Effects of baicalin in CD4 + CD29 + T cell subsets of ulcerative colitis patients

Yu, Fang; Huang, Shiying; Zhang, Haiyan; Ye, Hua; Chi, Honggang; Zou, Ying; Lv, Ruxi; Xiao, Zheng

doi:10.3748/wjg.v20.i41.15299

Cited by 39 publications

(28 citation statements)

References 31 publications

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“…Clinical trials with baicalin adjunctive therapy have focused on its protective roles in ulcerative colitis, hepatic fibrosis, and diabetes mellitus [30–32], and several studies have investigated the potential of baicalin in treating patients with early diabetic nephropathy, in which baicalin inhibits aldose reductase activity and reduces urinary albumin excretion rate and the blood β2-microglobulin [33]. The present study further discovered the protective role of baicalin against AKI in pediatric sepsis patients, which was reflected in the reduced BUN and Cr levels.…”

Section: Discussionmentioning

confidence: 99%

Baicalin Inhibits Renal Cell Apoptosis and Protects Against Acute Kidney Injury in Pediatric Sepsis

Zhu

2016

Med Sci Monit

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BackgroundPediatric sepsis has high morbidity in children, may lead to acute kidney injury (AKI), and further aggravate the disease. Baicalin is a kind of flavonoid in Scutellaria baicalensis Georgi and has been reported to protect against several diseases, but its roles in septic AKI remain unclear. This study aimed to uncover the effects of baicalin in AKI during pediatric sepsis.Material/MethodsBlood urea nitrogen (BUN) and serum creatinine (Cr) levels were detected in 50 pediatric patients, who underwent basic therapy with or without baicalin adjunctive therapy. Mouse sepsis models were constructed by cecal ligation and puncture (CLP) and treated with baicalin intragastrically, after which BUN and Cr examination, TUNEL apoptosis assay, and expression analyses of BAX and BCL2 were performed.ResultsBaicalin adjunctive therapy significantly decreased BUN and Cr levels in pediatric sepsis patients (P<0.05). CLP led to elevated BUN and Cr levels in the mouse model (P<0.01), indicating kidney injury accompanied by sepsis. Baicalin decreased BUN and Cr levels (P<0.05), and reduced the apoptotic cell percent in the renal tissue (P<0.05) of the CLP model. It inhibited BAX and promoted BCL2 in the renal tissue, which was consistent with cell apoptosis changes.ConclusionsBaicalin is capable of suppressing renal cell apoptosis and protecting against AKI in pediatric sepsis. This study provides a potential adjunctive therapy for treating AKI in pediatric sepsis, and further research is necessary to reveal its deeper mechanisms.

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Section: Discussionmentioning

confidence: 99%

Baicalin Inhibits Renal Cell Apoptosis and Protects Against Acute Kidney Injury in Pediatric Sepsis

Zhu

2016

Med Sci Monit

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“…It is reported that baicalin (50, 100 or 150 mg/kg) treatment significantly reduces interleukin (IL)-33 and NF-κBp65 levels, and increases IκBα levels against the severity of UC in DSS-induced mice [45]. Moreover, treatment with baicalin (20 and 40 μmol/L) obviously up-regulates expression of IL-4 and IL-10, increases ratio of p-STAT6/ STAT6, but decreases ratios of p-STAT4/STAT4 and p-NF-κB/NF-κB compared to the treatment of no baicalin in UC patients [46]. In addition, evidence indicates that wogonin (25 mg/mL) treatment obviously attenuates the inflammatory response of toll like receptor (TLR4)-myeloid differentiation factor (MyD) 88-mediated NF-κB pathway in lipopolysaccharide (LPS)-induced intestinal inflammation of Caco-2 cells in vitro, suggesting protective function on intestinal mucosal barrier [47].…”

Section: Heat-clearing and Dampness-drying Medicinementioning

confidence: 91%

“…Heat-clearing and dampness-drying medicine Casticin RAW264.7 Repress the NF-κBp65 nucleus translocation [44] Baicalin DSS-induced colon tissue Reduce the protein levels of NF-κBp65 and p-NF-κBp65 [45] UC patients Decrease ratios of p-NF-κB/NF-κB [46] Wogonin Caco-2 cells Decrease NF-κB activity [47] Wogonoside DSS-induced colon tissues Inhibit nuclear translocation of NF-κBp65, phosphorylated p65 and NF-κB DNA binding activity [48] AOM/DSS-induced tumor tissues…”

Section: Chinese Medicines Models Mechanisms Referencesmentioning

confidence: 99%

Targeting NF-κB pathway for treating ulcerative colitis: comprehensive regulatory characteristics of Chinese medicines

Zhao

2020

Chin Med

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Nuclear factor-kappa B (NF-κB) is a kind of multi-functional nuclear transcription factor involved in regulating gene transcription to influence pathological evolution of inflammatory and immune diseases. Numerous literature evidence that NF-κB pathway plays an essential role in pathogenic development of ulcerative colitis (UC). UC is a chronic non-specific inflammatory bowel disease, and until now, therapeutic agents for UC including aminosalicylates, corticosteroids and immune inhibitors still cannot exert satisfied effects on patients. In recent years, Chinese medicines suggest the advantages of alleviating symptoms and signs, decreasing side-effects and recurrence, whose one of mechanisms is related to regulation of NF-κB pathway. In this review, we categorize Chinese medicines according to their traditional therapeutic functions, and summarize the characteristics of Chinese medicines targeting NF-κB pathway in UC treatment. It indicates that 85 kinds of Chinese medicines' compounds and formulae can directly act on NF-κBp65; while 58 Chinese medicines' ingredients and formulae indirectly suppress NF-κBp65 by regulation of its upstream or other related pathways. Moreover, by the analysis of Chinese medicines' category based on their traditional functions, we conclude the category of dampness-drying and detoxificating medicine targeting NF-κB pathway accounts for primary status for amelioration of UC. Simultaneously, this review also contributes to the choices of Chinese medicine category and provides curative potential of Chinese medicines for clinical UC treatment.

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“…Baicalin, 7-glucuronic acid, 5,6-dihydroxy-flavone, is an extracted flavonoid compound from Scutellaria baicalensis Georgi and has potent anti-inflammatory activity [11][12][13]. Baicalin has been used for the treatment of ulcerative colitis [14], endotoxemia [15], periodontitis [16] and various inflammatory diseases [17,18]. Other studies have shown that baicalin promotes human periodontal ligament cell (HPLC) proliferation, reduces the ratio of receptor activator of nuclear factor-kappaB ligand (RANKL) to osteoprotegerin (OPG) expression [19], cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) activity [16], interleukin-6 (IL-6) and IL-8 expression [20], and protects against tissue damage in animal models of periodontitis [16].…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 99%

Baicalin inhibits toll-like receptor 2/4 expression and downstream signaling in rat experimental periodontitis

Sun

Dong

et al. 2016

International Immunopharmacology

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Effects of baicalin in CD4 + CD29 + T cell subsets of ulcerative colitis patients

Abstract: The results indicate that baicalin regulates immune balance and relieves the ulcerative colitis-induced inflammation reaction by promoting proliferation of CD4(+)CD29(+) cells and modulating immunosuppressive pathways.

Cited by 39 publications

References 31 publications

Baicalin Inhibits Renal Cell Apoptosis and Protects Against Acute Kidney Injury in Pediatric Sepsis

Baicalin Inhibits Renal Cell Apoptosis and Protects Against Acute Kidney Injury in Pediatric Sepsis

Targeting NF-κB pathway for treating ulcerative colitis: comprehensive regulatory characteristics of Chinese medicines

Baicalin inhibits toll-like receptor 2/4 expression and downstream signaling in rat experimental periodontitis

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