Effects of asymptomatic cerebral artery stenosis of anterior circulation and establishment of collateral circulation on cognition

Zhang, N.; Xie, Binbin; Feng, Yuxue; Li, Qin; Li, Xiaofeng

doi:10.1016/j.clineuro.2023.107889

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…In a two-year follow-up study, the presence of robust collateral circulation in cases of severe middle cerebral artery stenosis correlated with a reduced risk of cognitive impairment, contrasting with patients exhibiting poor to moderate leptomeningeal collateral systems who experienced deterioration in cognitive domains [154]. This connection was confirmed by another study, analyzing the effect of cerebral artery stenosis of anterior circulation on cognition [155]. Furthermore, an association was found between poor collateralization within the CoW and early cognitive dysfunction after carotid endarterectomies.…”

Section: Effects Of the Cow On Cognitive Dysfunction In Patients With...mentioning

confidence: 70%

Non-Invasive Tools in Perioperative Stroke Risk Assessment for Asymptomatic Carotid Artery Stenosis with a Focus on the Circle of Willis

Lengyel,

Magyar-Stang,

Pál

et al. 2024

JCM

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This review aims to explore advancements in perioperative ischemic stroke risk estimation for asymptomatic patients with significant carotid artery stenosis, focusing on Circle of Willis (CoW) morphology based on the CTA or MR diagnostic imaging in the current preoperative diagnostic algorithm. Functional transcranial Doppler (fTCD), near-infrared spectroscopy (NIRS), and optical coherence tomography angiography (OCTA) are discussed in the context of evaluating cerebrovascular reserve capacity and collateral vascular systems, particularly the CoW. These non-invasive diagnostic tools provide additional valuable insights into the cerebral perfusion status. They support biomedical modeling as the gold standard for the prediction of the potential impact of carotid artery stenosis on the hemodynamic changes of cerebral perfusion. Intraoperative risk assessment strategies, including selective shunting, are explored with a focus on CoW variations and their implications for perioperative ischemic stroke and cognitive function decline. By synthesizing these insights, this review underscores the potential of non-invasive diagnostic methods to support clinical decision making and improve asymptomatic patient outcomes by reducing the risk of perioperative ischemic neurological events and preventing further cognitive decline.

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Section: Effects Of the Cow On Cognitive Dysfunction In Patients With...mentioning

confidence: 70%

Non-Invasive Tools in Perioperative Stroke Risk Assessment for Asymptomatic Carotid Artery Stenosis with a Focus on the Circle of Willis

Lengyel,

Magyar-Stang,

Pál

et al. 2024

JCM

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Effects of intracranial artery stenosis of anterior circulation on cognition—A CT perfusion‐based study

Yin,

Zhang,

et al. 2024

Brain and Behavior

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BackgroundIntracranial atherosclerotic stenosis (ICAS) is one of the most important independent risk factors for stroke that is closely related to the occurrence of cognitive impairment. The relationship between ICAS and vascular cognitive impairment (VCI) remains unclear. Cerebral hemodynamic changes are one of the main causes of cognitive impairment. Computed tomographic perfusion (CTP) imaging can quantitatively analyze cerebral blood perfusion and quantify cerebral hemodynamic changes. Previous research on the relationship between hypoperfusion induced by ICAS and cognitive impairment, as well as its underlying mechanisms, remains relatively insufficient. This study is dedicated to elucidating the characteristics and potential mechanisms of cognitive impairment in ICAS patients with abnormal perfusion, utilizing CTP imaging as our primary investigative tool.MethodsThis study recruited 82 patients who suffer from non‐disabling ischemic stroke (IS group) and 28 healthy controls. All participants underwent comprehensive neuropsychological assessments both collectively and individually, in addition to CTP imaging. Within the patient group, we further categorized individuals into two subgroups: the ischemic penumbra group (IP, N = 28) and the benign oligemia group (BO, N = 54), based on CTP parameters—Tmax. The correlations between cognitive function and abnormal perfusion were explored.ResultsThe cognitive function, including the overall cognitive, memory, attention, executive functions, and language, was significantly impaired in the IS group compared with that in the control group. Further, there are statistical differences in the stroop color–word test‐dot (Stroop‐D) and Montreal Cognitive Assessment (MoCA) sub‐items (memory + language) between the BO and IP groups. In the BO group, the score of Stroop‐D is lower, and the MoCA sub‐items are higher than the IP group. There is no correlation between CTP parameters and cognitive function.ConclusionCognitive function is significantly impaired in patients with ICAS, which is related to cerebral perfusion. Executive, memory, and language function were better preserved in ICAS patients without IP. Hence, this study posits that managing hypoperfusion induced by ICAS may play a pivotal role in the development of VCI.

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Association of hemoglobin with plasma neurofilament light and white matter hyperintensities in Alzheimer's disease continuum

Li,

Zhan,

Liao

et al. 2024

Heliyon

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Effects of asymptomatic cerebral artery stenosis of anterior circulation and establishment of collateral circulation on cognition

Cited by 3 publications

References 18 publications

Non-Invasive Tools in Perioperative Stroke Risk Assessment for Asymptomatic Carotid Artery Stenosis with a Focus on the Circle of Willis

Non-Invasive Tools in Perioperative Stroke Risk Assessment for Asymptomatic Carotid Artery Stenosis with a Focus on the Circle of Willis

Effects of intracranial artery stenosis of anterior circulation on cognition—A CT perfusion‐based study

Association of hemoglobin with plasma neurofilament light and white matter hyperintensities in Alzheimer's disease continuum

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