In real engineering applications, machine parts are rarely completely homogeneous; in most cases, there are at least some minor notch effects or even more extensive inhomogeneities, which cause critical local stress concentrations from which fatigue fractures develop. In the present research, a shift of the Coffin–Manson εa–N material curve in a structure with random porosity subjected to dynamic LCF loads was studied. This allows the rest of the fatigue life prediction process to remain the same as if it were a homogeneous material. Apart from the cyclic σ–ε curve, which is relatively easy to obtain experimentally, the εa–N curve is the second most important curve to describe the correlation between the fatigue life N and the strain level εa. Therefore, the correct shift of the εa–N curve of the homogeneous material to a position corresponding to the porous state of the material is crucial. We have found that the curve shift can be efficiently performed on the basis of numerical simulations of a combination of five porosity-specific geometric influences and the associated regression analysis. To model the modified synthetic εa–N curve, five geometric influences of porosity by X-ray or μ-CT analysis are quantified, and then the porosity-adjusted coefficients of the Coffin–Manson equation are calculated. The proposed approach has been successfully applied to standard specimens with different porosity topography.