Effects of B Vitamins Overload on Plasma Insulin Level and Hydrogen Peroxide Generation in Rats

Abstract

It has been reported that nicotinamide-overload induces oxidative stress associated with insulin resistance, the key feature of type 2 diabetes mellitus (T2DM). This study aimed to investigate the effects of B vitamins in T2DM. Glucose tolerance tests were carried out in adult Sprague-Dawley rats treated with or without cumulative doses of B vitamins. More specifically, insulin tolerance tests were also carried out in adult Sprague-Dawley rats treated with or without cumulative doses of Vitamin B3. We found that cumulative Vitamin B1 and Vitamin B3 administration significantly increased the plasma H₂O₂ levels associated with high insulin levels. Only Vitamin B3 reduced muscular and hepatic glycogen contents. Cumulative administration of nicotinic acid, another form of Vitamin B3, also significantly increased plasma insulin level and H₂O₂ generation. Moreover, cumulative administration of nicotinic acid or nicotinamide impaired glucose metabolism. This study suggested that excess Vitamin B1 and Vitamin B3 caused oxidative stress and insulin resistance.

Toxicogenetic study of omeprazole and the modulatory effects of retinol palmitate and ascorbic acid on Allium cepa

“…However, the observed effects of RP and/or AA were more prominent with the modulation of up to 70% of OME-induced mutagenicity in A. cepa. There are reports that the association of vitamins has importance in the protection and inhibition of oxidative effects (Sun et al, 2017) and prevention of risks for several types of cancer, such as adenomas (Xu et al, 2013), colon (Heine-Bröring et al, 2015), ovary (Koushik et al, 2015, prostate (Tomasetti et al, 2012) and especially for gastric cancer (Kong et al, 2014).…”

Antidiabetic effect of an engineered bacterium Lactobacillus plantarum-pMG36e -GLP-1 in monkey model

“…This increases the likelihood that obesity and T2DM may be related to excessive intake of B vitamins. It has been reported that excess vitamins B6 metabolism significantly increases plasma H 2 O 2 levels [ 51 ]. The level of pyruvic acid is also higher in T2DM patients [ 52 ].…”