Effects of atorvastatin therapy on hypercholesterolemic rabbits with respect to oxidative stress, nitric oxide pathway and homocysteine

Bolayırlı, Murat; Aslan, Mine; Balcı, Huriye; Altuğ, Tuncay; Hacıbekiroğlu, Münire; Seven, Arzu

doi:10.1016/j.lfs.2007.04.027

Cited by 57 publications

(64 citation statements)

References 49 publications

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“…Decreases in PON1 activities before treatment may depend on these oxidative stresses. Previous studies (7,8) suggested that oxidative stress depresses PON1 activity with inadequate antioxidant capacity, *P < 0.05 vs. control, ***P < 0.001 vs. control, ##P < 0.01 vs. before treatment group. excess oxidative stress, and inflammatory response, as evident in hypercholesterolemic patients.…”

Section: Discussionmentioning

confidence: 92%

“…Homocysteine thiolactone, which is a both toxic and cytotoxic metabolic product of homocysteine, is detoxified by the homocysteine thiolactonase activity of PON1 (7). Hence, PON1 prevents protein homocysteinylation, the process involved in atherogenesis.…”

Section: Introductionmentioning

confidence: 99%

“…Some statins and their metabolites also act as free radical scavengers, reducing reactive oxygen species (ROS) formation (7). Statins increase serum PON1 activity, improve endothelial function, enhance the stability of atherosclerotic plaques, and suppress vascular inflammation (9).…”

Section: Introductionmentioning

confidence: 99%

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The effects of atorvastatin on antioxidant/antiinflammatory propertiesof HDLs in hypercholesterolemics

Çiftçi¹,

Ertorun²,

Akalın³

et al. 2015

Turk J Med Sci

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Background/aim: Hypercholesterolemia is characterized by changes in lipid profile, nitric oxide pathway, and oxidative stress markers, but functions of high-density lipoprotein (HDL) were not well established in hypercholesterolemic subjects treated with atorvastatin. In this study, we aimed to evaluate effects of atorvastatin treatment on functionality of HDL, oxidative stress, and endothelial functions in hypercholesterolemic subjects. Materials and methods:Thirty patients (20 females, 10 males) aged from 40 to 60 years and diagnosed as hypercholesterolemic were included. Patients were treated with 10 mg/day atorvastatin for 3 months. Markers of endothelial functions, namely asymmetric dimethylarginine (ADMA), homocysteine, and nitric oxide (NO), and markers of oxidative status, namely malondialdehyde (MDA), antioxidant potential (AOP), paraoxonase 1 (PON1), and arylesterase, were measured. Before and after atorvastatin treatment, glucose, lipid parameters, and antioxidant/antiinflammatory HDL levels were also measured.Results: ADMA and homocysteine levels were decreased whereas NO levels were increased with atorvastatin therapy. MDA levels were decreased but AOP, PON1, and arylesterase levels and antiinflammatory characteristics of HDLs were increased. Furthermore, lipid profiles of the patients improved with atorvastatin therapy. Conclusion:Hypercholesterolemia is a cause of oxidative stress, endothelial dysfunction, and proinflammatory HDL levels. Atorvastatin is a beneficial pharmacological modulator of impaired antiinflammatory HDL-C levels, endothelial functions, and oxidative status against atherosclerosis indicating pleiotropic effects of statins.

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The effects of atorvastatin on antioxidant/antiinflammatory propertiesof HDLs in hypercholesterolemics

Çiftçi¹,

Ertorun²,

Akalın³

et al. 2015

Turk J Med Sci

View full text Add to dashboard Cite

show abstract

“…In addition to these roles PON1 has also been shown to play a role in the metabolism of pharmaceutical drugs [18]. It was found that PON1 enzyme activity was increased significantly in rabbits that had been fed a hypercholesterolemic diet with four weeks of atorvastatin application [19]. In another study, patients with established cardiovascular disease with highdensity lipoprotein cholesterol were treated with rosuvastatin and this resulted in a significant increment of serum PON-1 activity with increasing dose although this was not observed with atorvastatin [17].…”

Section: Resultsmentioning

confidence: 99%

Differential effects of some antibiotics on paraoxonase enzyme activity on human hepatoma cells (HepG2) in vitro

Köçkar

Sinan

Yıldırım

et al. 2010

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…Consistently with our data, some studies reported that statins and the synthetic derivatives from natural phenolic antioxidants are effective not only in lowering lipid levels, but also in suppressing development of atherosclerotic lesion and oxidative stress in cholesterol dietinduced hypercholesterolemic rats and rabbits. [32][33][34] 3-Hydroxy-3-methyl-glutaryl (HMG)-CoA reductase inhibitors (statins) are potent inhibitors of cholesterol biosynthesis in the liver by blocking the conversion of HMG-CoA to mevalonate, the ratelimiting step in the mevalonate pathway. 13 Also, several studies have demonstrated that statins have pleiotropic effects such as the reduction of endothelial dysfunction, inhibition of inflammatory responses, stabilization of atherosclerotic plaques, and modulation of procoagulant activity and platelet function.…”

Section: Discussionmentioning

confidence: 99%

Lipid Lowering and Antioxidant Effects of Newly Synthesized 4-[(Butylsulfinyl)methyl]-1,2-benzenediol (SMBD) in Diet-induced Hypercholesterolemic Rabbits

Kim¹,

Noh²,

Kwon³

et al. 2010

Bulletin of the Korean Chemical Society

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We investigated the effects of newly synthesized 4-[(butylsulfinyl)methyl]-1,2-benzenediol (SMBD) on the prevention of atherosclerosis in hypercholesterolemic rabbits. SMBD exhibited stronger inhibition of Cu 2+ -induced low-density lipoprotein oxidation than that of ascorbic acid or simvastatin. Three-month-old rabbits were fed an atherogenic diet containing 0.5% cholesterol and 10% coconut oil, while other two groups were given an atherogenic diet with intravenous injection of either simvastatin or SMBD (0.33 mg/kg/day) for 4 weeks. The concentrations of plasma cholesterol and thiobarbituric acid reactive substances were significantly decreased in SMBD groups, compared to the control group. Also, aortic lipid level in the SMBD group significantly lower than that in the control group. Furthermore, compared with the control group, the SMBD group significantly inhibited the increase of aortic intimal thickness by 36% via reducing of aortic reactive oxygen species and cyclooxygenase-2 protein levels. We conclude that raised antioxidant effect of SMBD results in significant prevention against hypercholesterolemia.

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Effects of atorvastatin therapy on hypercholesterolemic rabbits with respect to oxidative stress, nitric oxide pathway and homocysteine

Cited by 57 publications

References 49 publications

The effects of atorvastatin on antioxidant/antiinflammatory propertiesof HDLs in hypercholesterolemics

The effects of atorvastatin on antioxidant/antiinflammatory propertiesof HDLs in hypercholesterolemics

Differential effects of some antibiotics on paraoxonase enzyme activity on human hepatoma cells (HepG2) in vitro

Lipid Lowering and Antioxidant Effects of Newly Synthesized 4-[(Butylsulfinyl)methyl]-1,2-benzenediol (SMBD) in Diet-induced Hypercholesterolemic Rabbits

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