2020
DOI: 10.4103/pm.pm_261_19
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Effects of baicalin on pharmacokinetics of florfenicol and mRNA expression of CYP1A2, CYP2C11, CYP3A1, UGT1A1, MDR1, and ABCC2 in rats

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Cited by 3 publications
(3 citation statements)
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“…In our previous study, we found that anemoside B4, the major effective saponin in Pulsatillae radix, could decrease the plasma concentration of florfenicol [14]. In addition, we also found that baicalin could affect the pharmacokinetics of florfenicol in rats and increase the plasma concentration and residence time of florfenicol [15].…”
Section: Introductionmentioning
confidence: 92%
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“…In our previous study, we found that anemoside B4, the major effective saponin in Pulsatillae radix, could decrease the plasma concentration of florfenicol [14]. In addition, we also found that baicalin could affect the pharmacokinetics of florfenicol in rats and increase the plasma concentration and residence time of florfenicol [15].…”
Section: Introductionmentioning
confidence: 92%
“…On the eighth day, after fasting for 12 hr, a suspension containing florfenicol (25 mg/kg BW) [15] was intragastrically administered to all rats in both groups. Blood samples (200 μl) from each rat were collected via the oculi chorioideae vein at 0.083, 0.25, 0.50, 0.75, 1, 2, 4, 6, 8, 10, 12, and 24 hr after administration of florfenicol.…”
Section: Pharmacokinetic Studymentioning
confidence: 99%
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