Effects of Baicalin on Blood Pressure and Left Ventricular Remodeling in Rats with Renovascular Hypertension

Dai, Hualei; Xinjin, Zhang; Yang, Zhi‐gang; Li, Jianmei; Zheng, Jialin

doi:10.12659/msm.902536

Cited by 18 publications

(17 citation statements)

References 37 publications

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“…BAI, along with its metabolite baicalein have many targets and may have protective effects on diverse diseases. The previous studies found that BAI had effects on neuroprotective, renovascular hypertension, cancer, obesity, and liver dysfunction (Dai et al, 2017;Sowndhararajan et al, 2018;Tang et al, 2016;Xi et al, 2015). However, it has been unclear that the effects and mechanisms of BAI on PD treatment.…”

Section: Discussionmentioning

confidence: 99%

Baicalin attenuated substantia nigra neuronal apoptosis in Parkinson’s disease rats via the mTOR/AKT/GSK-3β pathway

Zhai,

Kang,

Zhang

et al. 2019

J. Integr. Neurosci.

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This focus of our research is to investigate the protective effect of Baicalin on apoptosis and mTOR/AKT/GSK-3β pathway in substantia nigra neurons in a rat model for Parkinson's disease, induced by 6-Hydroxydopamine. Thirty healthy female Sprague-Dawley rats were randomly divided into control group, model group, and Baicalin group. The Parkinson model was established by injecting 6-Hydroxydopamine into the right substantia nigra of rats in model and Baicalin group. The rats in Baicalin group were intragastrically administered with Baicalin (25 mg/kg/day) for four weeks. At the same time, the rats in control and model groups were intragastrically administered with equivalent solvents. We observed the rat turns, rotation speed and left forelimb usage. The protein expression levels of α-SYN, mTOR, AKT, and GSK-3β in substantia nigra were detected by immunohistochemistry and Western blotting. Compared with model group, Baicalin significantly reduced the number of rotation speeds and neuron apoptosis (P < 0.001, respectively). However, the left forelimb use rate was notably increased after treatment with Baicalin (P < 0.001, respectively). Also, Baicalin decreased the expression levels of α-SYN, mTOR, AKT, and GSK-3β in rats when compared with those in model group (P < 0.001, respectively).

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Section: Discussionmentioning

confidence: 99%

Baicalin attenuated substantia nigra neuronal apoptosis in Parkinson’s disease rats via the mTOR/AKT/GSK-3β pathway

Zhai,

Kang,

Zhang

et al. 2019

J. Integr. Neurosci.

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“…Hypertensive heart disease is one of the most common complications and can lead to death in hypertensive patients. Therefore, it is an important strategy to improve ventricular remodelling and to prevent hypertensive heart disease for the reduction of the morbidity and mortality of hypertensive patients …”

Section: Discussionmentioning

confidence: 99%

“…Therefore, it is an important strategy to improve ventricular remodelling and to prevent hypertensive heart disease for the reduction of the morbidity and mortality of hypertensive patients. [19,20] In this study, we examined the function of left ventricular at the 18, 22 and 26 weeks of age in SHRs. The results showed that the LVPW became thickened with age in the SHR group, while the EF and FS decreased, indicating that SHRs exhibited ventricular remodelling and dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Icariside II prevents hypertensive heart disease by alleviating endoplasmic reticulum stress via the PERK/ATF-4/CHOP signalling pathway in spontaneously hypertensive rats

Yue

et al. 2019

Journal of Pharmacy and Pharmacology

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Objectives Reducing endoplasmic reticulum stress (ERS)‐induced cardiomyocyte apoptosis is a key strategy for preventing hypertensive heart disease. In our previous study, Icariside II can improve left ventricular remodelling in spontaneously hypertensive rats (SHRs). This study aims to determine whether Icariside II can exert its effect by inhibiting ERS‐induced cardiomyocyte apoptosis via the PERK/ATF‐4/CHOP signalling pathway. Methods Spontaneously hypertensive rats were randomly divided into model group and Icariside II groups. The rats in the Icariside II groups were intragastrically administrated with Icariside II 4, 8 and 16 mg/kg from 14 to 26 week‐age, respectively. The left ventricular function was measured at the 18, 22 and 26 week‐age by small animal ultrasound. At the end of the 26th week, cardiomyocyte apoptosis was analysed and the levels of GRP78, PERK, ATF‐4 and CHOP gene and protein were detected. Key findings The function of left ventricular became declined with age in SHRs, but improved in Icariside II groups. Myocardial apoptosis was aggravated in SHRs, but alleviated in Icariside II groups. Icariside II could reduce the levels of GRP78, PERK, ATF‐4, CHOP gene and protein that increased in SHRs. Conclusions Icariside II prevents hypertensive heart disease by alleviating ERS‐induced cardiomyocyte apoptosis, and its mechanism is related to the impediment of the PERK/ATF‐4/CHOP signalling pathway.

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“…Baicalin has been widely studied in several in vitro and in vivo models and showed many activities such as: anti-viral [42], anti-oxidative via several pathways [43], neuroprotective and enhancin cognitive functions [44,45], anti-inflammatory [46], anti-cancer [47,48], and hepatoprotection [49]. In recent years, many studies showed anti-hypertensive properties of baicalin [46,[50][51][52][53][54][55][56][57][58][59][60], and also cardioprotective [50], antiplatelet, anticoagulant, and profibrinolytic activities [61].…”

Section: Influence In Pregnancymentioning

confidence: 99%

“…On the other hand, studies in rats with renovascular hypertension showed that baicalin (2 ml of 100 mg/kg baicalin i.p. for 4 weeks once a day) has no significant antihypertensive effect [52]. Baicalein (aglycon of baicalin) protected against hypertension associated with diabetes and showed decrease of vascular deleterious effects associated with both insulin deficiency (ID) and insulin resistance (IR) models.…”

Section: In Vivo Studies Related To the Various Models Of Hypertensionmentioning

confidence: 99%

In vitro and in vivo activities of flavonoids – apigenin, baicalin, chrysin, scutellarin – in regulation of hypertension – a review for their possible effects in pregnancy-induced hypertension

et al. 2019

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Summary Flavonoids and their conjugates are the most important group of natural chemical compounds in drug discovery and development. The search for pharmacological activity and new mechanisms of activity of these chemical compounds, which may inhibit mediators of inflammation and influence the structure and function of endothelial cells, can be an interesting pharmacological strategy for the prevention and adjunctive treatments of hypertension, especially induced by pregnancy. Because cardiovascular diseases have multi-factorial pathogenesis these natural chemical compounds with wide spectrum of biological activities are the most interesting source of new drugs. Extracts from one of the most popular plant used in Traditional Chinese Medicine, Scutellaria baicalensis Georgi could be a very interesting source of flavonoids because of its exact content in quercetin, apigenin, chrysin and scutellarin as well as in baicalin. These flavonoids exert vasoprotective properties and many activities such as: anti-oxidative via several pathways, anti-in-flammatory, anti-ischaemic, cardioprotective and anti-hypertensive. However, there is lack of summaries of results of studies in context of potential and future application of flavonoids with determined composition and activity. Our review aims to provide a literature survey of in vitro, in vivo and ex vivo pharmacological studies of selected flavonoids (apigenin, chrysin and scutellarin, baicalin) in various models of hypertension carried out in 2008–2018.

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Effects of Baicalin on Blood Pressure and Left Ventricular Remodeling in Rats with Renovascular Hypertension

Cited by 18 publications

References 37 publications

Baicalin attenuated substantia nigra neuronal apoptosis in Parkinson’s disease rats via the mTOR/AKT/GSK-3β pathway

Baicalin attenuated substantia nigra neuronal apoptosis in Parkinson’s disease rats via the mTOR/AKT/GSK-3β pathway

Icariside II prevents hypertensive heart disease by alleviating endoplasmic reticulum stress via the PERK/ATF-4/CHOP signalling pathway in spontaneously hypertensive rats

In vitro and in vivo activities of flavonoids – apigenin, baicalin, chrysin, scutellarin – in regulation of hypertension – a review for their possible effects in pregnancy-induced hypertension

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