Effects of Atypical Neurotoxins on the Developing Fetal Brain

Abstract

The brain is not only a control center of the body but also a part of the way that the body can communicate with external environments. The spatial and temporal events of brain development are well-defined. These processes are sequentially regulated by intrinsic and external factors, such as gene. Disruption of these steps results in malformation and malfunction of the brain. Neurotoxin may affect our developing nervous system as a kind of endogenous and exogenous factor. For classical neurotoxins, such as heavy metals, snake venom, and bacterial toxins, the underlying toxin-mediated physiological pathways are relatively clear, and their antidotes are usually available. However, for atypical neurotoxins, such as air pollutants, food additives, and manufactural compounds, their effects on the nervous system are ordinarily extended and not easy to detect. In addition, the corresponding mechanism is too complex to define. A single and effective antidote against these atypical neurotoxins is uncommon, so prevention is better than cure with this kind of toxin. This chapter starts with the introduction of endogenous and exogenous neurotoxins, how they affect nervous system and their potential antidotes, followed by the impact of atypical neurotoxins in fetal brain development and their possible preventative or therapeutic methods.

Combined Use of Probiotics and Vitamin D Against Neurotoxicity: Traditional Review

“…12 After these neurotoxins cross the blood-brain barrier and reach the brain, they cause brain damage, resulting in learning difficulties, motor coordination disorders, and the onset of diseases such as Alzheimer diseases. 4,13,14 Microbial neurotoxins (botulinum, tetanus toxin, and lipopolysaccharide) are mostly produced by bacteria. These substances, which stimulate the nervous system, prevent the deliver of neurotransmitters from synaptic vesicles and block communication between neurons.…”

“…Endogenous are made by the human body, while exogenous are toxins that enter the human body from the external environment. 4 Endogenous toxins are primarily aging and genetic factors, exogenous toxins are pesticides and heavy metals. [4][5][6] ENDOGENOuS NEuROTOxINS…”

“…4 Endogenous toxins are primarily aging and genetic factors, exogenous toxins are pesticides and heavy metals. [4][5][6] ENDOGENOuS NEuROTOxINS…”

Brain neural network, development, microbiome, microbial toxins and COVID-19

“…In addition to the microbiome, microbial secondary metabolites, such as microbial toxins, can affect the physiology and behavior of the neural network [15]. Occupational exposure, daily routine, food consumption cultures and environmental factors in many places of the world are effective in the formation of different human microbiota and total microbial toxins volume in different forms.…”