Effects of astragalus injection on the TGFβ/Smad pathway in the kidney in type 2 diabetic mice

Nie, Yanna; Li, Shuyu; Yi, Yue-e; Su, Weilian; Chai, Xiangping; Jia, Dexian; Wang, Qian

doi:10.1186/1472-6882-14-148

Cited by 25 publications

(24 citation statements)

References 33 publications

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“…Asperulosidic acid, a bioactive iridoid glycoside, can also exert renal protective effects by inactivating both TGF-β/Smad and NF-κB signaling pathways (Xianyuan et al, 2019). Similar therapeutic effects are also found in other studies with herbal medicines (Nie et al, 2014;Wan et al, 2014;Zhao et al, 2016). Targeting Smad3-dependent non-coding RNAs could be another therapeutic approach to treat renal fibrosis and inflammation (Figure 4c).…”

Section: Treatment Of Ckd By Targeting Downstream Tgf-β/smad Signalinsupporting

confidence: 62%

Diverse Role of TGF-β in Kidney Disease

Liu

Huang

et al. 2020

Front. Cell Dev. Biol.

182

132

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Section: Treatment Of Ckd By Targeting Downstream Tgf-β/smad Signalinsupporting

confidence: 62%

Diverse Role of TGF-β in Kidney Disease

Liu

Huang

et al. 2020

Front. Cell Dev. Biol.

182

132

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“…Bge.) is capable of reducing albuminuria, improving renal function, and ameliorating pathological changes [ 29 , 30 ]. Burning bush ( E .…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Tangshen Formula on Patients with Type 2 Diabetic Kidney Disease: A Multicenter Double-Blinded Randomized Placebo-Controlled Trial

et al. 2015

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BackgroundPersons with diabetes are at high risk of developing diabetic kidney disease (DKD), which is associated with high morbidity and mortality. Current drug therapies for DKD, such as angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), are not entirely satisfactory. This study aimed to evaluate the additional benefit and safety of the Chinese herbal granule Tangshen Formula (TSF) in treating DKD.MethodsThe study was designed as a six-center randomized, double-blind, placebo-controlled trial. From April 2007 through December 2009, 180 patients with DKD were enrolled. In addition to conventional treatment with ACEIs or ARBs, 122 participants were randomly assigned to receive TSF and 58 participants to receive placebo for 24 weeks. Primary outcome was urinary protein level, measured by urinary albumin excretion rate (UAER) for participants with microalbuminuria, 24-hour urinary protein (24h UP) for participants with macroalbuminuria. Secondary outcomes included renal function, serum lipids, quality of life, symptoms, and adverse events.FindingsAfter 24 weeks of treatment, no statistically significant difference in UAER (TSF −19.53 μg/min compared with placebo −7.01 μg/min, with a mean difference of −12.52 μg/min; 95%CI, −68.67 to 43.63, P = 0.696) was found between TSF and placebo groups. However, TSF displayed a statistically significant decrease in 24h UP (TSF−0.21 g compared with placebo 0.36 g, with a mean difference of −0.57g; 95%CI, −1.05 to −0.09, P = 0.024). Estimated glomerular filtration rate (eGFR) was improved in both patients with microalbuminuria and macroalbuminuria, with a mean difference of 15.51 ml/min/1.73 m2 (95%CI, 3.71 to 27.31), 9.01 ml/min/1.73 m2 (95%CI, −0.10 to 18.13), respectively. Other secondary outcomes showed no statistically significant difference between groups or in the incidence of adverse events.ConclusionsBased on conventional treatments, TSF appears to provide additional benefits compared with placebo in decreasing proteinuria and improving eGFR in DKD patients with macroalbuminuria. Nevertheless, further study is needed to evaluate TSF treating patients with microalbuminuria.Trial RegistrationChinese Clinical Trial Registry ChiCTR-TRC-10000843

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“…Astragalus (Huang Qi in Chinese), also named as radix astragali, is a TCM from Mongolian milkvetch or membranaceus milkvetch. A meta-analysis comprising 25 studies showed that Astragalus injection had more therapeutic effect in DN patients such as decreasing BUN, Scr, and urine protein and improving Ccr and serum albumin level [ 63 ], and rebalancing TGF- β /Smad signaling could be a potential mechanism to prevent DN in KK-Ay mice [ 64 ]. Astragalus may protect diabetic rats kidney mediated by downregulation of Tie-2 [ 110 ], and radix astragali was reported to upregulate c-met expression in human kidney fibroblasts to delay the progression of DN [ 65 ].…”

Section: Applications Of Tcm In Dnmentioning

confidence: 99%

Review of Herbal Traditional Chinese Medicine for the Treatment of Diabetic Nephropathy

Sun

Cui

et al. 2016

Journal of Diabetes Research

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Diabetic nephropathy (DN) is the most serious chronic complications of diabetes; 20–40% of diabetic patients develop into end stage renal disease (ESRD). However, exact pathogenesis of DN is not fully clear and we have great difficulties in curing DN; poor treatment of DN led to high chances of mortality worldwide. A lot of western medicines such as ACEI and ARB have been demonstrated to protect renal function of DN but are not enough to delay or retard the progression of DN; therefore, exploring exact and feasible drug is current research hotspot in medicine. Traditional Chinese medicine (TCM) has been widely used to treat and control diabetes and its complications such as DN in a lot of scientific researches, which will give insights into the mechanism of DN, but they are not enough to reveal all the details. In this paper, we summarize the applications of herbal TCM preparations, single herbal TCM, and/or monomers from herbal TCM in the treatment of DN in the recent 10 years, depicting the renal protective effects and the corresponding mechanism, through which we shed light on the renal protective roles of TCM in DN with a particular focus on the molecular basis of the effect and provide a beneficial supplement to the drug therapy for DN.

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Effects of astragalus injection on the TGFβ/Smad pathway in the kidney in type 2 diabetic mice

Cited by 25 publications

References 33 publications

Diverse Role of TGF-β in Kidney Disease

Diverse Role of TGF-β in Kidney Disease

Efficacy and Safety of Tangshen Formula on Patients with Type 2 Diabetic Kidney Disease: A Multicenter Double-Blinded Randomized Placebo-Controlled Trial

Review of Herbal Traditional Chinese Medicine for the Treatment of Diabetic Nephropathy

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