Effects of azithromycin on feeding behavior and nutrition accumulation of Daphnia magna under the different exposure pathways

Li, Yang; Ma, Yunfeng; Yang, Likun; Duan, Shengzi; Zhou, Fanqi; Chen, Jianqiu; Liu, Yanhua; Zhang, Bin

doi:10.1016/j.ecoenv.2020.110573

Cited by 34 publications

(16 citation statements)

References 55 publications

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“…Those in Group C-L and C-H decreased signi cantly (p < 0.05), which associated with damage to the digestive system of D. magna. The previous study also found that the activity of AMS was decreased signi cantly after exposed to azithromycin, and the concentration-response relationship was present (Li et al, 2020). There was no signi cant difference in the AMS activities between Mix-L and control group (p > 0.05).…”

Section: Enzyme Activitymentioning

confidence: 61%

“…To avoid the growth of microalgae, all groups were conducted in the dark condition. The solution before and after 24 h of exposure in each beaker was shaken ercely to resuspended the C. pyrenoidosa cells, and the algal density was detected by ultraviolet spectrophotometry at 680 nm for calculating the feeding rate (Li et al, 2020).One D. magna was taken from each beaker, and the heartbeat of D. magna was recorded by video under Nikon SMZ1000 stereomicroscope for 2 minutes. The others D. magna were transferred into 60 mL of uncontaminated medium containing 1×10 6 cells/mL of C. pyrenoidosa.…”

Section: Feeding Behavior Experimentsmentioning

confidence: 99%

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Combined Toxicity and Toxicity Persistence of Antidepressants Citalopram and Mirtazapine to Zooplankton Daphnia Magna

Ma¹,

Li²,

Wei³

et al. 2021

Preprint

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Citalopram (CTP) and mirtazapine (MTP) are two typical psychoactive drugs used for the treatment of depression. As emerging pollutants, CTP and MTP are of widely concern because they are active substances for organisms. However, the studies about the toxicity potential of CTP/MTP pollution to aquatic organisms were limited. In the present study, the effects of CTP and MTP on the feeding behavior, heartbeat, nutritional enzymes and related gene expressions of Daphnia magna were investigated under single and mixed environmental stress. Meanwhile, the recovery of exposed D. magna was studied to analyze the toxic persistence of those pollutants. After 24 h of exposure, the ingestion rate decreased significantly under 1.45 mg/L of CTP. In the mixed treatment groups, no significant synergistic effect of CTM and MTP on daphnia’ feeding inhibition was found. After 24 h of recovery, the feeding behavior of D. magna was stimulated by compensatory stimulation. At exposure period, the heartbeat rate of exposed D. magna increased significantly, and was recovered during the recovery period. The activity of α-amylase (AMS) and trypsin, and their relative gene expression were significantly changed in most of the exposed daphnia, both in the exposure period and recovery period. But there were different responses between gene transcription with enzyme activity. In general, psychoactive drugs have an obvious toxic threat to aquatic organisms, and after acute exposure, the physiological function of D. magna could be recovered to a certain extent. The results were helpful to evaluate the ecological risk of psychotropic drugs in aquatic environments.

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Section: Enzyme Activitymentioning

confidence: 61%

Section: Feeding Behavior Experimentsmentioning

confidence: 99%

Combined Toxicity and Toxicity Persistence of Antidepressants Citalopram and Mirtazapine to Zooplankton Daphnia Magna

Ma¹,

Li²,

Wei³

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Enzyme Activitymentioning

confidence: 72%

“…The solution before and after 24-h exposure and 24-h recovery in each beaker were shaken ercely to resuspended the C. pyrenoidosa cells. The algal density was detected by spectrophotometry at 680 nm for calculating the feeding rate (Li et al, 2020). One D. magna was taken from each beaker, and the heartbeat of D. magna was recorded by video under Nikon SMZ1000 stereomicroscope for 2 minutes.…”

Section: Feeding Behavior Experimentsmentioning

confidence: 99%

Combined Toxicity and Toxicity Persistence of Antidepressants Citalopram and Mirtazapine to Zooplankton Daphnia Magna

Dong

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Citalopram (CTP) and mirtazapine (MTP) are two typical psychoactive drugs used for the depression treatment. As emerging pollutants, CTP and MTP has been given widely concern because they are active substances for organisms. Therefore, the ecotoxicological risks of aquatic organisms should be paid more attention to. In this study, the effects of CTP and MTP on the feeding behavior, heartbeat, nutritional enzymes and related gene transcriptions of Daphnia magna were investigated under single and mixed environmental stress. Meanwhile, the recovery of exposed D. magna was studied to analyze the toxic persistence of those pollutants. After 24-hexposure, the ingestion rate decreased by 34.2% and 21.5%, in the group of C-H and Mix-H respectively. After 24-h recovery, the feeding behavior of D. magna was stimulated by compensatory stimulation. In exposure period, the heartbeat rate of D. magna increased by 132.3%, 69%, 111.9%, 139.4%, and 92.4%, in the group of C-L, C-H, M-L, M-H and Mix-L respectively, and was recovered during the recovery period. The activity of α-amylase (AMS) and trypsin were significantly changed in most of the exposed daphnia, both in the exposure period and recovery period. CTP/MTP exposure stimulated transcription of the α-amylase gene. M-H and Mix-H exposure inhibited transcription of the trypsin gene and other stimulated transcriptions. After 24-h recovery, the stimulative or inhibitory effects were alleviated. There were different responses between gene transcription and enzyme activity. In conclusion, our results highlighted the toxic effects of single and mixed pollution of CTP and MTP on feeding, heartbeat, enzymes and genes of D. magna.

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“…Furthermore, azithromycin had also been shown to inhibit growth, accumulation of crude fat, polysaccharides, and total protein content in C. pyrenoidosa. 165 Further studies by Fu et al 2017 tested the toxicity of 13 antibiotics for their toxicity towards freshwater green algae. Out of the 13 antibiotics, azithromycin was shown to have the highest toxicity.…”

Section: Impact Of Pharmaceuticals On the Ecosystemmentioning

confidence: 99%

A review of pharmaceutical occurrence and pathways in the aquatic environment in the context of a changing climate and the COVID-19 pandemic

et al. 2021

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Effects of azithromycin on feeding behavior and nutrition accumulation of Daphnia magna under the different exposure pathways

Cited by 34 publications

References 55 publications

Combined Toxicity and Toxicity Persistence of Antidepressants Citalopram and Mirtazapine to Zooplankton Daphnia Magna

Combined Toxicity and Toxicity Persistence of Antidepressants Citalopram and Mirtazapine to Zooplankton Daphnia Magna

Combined Toxicity and Toxicity Persistence of Antidepressants Citalopram and Mirtazapine to Zooplankton Daphnia Magna

A review of pharmaceutical occurrence and pathways in the aquatic environment in the context of a changing climate and the COVID-19 pandemic

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