Effects of Bariatric Surgeries on Fetuin-A, Selenoprotein P, Angiopoietin-Like Protein 6, and Fibroblast Growth Factor 21 Concentration

Poloczek, Jakub; Kazura, Wojciech; Kwaśnicka, Ewa; Gumprecht, Janusz; Jochem, Jerzy; Stygar, Dominika

doi:10.1155/2021/5527107

Cited by 7 publications

(5 citation statements)

References 81 publications

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“… 26 Moreover, hepatokine secretion generally improves after bariatric surgery, which might drive the long-term metabolic improvements following bariatric surgery. 27 Recently, studies found that plasma FGL-1 levels are associated with obesity, NAFLD, and T2DM. 15 , 16 , 24 However, the role of FGL-1 in obese patients who undergo LSG remains obscure, and the current study explored whether FGL-1 changes after LSG are correlated with other metabolic indices.…”

Section: Discussionmentioning

confidence: 99%

Serum Fibrinogen-Like Protein 1 Levels in Obese Patients Before and After Laparoscopic Sleeve Gastrectomy: A Six-Month Longitudinal Study

Dilimulati¹,

Du²,

Huang³

et al. 2022

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Purpose Fibrinogen-like protein (FGL)-1 is an original hepatokine with a critical role in developing hepatic steatosis. This study intends to examine the pre- and postoperative serum FGL-1 levels in bariatric patients and identify its relationship with other clinical indicators. Patients and Methods Ninety-two individuals (60 bariatric patients and 32 people with normal weight) were enrolled in this research between July 2018 and April 2021. All bariatric patients finished follow-up visits 6 months after laparoscopic sleeve gastrectomy (LSG). Clinical data, anthropometric parameters, biochemical variables, FibroScan, and serum FGL-1 levels were collected at baseline and 6 months after LSG. Results FGL-1 levels in patients with obesity (44.66±20.03 ng/mL) were higher than in individuals with normal weight (20.73±9.73 ng/mL, p < 0.001). After LSG, FGL-1 levels were significantly decreased (27.53±11.45 ng/mL, p < 0.001). Besides, body mass index (BMI), liver enzyme levels, glucose metabolism, lipid metabolism, uric acid (UA), controlled attenuation parameter (CAP), and liver stiffness measurement (LSM) were significantly improved. After adjusting possible confounders, FGL-1 levels at baseline were negatively associated with changes in LSM levels; changes in FGL-1 levels showed positive correlations with changes in alanine aminotransferase (ALT), aspartate aminotransferase (AST) and UA levels at 6 months after surgery. Conclusion Serum FGL-1 levels were significantly decreased following LSG in patients with obesity. The preoperative serum FGL-1 levels could be a predictor of postoperative liver fibrosis improvement. Furthermore, the decreased FGL-1 levels were associated with improved liver enzymes and UA but not with bodyweight or glucolipid metabolism.

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Section: Discussionmentioning

confidence: 99%

Serum Fibrinogen-Like Protein 1 Levels in Obese Patients Before and After Laparoscopic Sleeve Gastrectomy: A Six-Month Longitudinal Study

Dilimulati¹,

Du²,

Huang³

et al. 2022

DMSO

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“…Moreover, post-surgical hepatic ANGPTL8 transcripts were inversely related to liver TG content and transaminase AST, supporting the hepatoprotective action of ANGPTL8 against liver steatosis. In line with this observation, metabolic adaptations after bariatric surgery include modulations in the production of hepatokines, such as fetuin-A, selenoprotein P, adropin, sex-hormone-binding globulin (SHBG), insulin-like growth factor binding protein (IGFBP)-2 or fibroblast growth factor 21 (FGF-21), but literature on patients is scarce [ 36 , 37 , 38 ]. The results of the impact of bariatric surgery on hepatokine ANGPTL8 levels are not univocal.…”

Section: Discussionmentioning

confidence: 99%

Role of ANGPTL8 in NAFLD Improvement after Bariatric Surgery in Experimental and Human Obesity

Perdomo

Gómez-Ambrosi

Becerril

et al. 2021

IJMS

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Angiopoietin-like protein 8 (ANGPTL8) is an hepatokine altered in several metabolic conditions, such as obesity, type 2 diabetes, dyslipidemia and nonalcoholic fatty liver disease (NAFLD). We sought to explore whether ANGPTL8 is involved in NAFLD amelioration after bariatric surgery in experimental models and patients with severe obesity. Plasma ANGPTL8 was measured in 170 individuals before and 6 months after bariatric surgery. Hepatic ANGPTL8 expression was evaluated in liver biopsies of patients with severe obesity undergoing bariatric surgery with available liver pathology analysis (n = 75), as well as in male Wistar rats with diet-induced obesity subjected to sham operation, sleeve gastrectomy or Roux-en-Y gastric bypass (RYGB) (n = 65). The effect of ANGPTL8 on lipogenesis was assessed in human HepG2 hepatocytes under palmitate-induced lipotoxic conditions. Plasma concentrations and hepatic expression of ANGPTL8 were increased in patients with obesity-associated NAFLD in relation to the degree of hepatic steatosis. Sleeve gastrectomy and RYGB improved hepatosteatosis and reduced the hepatic ANGPTL8 expression in the preclinical model of NAFLD. Interestingly, ANGPTL8 inhibited steatosis and expression of lipogenic factors (PPARG2, SREBF1, MOGAT2 and DGAT1) in palmitate-treated human hepatocytes. Together, ANGPTL8 is involved in the resolution of NAFLD after bariatric surgery partially by the inhibition of lipogenesis in steatotic hepatocytes.

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“…Together with stress and chronobiological rhythm disruption, also characteristic of modern Western lifestyle, there is a further contribution to the increase in metabolic syndrome prevalence [ 4 ]. On the physiological level, obesity results in oxidative stress and chronic low-grade inflammation [ 7 , 8 , 9 ] that is controlled by the various factors keeping equilibrium between pro- and antioxidative processes [ 10 , 11 , 12 ]. Oxidative stress was observed in experimental diabetes as early as 1982 [ 13 ], and it has been found to play an essential role in all cases of diabetes mellitus (particularly type 2 diabetes mellitus, T2DM) and the pathogenesis of diabetic complications.…”

Section: Introductionmentioning

confidence: 99%

“…In turn, high levels of reactive oxygen species (ROS) can act as secondary messengers and regulate the biological function of various proteins. The dynamic modification of intracellular redox sensors by ROS is defined as redox modification and is similar to other posttranslational modifications such as protein phosphorylation, acetylation, or ubiquitination, which play an important role in diabetes development [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, nutritional therapy often fails in morbidly obese patients, and for such patients, bariatric surgery remains the only reliable option [ 14 ] to ensure permanent weight loss. Additionally, bariatric surgery induces positive changes in glucose tolerance, thus providing diabetes control [ 15 , 16 ], as well as in signaling pathways and concentrations of different proteins [ 10 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Duodenojejunal Omega Switch Surgery Reduces Oxidative Stress Induced by Cafeteria Diet in Sprague-Dawley Rats

et al. 2022

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Over-nutrition with cafeteria diet leads to glycemic control failure and subsequent obesity. Bariatric surgery remains the ultimate treatment option, and when complemented with specific dietary protocol, it may mitigate the effects of oxidative stress induced by a cafeteria diet. The study measured antioxidant marker activity: superoxidase dismutase (SOD) and ceruloplasmin (CER), total antioxidant capacity (TAC), and lipid peroxidation marker concentrations: lipofuscin (LS) and malondialdehyde (MDA), in the plasma of 56 Sprague-Dawley rats fed with a cafeteria (HFS) or a control (CD) diet and subjected to duodenojejunal omega switch (DJOS) or control (SHAM) surgery. The diet change after the surgery (CD/HFS or HFS/CD) strongly influenced SOD activity in DJOS- and SHAM-operated rats, but SOD activity was always higher in SHAM-operated rats. Every dietary protocol used in the study increased CER activity, except for the CD/CD combination. Cafeteria diet consumed before or after either of surgeries led to decrease in TAC levels. DJOS and no change in diet reduced MDA levels. DJOS reduced LS levels, but its beneficial effect was deteriorated by selected dietary protocols. The cafeteria diet negatively affected the positive impact of DJOS surgery, but SOD, CER, MDA, and LS were significantly lower in rats that underwent DJOS, suggesting that eight weeks of dietary treatment before and after the surgery did not totally dilapidate the effects of the bariatric treatment.

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Effects of Bariatric Surgeries on Fetuin-A, Selenoprotein P, Angiopoietin-Like Protein 6, and Fibroblast Growth Factor 21 Concentration

Cited by 7 publications

References 81 publications

Serum Fibrinogen-Like Protein 1 Levels in Obese Patients Before and After Laparoscopic Sleeve Gastrectomy: A Six-Month Longitudinal Study

Serum Fibrinogen-Like Protein 1 Levels in Obese Patients Before and After Laparoscopic Sleeve Gastrectomy: A Six-Month Longitudinal Study

Role of ANGPTL8 in NAFLD Improvement after Bariatric Surgery in Experimental and Human Obesity

Duodenojejunal Omega Switch Surgery Reduces Oxidative Stress Induced by Cafeteria Diet in Sprague-Dawley Rats

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