Effects of Astaxanthin in Obese Mice Fed a High-Fat Diet

Ikeuchi, Mayumi; Koyama, Tomoyuki; Takahashi, Jun; Yazawa, Kazunaga

doi:10.1271/bbb.60521

Cited by 188 publications

(122 citation statements)

References 17 publications

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“…Diet-induced obesity (DIO) models have been well established, and widely used to find effective functional foods for anti-obesity. In recent studies, many observations have been reported concerning the ingestion of certain functional foods or their components decreasing the accumulation of body fat and inhibiting the elevation of body weight (23)(24)(25)(26)(27).…”

Section: Discussionmentioning

confidence: 99%

Administration of Dried Aloe vera Gel Powder Reduced Body Fat Mass in Diet-Induced Obesity (DIO) Rats

Misawa

Tanaka

Nabeshima

et al. 2012

J Nutr Sci Vitaminol

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SummaryThe aim of the present study was to investigate the anti-obesity effects of Aloe vera gel administration in male Sprague-Dawley (SD) rats with diet-induced obesity (DIO). SD rats at 7 wk of age were fed either a standard diet (10 kcal% fat) (StdD) or high-fat (60 kcal% fat) diet (HFD) during the experimental period. Four weeks after of HFD-feeding, DIO rats (11 wk of age) were orally administered with two doses of Aloe vera gel powder (20 and 200 mg/kg/d) for 90 d. Body weights (g) and body fat (%) of HFD fed rats were significantly higher than those of StdD-fed rats. Although a modest decrease of body weight (g) was observed with the administration of dried Aloe vera gel powder, both subcutaneous and visceral fat weight (g) and body fat (%) were reduced significantly in Aloe vera gel-treated rats. Serum lipid parameters elevated by HFD were also improved by the Aloe vera gel treatment. The oxygen consumption (VO 2 ), an index of energy expenditure, was decreased in HFD-fed rats compared with that in StdD-fed rats. Administration of Aloe vera gel reversed the change in VO 2 in the HFD-fed rats. These results suggest that intake of Aloe vera gel reduced body fat accumulation, in part, by stimulation of energy expenditure. Aloe vera gel might be beneficial for the prevention and improvement of diet-induced obesity.

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Section: Discussionmentioning

confidence: 99%

Administration of Dried Aloe vera Gel Powder Reduced Body Fat Mass in Diet-Induced Obesity (DIO) Rats

Misawa

Tanaka

Nabeshima

et al. 2012

J Nutr Sci Vitaminol

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“…Ikeuchi et al 8 studied the effect of 30mg/kg H. pluvialis astaxanthin in obese rats fed a high-fat diet. The results showed that astaxanthin inhibited weight gain, reduced liver weight, hepatic triglycerides as well as triglycerides and plasma cholesterol.…”

Section: Astaxanthin and Chronic Diseasesmentioning

confidence: 99%

“…The presence of hydroxyl and carbonyl functional groups in ketocarotenoids, like astaxanthin, makes them excellent antioxidants 5,6 . The high antioxidant power of astaxanthin has shown beneficial effects on various diseases related to oxidative damage, such as hypertension 7 , obesity 8 , macular degeneration 9 and cancer 10,11 .…”

Section: Introductionmentioning

confidence: 99%

Astaxanthin: structural and functional aspects

Seabra

Pedrosa

2010

Rev. Nutr.

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1 Article based on L.M.J. SEABRA' s thesis project entitled "Litopenaeus vannamei shrimp: components of nutritional importance in meat and processing waste. A B S T R A C TAstaxanthin, a carotenoid belonging to the xanthophyll class, has stirred great interest due to its antioxidant capacity and its possible role in reducing the risk of some diseases. Astaxanthin occurs naturally in microalgae, such as Haematococcus pluvialis and the yeast Phaffia rhodozyma, and has also been considered to be the major carotenoid in salmon and crustaceans. Shrimp processing waste, which is generally discarded, is also an important source of astaxanthin. The antioxidant activity of astaxanthin has been observed to modulate biological functions related to lipid peroxidation, having beneficial effects on chronic diseases such as cardiovascular disease, macular degeneration and cancer. Researches have shown that both astaxanthin obtained from natural sources and its synthetic counterpart produce satisfactory effects, but studies in humans are limited to natural sources. There is no established nutritional recommendation regarding astaxanthin daily intake but most studies reported beneficial results from a daily intake of 4mg. Thus, this review discusses some aspects of the carotenoid astaxanthin, highlighting its chemical structure and antioxidant activity, and some studies that report its use in humans.Indexing terms: Antioxidants. Astaxanthin. Carotenoids. Chronic diseases. R E S U M O

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“…The anti-obesity effect of WEH was evaluated using obese mice that were fed a HFD with or without WEH for 11 wk. Female mice (3 wk old), but not male mice (6 wk old), were used in the experiment because it was easier to induce obesity in female mice by the HFD than in male mice (data not shown), and female mice (3-4 wk old) have been used in anti-obesity tests in previous studies (23,37,38). While there was hardly any difference in food intake between the HFD and WEH groups, the body-weight gain in the WEH groups was significantly lower than that in the HFD group (Fig.…”

Section: 29)mentioning

confidence: 99%

Water Extract of Houttuynia cordata Thunb. Leaves Exerts Anti-Obesity Effects by Inhibiting Fatty Acid and Glycerol Absorption

Miyata

Koyama

Yazawa

2010

J Nutr Sci Vitaminol

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Summary Houttuynia cordata Thunb. is used in folk medicine for diuresis and detoxification. However, it has not yet been reported to have an anti-obesity effect. We found that the water extract of H. cordata leaves (WEH) inhibited the corn oil-induced increase in plasma triglyceride levels in mice. WEH also inhibited the oleic acid-and glycerol-induced increase in the levels of plasma nonesterified fatty acids and glycerol, respectively. Moreover, WEH had anti-obesity effects in mice with high-fat-diet-induced obesity. Therefore, WEH may be able to prevent or reduce obesity induced by a high-fat diet. Key Words Houttuynia cordata Thunb., anti-obesity, fatty acid, glycerol, triglycerideObesity is an abnormal condition in which excessive triglycerides (TGs) accumulate in the adipose tissue. In Japan, the number of obese people older than 20 y (body mass index, Ͼ 25) has been increasing yearly because of inadequate exercise, westernization of diet, and irregular eating habits. According to a national health and nourishment investigation conducted by the Ministry of Health, Labour and Welfare in 2007, about 1 of 4 Japanese adults is obese. Obesity is the most important risk factor for lifestyle-related diseases such as hypertension, type 2 diabetes and hyperlipemia ( 1-4 ). In particular, obesity causes an imbalance in the level of adipocytokines secreted by adipocytes, such as leptin, adiponectin, resistin, and plasminogen activator inhibitor-1, due to the excessive accumulation of visceral fat, and can cause metabolic syndrome ( 5 , 6 ). Furthermore, when symptoms worsen, metabolic syndrome can develop into atherosclerotic disease, which is associated with a very high mortality rate ( 7 , 8 ). Therefore, it is important to prevent or reduce obesity to achieve a better health-related quality of life.Houttuynia cordata Thunb. (Saururaceae), which is called dokudami in Japanese, is widely distributed in eastern Asia, including China, Korea, and Japan, and is used in folk medicine for diuresis and detoxification. It contains many flavonoids (quercitrin, isoquercitrin, rutin, etc.), alkaloids (aristolactam B, norcepharadione B, splendidine, etc.), and volatile components of essential oils (methyl-n -nonyl ketone, lauraldehyde, ␤ -myrcene, etc.) ( 9-11 ). Thus far, the extracts and components of H. cordata have been demonstrated to exhibit antioxidative, antiviral, antibacterial, antihypertensive and anti-inflammatory effects ( 12-17 ). However, these extracts have not yet been reported to have anti-obesity effects. Therefore, in this study we examined the antiobesity action of H. cordata . MATERIALS AND METHODS Materials. The Free Glycerol Determination Kit andLipase Kit S were purchased from Sigma-Aldrich Co. (St. Louis, MO, USA) and DS Pharma Biomedical Co. Ltd. (Osaka, Japan), respectively. Porcine pancreatic lipase was obtained from ICN Biomedicals (Aurora, OH, USA). The mouse diet was purchased from Oriental Yeast Co., Ltd. (Tokyo, Japan). The other materials were purchased from Wako Pure Chemical Industries, Ltd....

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Effects of Astaxanthin in Obese Mice Fed a High-Fat Diet

Cited by 188 publications

References 17 publications

Administration of Dried Aloe vera Gel Powder Reduced Body Fat Mass in Diet-Induced Obesity (DIO) Rats

Administration of Dried Aloe vera Gel Powder Reduced Body Fat Mass in Diet-Induced Obesity (DIO) Rats

Astaxanthin: structural and functional aspects

Water Extract of Houttuynia cordata Thunb. Leaves Exerts Anti-Obesity Effects by Inhibiting Fatty Acid and Glycerol Absorption

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