Effects of autologous concentrated growth factor on gingival thickness in periodontal accelerated osteogenic orthodontics: a 6-month randomized controlled trial

Qi, Lei; Ge, Weiwen; Cao, Ningning; Wang, Shoupeng; Qian, Yong; Wang, Xudong; Zhang, Lei

doi:10.1186/s12903-021-01967-5

Cited by 6 publications

(8 citation statements)

References 45 publications

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“…Several studies have reported a gain of keratinized gingiva through PAOO, however, few studies analyzed the changes of gingival thickness [ 5 ]. Our preliminary results showed that the mean gingival thickness before surgery was 0.91 ± 0.32 mm and 1.21 ± 0.38 mm at 6 months after PAOO, and thus detected a mean gingival thickness gain of 0.30 ± 0.33 mm.…”

Section: Discussionmentioning

confidence: 99%

“…However, few studies have focused on the changes of gingival thickness induced by PAOO [ 5 ]. Various methods have been attempted to measure the gingival thickness, including transgingival probing, evaluation of probe transparency through the tissues, ultrasonographic devices and more recently, cone beam computed tomography (CBCT), however, no one technique has been widely used because of invasiveness or the complexity of application [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Periodontal soft tissue increase induced by periodontally accelerated osteogenic orthodontics surgery

Han¹,

Miao²,

Liu³

et al. 2022

BMC Oral Health

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Objectives To quantitatively assess periodontal soft tissue changes, including gingival thickness and keratinized gingiva width after periodontally accelerated osteogenic orthodontics (PAOO) surgery by digital measurements. Methods This study enrolled 15 maxillaries with 89 anterior teeth and 16 mandibles with 94 anterior teeth from Chinese adult patients with skeletal Angle Class III malocclusion for whom PAOO surgery was proposed during orthodontic treatment. Intraoral scanning and cone beam computed tomography (CBCT) examinations were performed before PAOO surgery and 6 months after the surgery. Keratinized gingiva width was measured on the digital model acquired by intraoral scanning. The gingival thickness was measured using a digital three-dimensional (3D) model based on the combination of digital intraoral scanning and CBCT data. Results The mean gingival thickness before surgery was 0.91 ± 0.32 mm and 1.21 ± 0.38 mm at 6-month after PAOO. Patients showed periodontal soft tissue increase with a mean gingival tissue gain of 0.30 ± 0.33 mm. At 1 mm, 2 and 3 mm apical to cemento-enamel junction (CEJ) levels, the gingival thickness increase of the mandible was higher than that of the maxilla (0.38 ± 0.30 mm vs. 0.24 ± 0.31 mm, 0.43 ± 0.35 mm vs. 0.26 ± 0.41 mm, 0.36 ± 0.27 vs. 0.25 ± 0.32 mm, respectively, all P < 0.05). Moreover, the sites of gingival thickness ≤ 1 mm before surgery showed more tissue gain than the sites > 1 mm (0.36 ± 0.32 mm vs. 0.18 ± 0.31 mm, P < 0.001). The mean keratinized gingiva width at T0 was 3.88 ± 1.22 mm, and increased 1.05 ± 1.24 mm 6 months after PAOO surgery. Moreover, a digital 3D model for gingival thickness measurement based on the combination of digital intraoral scanning and CBCT displayed high reliability and accuracy with an intra-class correlation coefficient (ICC) of 0.897. Conclusion PAOO could improve an insufficient quantity of periodontal soft and hard tissues in patients with skeletal Angle Class III malocclusion, including the gingival thickness and keratinized gingiva width. A digital 3D model based on the combination of digital intraoral scanning and CBCT data could provide a new digital measurement of gingival thickness with high accuracy and reliability.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Periodontal soft tissue increase induced by periodontally accelerated osteogenic orthodontics surgery

Han¹,

Miao²,

Liu³

et al. 2022

BMC Oral Health

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“…CGF is not only a plasma extract, but also a repair biomaterial that contains concentrated growth factors and fibrin, with the unique property of improving and enhancing tissue regeneration. 16 In this study, the clinical efficacy of the observation group was significantly higher than that of the control group, indicating a high efficacy of porcine collagen membrane + artificial bovine bone granules guided tissue regeneration combined with autologous CGF in the treatment of severe periodontitis bone defects, which is conducive to the rapid recovery of patients after surgery. This may be due to the fact that autologous CGF is derived from the patient's own venous blood.…”

Section: Discussionmentioning

confidence: 58%

Clinical observation of Porcine Collagen Membrane + artificial Bovine Bone Granules Guided tissue regeneration combined with Autologous CGF in the treatment of severe periodontitis bone defect

Cheng¹,

Cheng

Kong³

et al. 2023

Pak J Med Sci

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Objective: To investigate and analyze the clinical observation of porcine collagen membrane + artificial bovine bone granules guided tissue regeneration (GTR) combined with autologous concentration of growth factors (CGF) in the treatment of severe periodontitis bone defect. Methods: A total of 94 patients with severe periodontitis bone defects admitted to Shanxi Bethune Hospital from January 2019 to January 2022 were included. They were divided into two groups by simple randomization method. Patients in the control group were treated with porcine collagen membrane + artificial bovine bone granules GTR, while those in the observation group were treated with autologous CGF on the basis of the control group. Before and after treatment, periodontal clinical indicators [sulcus bleeding index (SBI), gingival retreat index (GR), probing depth (PD), clinical attachment loss (CAL), alveolar bone height (AH)] and bone resorption markers [Osteoprotegerin (OPG), bone gla protein (BGP), Type-1 collagen N-terminal peptide (NTX)] were compared between the two groups, and the incidence of postoperative complications in the two groups was recorded. Results: The total efficacy of observation group was significantly higher than that of control group (p<0.05). Three months after surgery, the observation group had lower levels of SBI, PD, CAL and NTX while higher levels of GR, AH, OPG and BGP than the control group (p<0.05). There was no significant difference in complication rate between the two groups (p>0.05). Conclusion: Porcine collagen membrane + artificial bovine bone granules GTR combined with autologous CGF boasts various benefits in the treatment of severe periodontitis bone defects, such as improvement of clinical outcomes, amelioration of periodontal tissue and inhibition of bone resorption. doi: https://doi.org/10.12669/pjms.39.3.6899 How to cite this: Cheng J, Cheng L, Kong LW, Qiu W, Zhuang R. Clinical observation of Porcine Collagen Membrane + artificial Bovine Bone Granules Guided tissue regeneration combined with Autologous CGF in the treatment of severe periodontitis bone defect. Pak J Med Sci. 2023;39(3):710-714. doi: https://doi.org/10.12669/pjms.39.3.6899 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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“…Furthermore, in addition to the treatment of gingival recession, one study [ 63 ] evaluated the effects of CGF on gingival thickness in patients with thin gingival phenotype undergoing periodontal accelerated osteogenic orthodontics (PAOO). The result of a parallel design RCT by Qi et al [ 63 ], involving 240 anterior mandibular teeth, suggested that the use of CGF membrane in PAOO for patients with thin gingival phenotype could significantly increase gingival thickness compared with PAOO + collagen membrane.…”

Section: Resultsmentioning

confidence: 99%

Efficacy of concentrated growth factor (CGF) in the surgical treatment of oral diseases: a systematic review and meta-analysis

Chen,

Cheng,

Cai

et al. 2023

BMC Oral Health

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Background Concentrated growth factor (CGF), a new autologous platelet concentrate, has been widely investigated to the adjunctive treatment of oral diseases. This study aims to evaluate the efficacy of CGF in the surgical treatment of oral diseases. Methods MEDLINE, Web of Science, Scopus, Cochrane, and EMBASE databases were searched up to July 2023. Only randomized clinical trials were included. The methodologic quality was evaluated by the Cochrane Risk of Bias Tool. RevMan 5.4 software was used for data analysis. Results In the treatment of periodontal intrabony defects, bone graft combined with CGF was significantly superior to bone graft (P < 0.01), with mean intrabony defect depth reduction of 1.41 mm and mean clinical attachment level gain of 0.55 mm. In the regenerative surgery of furcation defects, the effect of CGF group was significantly better than control group (P < 0.0001), with mean probing depth reduction of 0.99 mm, vertical bone gain of 0.25 mm, and horizontal bone gain of 0.34 mm. CGF combined with coronally advanced flap (CAF) was more effective than CAF alone (mean keratinized tissue width increase of 0.41 mm, mean gingival thickness increase of 0.26 mm, P < 0.00001), but less effective than connective tissue graft (CTG) combined with CAF (mean root coverage difference of -15.1%, mean gingival thickness difference of -0.5 mm, P < 0.0001). In the alveolar ridge preservation, additional use of CGF reduced horizontal bone resorption by 1.41 mm and buccal vertical bone resorption by 1.01 mm compared to control group (P < 0.0001). The VAS score of CGF group was significantly lower than that of the control group at the 1st and 7th day after oral surgery (P < 0.0001). Conclusions CGF can exert a positive adjunctive effect for the regenerative surgery of periodontal intrabony defects, furcation defects, and alveolar ridge preservation procedure. CGF combined with CAF has a better therapeutic effect on gingival recession compared to CAF alone, although it is not as effective as CTG combined with CAF. CGF could promote postoperative healing and pain relief in oral surgery within a week. There is currently not enough evidence to support the clinical benefits of CGF in other oral surgeries.

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Effects of autologous concentrated growth factor on gingival thickness in periodontal accelerated osteogenic orthodontics: a 6-month randomized controlled trial

Cited by 6 publications

References 45 publications

Periodontal soft tissue increase induced by periodontally accelerated osteogenic orthodontics surgery

Periodontal soft tissue increase induced by periodontally accelerated osteogenic orthodontics surgery

Clinical observation of Porcine Collagen Membrane + artificial Bovine Bone Granules Guided tissue regeneration combined with Autologous CGF in the treatment of severe periodontitis bone defect

Efficacy of concentrated growth factor (CGF) in the surgical treatment of oral diseases: a systematic review and meta-analysis

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