Effects of Atropine and Pirenzepine on Heart Rate Turbulence

Vukajlović, Dejan; Guettler, Norbert; Mirić, Milutin; Pitschner, Heinz F.

doi:10.1111/j.1542-474x.2006.00079.x

Cited by 13 publications

(8 citation statements)

References 10 publications

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“…The effects of muscarinic receptor blockade with atropine were also investigated (2,36,86). In patients without structural heart disease, atropine caused a significant TS decrease and a significant TO increase.…”

Section: Modifications Of Hrt By Specific Interventionsmentioning

confidence: 99%

Heart Rate Turbulence: Standards of Measurement, Physiological Interpretation, and Clinical Use

Bauer¹,

Malík

Schmidt³

et al. 2008

Journal of the American College of Cardiology

397

432

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This consensus statement has been compiled on behalf of the International Society for Holter and Noninvasive Electrophysiology. It reviews the topic of heart rate turbulence (HRT) and concentrates on technologies for measurement, physiologic background and interpretation, and clinical use of HRT. It also lists suggestions for future research. The phenomenon of HRT refers to sinus rhythm cycle-length perturbations after isolated premature ventricular complexes. The physiologic pattern of HRT consists of brief heart rate acceleration (quantified by the so-called turbulence onset) followed by more gradual heart rate deceleration (quantified by the so-called turbulence slope) before the rate returns to a pre-ectopic level. Available physiologic investigations confirm that the initial heart rate acceleration is triggered by transient vagal inhibition in response to the missed baroreflex afferent input caused by hemodynamically inefficient ventricular contraction. A sympathetically mediated overshoot of arterial pressure is responsible for the subsequent heart rate deceleration through vagal recruitment. Hence, the HRT pattern is blunted in patients with reduced baroreflex. The HRT pattern is influenced by a number of factors, provocations, treatments, and pathologies reviewed in this consensus. As HRT measurement provides an indirect assessment of baroreflex, it is useful in those clinical situations that benefit from baroreflex evaluation. The HRT evaluation has thus been found appropriate in risk stratification after acute myocardial infarction, risk prediction, and monitoring of disease progression in heart failure, as well as in several other pathologies.

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Section: Modifications Of Hrt By Specific Interventionsmentioning

confidence: 99%

Heart Rate Turbulence: Standards of Measurement, Physiological Interpretation, and Clinical Use

Bauer¹,

Malík

Schmidt³

et al. 2008

Journal of the American College of Cardiology

397

432

View full text Add to dashboard Cite

show abstract

“…First, HRV indicates variability of the R-R interval, not an index for determination of cardiac autonomic nervous activity quantitatively. Parasympathetic blockade by using atropine is a standard method to evaluate parasympathetic activity (Berntson et al, 1997;Vukajlovic et al, 2006). However, this study does not clarify the influence of medical agents.…”

Section: Methodological Limitationsmentioning

confidence: 91%

Cardiac Autonomic Control Immediately after Exercise in Female Distance Runners

Suzuki

Sumi

Matsubara³

2008

J Physiol Anthropol

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The purpose of this study was to examine the timing of recovery of the high-frequency (HF) component of heart rate variability (HRV) after exercise in female distance runners using frequency analysis of HRV. Twenty-two female young (nϭ11; YG) and middle-aged (nϭ11; MG) distance runners participated in this study. The two groups performed incremental cycle exercise with progressive intensity until exhaustion. The R-R intervals were processed by the maximum entropy method for determination of HF power on successive 7-second segments of 70 seconds of the recovery period. In the YG, the HF power of the second 7-sec segment showed significantly higher values than the 7 sec before cessation of exercise (pϽ0.005), whereas the MG exhibited significantly higher values in the third segment (pϽ0.005). The YG indicated significantly higher HF power than the MG in the fifth segment (pϽ0.0045). These findings suggested the occurrence of parasympathetic reactivation at an earlier period compared to the previous findings. Multiple influences of various factors including the subjects' characteristics to HF recovery were suggested. However, the detection of the timing of HF recovery despite the duration of sharp change in HR indicated that HRV was an effective evaluation technique for determination of autonomic control immediately after exercise.

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“…They are not only used for the management of disease conditions but also for maintenance of proper health [27]. The past decade revealed that plant-based herbal remedies are the emerging choice for the treatment of various ailments [28]. Most of the widely used modern medicines for the treatment of cardiovascular abnormalities have side effects and there is dire need to search for alternative therapies with fewer or no side effects.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Property of Total Saponins and Tannins of Dialium guineense Stem Bark in Rats Hearts Exposed to CCl4

OD¹,

HE²

2022

J Clin Epid Toxic

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The aim of this study was to investigate the antioxidant property of total saponins and tannins of Dialium guineense stem bark in rats hearts exposed to carbon tetrachloride (CCl4 ). A total of twenty-five (25) adult male Wistar rats, which weighed between 170 and 190 g (mean weight = 180 ± 10 g) were randomly assigned to five groups (5 rats per group): normal control, CCl4 control, silymarin, total saponins and total tannins groups. With the exception of normal control group, the rats were exposed to CCl4 (single oral dose of 1.0 mL/kg body weight, bwt). Rats in the silymarin group were administered 100 mg silymarin/kg bwt (standard cardioprotective drug), while those in the two treatment groups received 150 mg/kg bwt of total saponins or tannins orally for a period of 28 days. Activities of antioxidant enzymes such as catalase, superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GR) were evaluated in heart homogenate. The results showed that there were no significant differences in the concentrations of cardiac total protein (TP) among the groups (p > 0.05). The activities of the antioxidant enzymes and level of reduced glutathione (GSH) were significantly lower in CCl4 control group than in normal control group, but they were increased by total saponins/tannins treatment (p < 0.05). However, the level of cardiac malondialdehyde (MDA) elevated by CCl4 intoxication was markedly reduced after treatment (p < 0.05). These results indicate that total saponins and tannins of D. guineense stem bark may enhance antioxidant defense in rats hearts exposed to CCl4.

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Effects of Atropine and Pirenzepine on Heart Rate Turbulence

Abstract: A conclusion could be drawn that vagomymetic manipulation with intravenous pirenzepine increases HRT; vagal blockade with atropine decreases HRT. This finding suggests that a normal vagal innervation of heart is a prerequisite for the phenomenon of HRT.

Cited by 13 publications

References 10 publications

Heart Rate Turbulence: Standards of Measurement, Physiological Interpretation, and Clinical Use

Heart Rate Turbulence: Standards of Measurement, Physiological Interpretation, and Clinical Use

Cardiac Autonomic Control Immediately after Exercise in Female Distance Runners

Antioxidant Property of Total Saponins and Tannins of Dialium guineense Stem Bark in Rats Hearts Exposed to CCl4

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