpase Activity Measurementsmentioning

confidence: 99%

Bile acids activate ryanodine receptors in pancreatic acinar cells via a direct allosteric mechanism

et al. 2015

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a b s t r a c tThe earliest critical event of pancreatitis is a long lasting high amplitude rise of intracellular Ca 2+ concentration of the acinar cell, which can be triggered by high concentration of bile acids. Although, Ca 2+ -release through ryanodine receptors (RyR) is involved in the process, the significance and the exact mechanism of bile acid's action on RyR has not been fully elucidated yet. Therefore, we aimed to test with various techniques and aspects whether bile acids exert a direct effect on RyR and SERCA pump.Our data show that taurocholic acid (TCA)-induced Ca 2+ release in pancreatic acinar cells was significantly reduced by the RyR antagonist dantrolene. Further, we show that TCA enhanced RyR's 3 H-ryanodine binding and triggered robust Ca 2+ -release from RyR-enriched vesicles in the pathologically relevant concentration range. RyR single channel current analysis demonstrated that 200 M TCA induced a 5-fold increase in the channel's open probability and caused a significant lengthening of the mean open time. TCA also suppressed Ca 2+ -uptake rate and ATP-ase activity of SERCA-enriched vesicles, but interestingly, failed to decrease Ca 2+ elimination rate in intact cells. Overall, our results strongly suggest that TCA opens RyR by an allosteric mechanism, which contribute significantly to bile acid-induced pathologic Ca 2+ -leak from the endoplasmic reticulum in pancreatic acinar cells.

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Effects of articaine and ropivacaine on calcium handling and contractility in canine ventricular myocardium

Cited by 7 publications

References 38 publications

Myocardial contractility impairment with racemic bupivacaine, non-racemic bupivacaine and ropivacaine. A comparative study

Myocardial contractility impairment with racemic bupivacaine, non-racemic bupivacaine and ropivacaine. A comparative study

Articaine: a review of its use for local and regional anesthesia

Bile acids activate ryanodine receptors in pancreatic acinar cells via a direct allosteric mechanism

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