Effects of Bacteriophage Therapy on Host Immune Responses in Brucellosis Affected Cattle

Mohan, Anju; Saxena, Hari Mohan

doi:10.31080/asmi.2020.03.0622

Cited by 1 publication

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“…The average titers of cattle naturally infected with brucellosis (n = 15) and healthy analogs (n = 6) vaccinated as calves with B. abortus 19 differed significantly according to the IHA, TAT, and microagglutination test (MAT), whereas there were no significant differences between the groups using ELISA. In another study [ 37 ], they investigated the effects of bacteriophage therapy on the immune responses of naturally infected cows. IHA detected the highest antibody titer in infected cows on day 0, and toward the end of the experiment, its sensitivity was significantly higher than that of ELISA and MAT.…”

Section: Blood Serum-based Iha For Brucellosis Diagnosismentioning

confidence: 99%

Indirect hemagglutination assay for diagnosing brucellosis: Past, present, and future

Mikailov,

Gunashev,

Yanikova

et al. 2024

Vet World

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Brucellosis is a zoonotic disease that causes enormous losses in livestock production worldwide and has a significant public health impact. None of the brucellosis-free countries is currently able to guarantee their ability to prevent the introduction of the pathogen due to the increase in tourism and the expansion of migration. The timely identification of infected animals is an effective means of preventing brucellosis and minimizing the epidemiological risk. The tube agglutination test, Rose Bengal plate test, complement fixation test, and enzyme-linked immunosorbent assay, which are routinely used to identify seropositive productive animals, have limitations and results that do not always correlate. The indirect hemagglutination assay (IHA) stands out among non-traditional methods because it is affordable, has a simple protocol, and is more reliable than classical serological tests, especially in cases of questionable and/or false-negative results. The diagnostic value of the IHA has long been studied by laboratories in several countries, but mostly by post-soviet research teams; therefore, the results continue to be published in Russian-language journals, ensuring that the local scientific community can access the results. In addition, the efficacy of this test for the diagnosis of brucellosis and other infectious diseases has not yet been reviewed. The purpose of this review was to summarize the results of studies on the development and use of IHA for the diagnosis of brucellosis and to determine the prospects for further improvement Keywords: brucellosis, diagnostic value, indirect hemagglutination assay, prospects for improving the test, serological tests.

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Section: Blood Serum-based Iha For Brucellosis Diagnosismentioning

confidence: 99%