Effects of Asian dust event particles on inflammation markers in peripheral blood and bronchoalveolar lavage in pulmonary hypertensive rats

Yu, Lei; Chan, Chang-Chuan; Wang, Peng Yau; Lee, Chung Te; Cheng, Tsun‐Jen

doi:10.1016/s0013-9351(03)00136-1

Cited by 121 publications

(73 citation statements)

References 17 publications

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“…17 These studies suggest that inhaled particles induce systemic oxidative stress, 18 inflammation, 19,20 autonomic dysfunction, including tachycardia, reductions in heart rate variability and hypertension, 18,[20][21][22] and hypercoagulability. 23,24 Therefore, the particulate matter contained in AD may stimulate plaque rupture according to these mechanisms, resulting in AMI.…”

Section: Discussionmentioning

confidence: 99%

Desert Dust Is a Risk Factor for the Incidence of Acute Myocardial Infarction in Western Japan

Matsukawa

Michikawa

Ueda

et al. 2014

Circ: Cardiovascular Quality and Outcomes

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Background-Recently, there has been increasing concern about adverse health effects of exposure to desert dust events.However, the association between dust and the incidence of ischemic heart diseases is unknown. The aim of the present study was to elucidate whether Asian dust (AD), a windblown sand dust originating from mineral soil in China and Mongolia, is associated with the incidence of acute myocardial infarction (AMI). Methods and Results-We investigated the data regarding hospitalization because of AMI among 3068 consecutive patients from 4 AMI centers in Fukuoka, Japan, and data for AD from April 2003 to December 2010. We applied a time-stratified case-crossover design to examine the association between AD and the incidence of AMI. Using a conditional logistic regression analysis, we estimated the odds ratios of AMI associated with AD after controlling for ambient temperature and relative humidity. The occurrence of AD events 0 to 4 days before the day of admission was significantly associated with the incidence of AMI. In particular, the occurrence of AD 4 days before admission was significantly associated with the onset of AMI. Conclusions-These data suggest that exposure to AD a few days before symptom onset is associated with the incidence of AMI. (Circ Cardiovasc Qual Outcomes. 2014;7:743-748.)

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Section: Discussionmentioning

confidence: 99%

Desert Dust Is a Risk Factor for the Incidence of Acute Myocardial Infarction in Western Japan

Matsukawa

Michikawa

Ueda

et al. 2014

Circ: Cardiovascular Quality and Outcomes

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“…This mechanism stimulates lymphocytes, dendritic cells, and granulocytes, including the recruitment of neutrophils, resulting in acute inflammation. Pathologically for pneumonia, desert dust particles enhance the neutrophil number dose-dependently, as well as the expression of cytokines (IL-1β, IL-6, IL-8, IL-12, IFN-γ, TNF-α) and chemokines (KC, MCP-1, MCP-3, MIP-1α) in bronchoalveolar lavage fluid [138,[145][146][147][148]. These results suggest that the exacerbation of pneumonia by desert dust was due to the enhanced production of pro-inflammatory mediators via activation of TLR2 and NALP3 inflammasome pathways in alveolar macrophages [149].…”

Section: Pathogeny Of Desert Dust On Respiratory Diseasesmentioning

confidence: 99%

A Systematic Review of Global Desert Dust and Associated Human Health Effects

et al. 2016

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Dust storms and sandy dust events originating in arid and semi-arid areas can transport particulate material, pollutants, and potential transport long distances from their sources. Exposure to desert dust particles is generally acknowledged to endanger human health. However, most studies have examined anthropogenic particulate sources, with few studies considering contributions from natural desert dust. A systematic literature review was undertaken using the ISI Web of Knowledge and PubMed databases with the objective of identifying all studies presenting results on the potential health impact from desert dust particles across the world. This review reveals an imbalance between the areas most exposed to dust and the areas most studied in terms of health effects. Among the human health effects of dust storms are mortality and morbidity, arising from respiratory system, circulatory system, and other diseases. We summarize the quantitative results of current scientific health research and possible pathological mechanisms, and describe some of the many challenges related to understanding health effects from exposures to desert dust particles. Overall, for respiratory and circulatory mortality, both positive and negative associations have been reported for PM 10 of desert dust, but only a positive relationship was reported between PM 2.5-10 and mortality, and a positive relationship was also reported between PM 2.5 and human mortality. Future pathological studies should continue to focus on those mechanisms causing the most harmful effect of desert dust on respiratory and cardiovascular diseases. More attention should also be paid to the association between desert dust and the morbidity of other diseases, such as those affecting the reproductive system and nervous system.

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“…Amorphous and crystalline silica (SiO 2 ) [31][32][33][34][35][36], as well as ASD [9,10,[37][38][39][40] have been reported to cause inflammatory responses and damage with the release of inflammatory cytokines including IL-6 and TNF and with the generation of reactive oxygen species (ROS) in the lungs of experimental animals. Si was the major inorganic chemical element in the ASD tested in this study, which was derived from quartz and feldspar [28].…”

Section: Discussionmentioning

confidence: 99%

Pathological study of pulmonary toxicity induced by intratracheally instilled Asian sand dust (Kosa): Effects of lowered serum zinc level on the toxicity

Shimada

Miyake

Kenmotsu

et al. 2015

Folia Histochem Cytobiol.

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Introduction. We have previously reported that Asian sand dust (ASD) induced acute and chronic inflammatory changes in the lung of mice. Zinc (Zn) is reported to influence inflammation and wound healing. The purpose of the study was to assess the effects of lowered serum Zn levels on the lung toxicity induced by ASD. Material and methods. Mice that were fed diets containing normal (group 1) or low (group 2) content of Zn for 8 weeks were intratracheally instilled with 3.0 mg of ASD, followed by sacrifice at 24 hours, 2 weeks, and 1, 2 and 3 months after instillation. Paraffin sections of lung tissues were stained by hematoxylin and eosin and by immunohistochemistry to detect tumor necrosis factor (TNF) and interleukin (IL)-1b as well as inflammasome (NALP3), autophagy (LC-3) and lysosome (LAMP-1) markers. Selected samples of lung tissue were examined by electron microscopy. Results. Following histological examination of the lung, similar patterns of inflammatory changes were observed in mice with normal and low serum Zn concentrations; however, they were more prominent and persistent in mice with low serum Zn level. These changes were both purulent (acute) and pyogranulomatous (chronic) in nature. In the lung lesions of group 2 mice the changes within the cytoplasmic vacuoles of enlarged ASD-containing macrophages (Mo) were clearly visible. The macrophages expressed TNF and IL-1b, and semi-quantitative analysis revealed a larger number of TNF-positive Mo in mice with normal level of serum Zn and a larger number of IL-1b-positive Mo in mice with low level of serum Zn. Decreased positive LC-3 staining and dilated lysosomes containing ASD particles were observed in the cytoplasm of Mo in mice with low serum Zn concentration. Conclusions. These findings suggest that low serum zinc concentration may induce the modulation of cytokine expression and lysosomal malfunction by phagocytotic and/or autophagic mechanisms, and may result in interstitial pyogranulomatous inflammation in the lungs of mice treated with ASD.

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Effects of Asian dust event particles on inflammation markers in peripheral blood and bronchoalveolar lavage in pulmonary hypertensive rats

Cited by 121 publications

References 17 publications

Desert Dust Is a Risk Factor for the Incidence of Acute Myocardial Infarction in Western Japan

Desert Dust Is a Risk Factor for the Incidence of Acute Myocardial Infarction in Western Japan

A Systematic Review of Global Desert Dust and Associated Human Health Effects

Pathological study of pulmonary toxicity induced by intratracheally instilled Asian sand dust (Kosa): Effects of lowered serum zinc level on the toxicity

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