Wearable health monitoring smart systems based on flexible metal films are considered to be the next generation of devices for remote medical practice. However, cracks on the metallic surface of the films and difficulty in repeatability are the key issues that restrict the application of such wearable strain sensors. In this work, a flexible wearable strain sensor with high sensitivity and good repeatability was fabricated based on a patterned metal/polymer composite material fabricated through nanoimprint lithography. The mechanical properties were measured through cyclic tension and bending loading. The sensor exhibited a small ΔR/R0 error line for multiple test pieces, indicating the good mechanical stability and repeatability of the fabricated device. Moreover, the sensor possesses high sensitivity with gauge factors of 10 for strain less than 50% and 40 for strain from 50% to 70%. Various activities were successfully detected in real-time, such as swallowing, closing/opening of the mouth, and multi-angle bending of elbow, which illustrates the proposed sensor’s potential as a wearable device for the human body.