Effects of Azelastin on Pruritus and Plasma Histamine Levels in Hemodialysis Patients

Matsui, Chieko; Ida, Mitsuru; Hamada, Masaaki; Morohashi, Masaaki; Hasegawa, Masato

doi:10.1111/j.1365-4362.1994.tb01025.x

Cited by 18 publications

(9 citation statements)

References 13 publications

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“…The application of leukotriene B 4 to skin induces itching, whereas prostaglandin E 2 , another arachidonic acid metabolite synthesized by cycloxygenase, does not (Andoh and Kuraishi, 1998). The induction of itching by leukotriene B 4 is thought to be mediated primarily by its receptor in sensory neurons, because blockers of leukotriene B 4 receptors alleviate the itching of dermatitic skin or leukotriene B 4 -induced scratches (Matsui et al, 1994;Kanai et al, 1995). However, some proportion of the itching induced by leukotriene B 4 is attributable to receptorindependent mechanisms in sensory neurons (Andoh and Kuraishi, 1998), which may include the direct action of leukotriene B 4 on TRPV1 in sensory neurons because of its agonistic activity on TRPV1 (Hwang et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

TRPV1 Mediates Histamine-Induced Itching via the Activation of Phospholipase A₂and 12-Lipoxygenase

Shim¹,

Tak²,

Lee³

et al. 2007

J. Neurosci.

410

382

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Histamine provokes itching and is a major skin disease complaint. Histamine is known to excite a subset of sensory neurons, predominantly C-fibers. Although histamine is pruritogenic, its signaling pathways that excite sensory neurons have not been identified. Because the metabolic products of lipoxygenases (LOs) activate transient receptor potential vanilloid receptor-1 (TRPV1) in sensory neurons, we hypothesized that histamine excites sensory neurons by activating TRPV1 via phospholipase A 2 (PLA 2 ) and LO stimulation. In cultured sensory neurons, histamine evoked inward currents that were reduced by capsazepine, a TRPV1 blocker. Moreover, histamine provoked inward currents when histamine receptor subtype 1 (H1R) and TRPV1 were expressed heterologously, but not when H1R or TRPV1 was expressed alone. In addition, histamine caused Ca 2ϩ influxes in sensory neurons in wild-type mice but not in TRPV1 Ϫ/Ϫ mice. Furthermore, histamine caused a 2.5-fold increase in the production of 12-hydroxyeicosatetraenoic acid, a metabolite of LO, in cultured sensory neurons. When injected subcutaneously into the necks of mice, histamine caused bouts of scratching, which were greatly reduced by pretreatment with capsazepine, a TRPV1 blocker, and by inhibitors of PLA 2 , LO, and H1R. Furthermore, mice lacking TRPV1 markedly reduced histamine-induced scratching compared with wild type. Together, these results indicate that TRPV1 plays a key role in mediating the pruritogenic action of histamine via the PLA 2 /LO pathway.

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Section: Discussionmentioning

confidence: 99%

TRPV1 Mediates Histamine-Induced Itching via the Activation of Phospholipase A₂and 12-Lipoxygenase

Shim¹,

Tak²,

Lee³

et al. 2007

J. Neurosci.

410

382

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“…One study suggested increased sensitivity to histamine in uremic patients with pruritus [17]. However, the majority of studies were not able to demonstrate any correlation between an increased plasma histamine level and uremic pruritus [14,36,38,39]. Since antihistamines are not usually effective for treating uremic itch [2], the role of histamine is likely not significant in uremic pruritus.…”

Section: Mast Cells and Autacoidsmentioning

confidence: 99%

Uremic Pruritus – An Update

2001

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“…2,[77][78][79] Because of the potential for dangerous side effects related to over-sedation, especially in the elderly, these medications cannot be recommended as first line for the treatment of CKD-aP.…”

Section: Antihistamine Treatmentmentioning

confidence: 99%

Chronic kidney disease-associated pruritus: impact on quality of life and current management challenges

Shirazian¹,

Aina²,

Park³

et al. 2017

IJNRD

112

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Chronic kidney disease-associated pruritus (CKD-aP) is a distressing, often overlooked condition in patients with CKD and end-stage renal disease. It affects ~40% of patients with end-stage renal disease and has been associated with poor quality of life, poor sleep, depression, and mortality. Prevalence estimates vary based on the instruments used to diagnose CKD-aP, and standardized diagnostic instruments are sorely needed. Treatment studies have often yielded conflicting results. This is likely related to studies that are limited by small sample size, flawed designs, and nonstandardized diagnostic instruments. Several large well-designed treatment trials have recently been completed and may soon influence CKD-aP management.

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Effects of Azelastin on Pruritus and Plasma Histamine Levels in Hemodialysis Patients

Cited by 18 publications

References 13 publications

TRPV1 Mediates Histamine-Induced Itching via the Activation of Phospholipase A₂and 12-Lipoxygenase

TRPV1 Mediates Histamine-Induced Itching via the Activation of Phospholipase A₂and 12-Lipoxygenase

Uremic Pruritus – An Update

Chronic kidney disease-associated pruritus: impact on quality of life and current management challenges

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Effects of Azelastin on Pruritus and Plasma Histamine Levels in Hemodialysis Patients

Cited by 18 publications

References 13 publications

TRPV1 Mediates Histamine-Induced Itching via the Activation of Phospholipase A2and 12-Lipoxygenase

TRPV1 Mediates Histamine-Induced Itching via the Activation of Phospholipase A2and 12-Lipoxygenase

Uremic Pruritus – An Update

Chronic kidney disease-associated pruritus: impact on quality of life and current management challenges

Contact Info

Product

Resources

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TRPV1 Mediates Histamine-Induced Itching via the Activation of Phospholipase A₂and 12-Lipoxygenase

TRPV1 Mediates Histamine-Induced Itching via the Activation of Phospholipase A₂and 12-Lipoxygenase