Effects of Azithromycin in Combination with Vancomycin, Daptomycin, Fosfomycin, Tigecycline, and Ceftriaxone on
            <i>Staphylococcus epidermidis</i>
            Biofilms

Presterl, Elisabeth; Hajdu, Stefan; Lassnigg, Andrea; Hirschl, Alexander M.; Holinka, Johannes; Graninger, Wolfgang

doi:10.1128/aac.01628-08

Cited by 30 publications

(21 citation statements)

References 36 publications

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“…In a rat cellulose-pouch methicillin-resistant Staphylococcus aureus (MRSA) biofilm model, combination therapy with vancomycin and fosfomycin resulted in the disappearance of biofilm-like structures (31). Reductions in the Staphylococcus epidermidis biofilm density were also observed with fosfomycin; the addition of azithromycin in one of the studies had no further effect on the biofilm density or bacterial eradication (32,33). The combination of prulifloxacin and fosfomycin resulted in destruction and disappearance of P. aeruginosa multilayer biofilms from the surfaces of polyethylene tubes in a urinary tract infection rat model, as seen by scanning electron microscopy (34).…”

Section: Activity In Biofilmsmentioning

confidence: 96%

Fosfomycin

et al. 2016

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SUMMARYThe treatment of bacterial infections suffers from two major problems: spread of multidrug-resistant (MDR) or extensively drug-resistant (XDR) pathogens and lack of development of new antibiotics active against such MDR and XDR bacteria. As a result, physicians have turned to older antibiotics, such as polymyxins, tetracyclines, and aminoglycosides. Lately, due to development of resistance to these agents, fosfomycin has gained attention, as it has remained active against both Gram-positive and Gram-negative MDR and XDR bacteria. New data of higher quality have become available, and several issues were clarified further. In this review, we summarize the available fosfomycin data regarding pharmacokinetic and pharmacodynamic properties, thein vitroactivity against susceptible and antibiotic-resistant bacteria, mechanisms of resistance and development of resistance during treatment, synergy and antagonism with other antibiotics, clinical effectiveness, and adverse events. Issues that need to be studied further are also discussed.

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Section: Activity In Biofilmsmentioning

confidence: 96%

Fosfomycin

et al. 2016

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“…Bacterial biofilm growth was significantly reduced by the use of antimicrobials at excessive concentrations or when antimicrobials were used in combination with azithromycin (21,37). Because the effects of antibiotics on established biofilms are unsatisfactory, other measures to reduce biofilm thickness and to kill biofilm bacteria may be helpful (37). Adjunctive therapy to enhance the activity of an antimicrobial to save an infected but unremovable implant or to improve the engraftment of a new implant after reimplantation may be a benefit for the patient (13,16).…”

mentioning

confidence: 99%

“…In a previous study, we demonstrated that the antibiotic concentrations achieved under normal physiological conditions did not decrease the growth of established staphylococcal biofilms (21). Bacterial biofilm growth was significantly reduced by the use of antimicrobials at excessive concentrations or when antimicrobials were used in combination with azithromycin (21,37). Because the effects of antibiotics on established biofilms are unsatisfactory, other measures to reduce biofilm thickness and to kill biofilm bacteria may be helpful (37).…”

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confidence: 99%

Increased Temperature Enhances the Antimicrobial Effects of Daptomycin, Vancomycin, Tigecycline, Fosfomycin, and Cefamandole on Staphylococcal Biofilms

Hajdu¹,

Holinka²,

Reichmann

et al. 2010

Antimicrob Agents Chemother

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Implant-related infections are serious complications of trauma and orthopedic surgery and are most difficult to treat. The bacterial biofilms of 34 clinical Staphylococcus sp. isolates (Staphylococcus aureus, n ‫؍‬ 14; coagulase-negative staphylococci, n ‫؍‬ 19) were incubated with daptomycin (DAP; 5, 25, or 100 mg/liter), vancomycin (VAN; 5, 25, or 100 mg/liter), tigecycline (TGC; 1, 5, or 25 mg/liter), fosfomycin (FOM; 100, 250, or 1,000 mg/liter), and cefamandole (FAM; 50, 100, or 500 mg/liter) for 24 h at three different ambient temperatures: 35°C, 40°C, and 45°C. To quantify the reduction of the biomass, the optical density ratio (ODr) of stained biofilms and the number of growing bacteria were determined. Increasing the temperature to 45°C or to 40°C during incubation with FAM, FOM, TGC, VAN, or DAP led to a significant but differential reduction of the thickness of the staphylococcal biofilms compared to that at 35°C (P < 0.05). Growth reduction was enhanced for DAP at 100 mg/liter at 35°C, 40°C, and 45°C (log count reductions, 4, 3.6, and 3.3, respectively; P < 0.05). A growth reduction by 2 log counts was detected for FAM at a concentration of 500 mg/liter at 40°C and 45°C (P ‫؍‬ 0.01). FOM at 1,000 mg/liter reduced the bacterial growth by 1.2 log counts (not significant). The antibacterial activity of antimicrobial agents is significantly but differentially enhanced by increasing the ambient temperature and using high concentrations. Adjuvant hyperthermia may be of value in the treatment of biofilm-associated implant-related infections.

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“…Several studies have investigated the effectiveness of tigecycline against biofilm-producing bacteria and yeasts and some studies compared tigecycline with other antibiotics [9,[29][30][31][32][33][34][35][36][37][38][39][40][41][42][43]. Almost all of these studies used microbiological methods.…”

Section: Discussionmentioning

confidence: 98%