Effects of atrial natriuretic peptide at a low dose on water and electrolyte metabolism during general anesthesia

Renal effects of intraoperative atrial natriuretic peptide

“…Because inflammatory cytokines and reactive oxygen species are involved in the pathogenesis of acute tubular necrosis, antioxidants and antiinflammatory agents such as acetylcysteine have been studied. A recent addition to the various pharmacological agents that have been used to optimize renal perfusion and tubular function is the synthetic form of atrial natriuretic peptide (ANP), the subject of the paper by Koda et al [2] which appears in this issue of the Journal of Clinical Anesthesia.…”

“…Aware of the diuretic effect of ANP, Koda et al [2] investigated whether it might play a role in manipulating perioperative renal function. They studied the effects of a low therapeutic intravenous infusion of ANP in the perioperative period.…”

“…Koda et al [2] examined the effect of a low-dose ANP infusion on hormonal, renal, and hemodynamic function. They assigned patients scheduled for gastrectomy to receive prospectively either a low-dose ANP infusion or saline.…”