Effects of bayberry juice on inflammatory and apoptotic markers in young adults with features of non-alcoholic fatty liver disease

Guo, Honghui; Zhong, Ruimin; Liu, Yongji; Jiang, Xinwei; Tang, Xilan; Li, Zhen; Xia, Min; Liu, Wenhua

doi:10.1016/j.nut.2013.07.023

Cited by 85 publications

(70 citation statements)

References 27 publications

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“…[24][25][26] Other two studies were carried out using 150 mg polyphenols (1.43% of flavonoids, 2.5% anthocyanins and 1.7% phenolic acid) extract of Hibiscus sabdariffa L. or 1350 mg of bayberry juice, daily for 12 weeks and 4 weeks in overweight and in young adults with NAFLD, respectively. [27,28] Finally, one study utilized 250 mL of pomegranate juice or orange juice per day associated with hypocaloric diet over a period of 12 weeks. [29] Some studies reported a significant impact of polyphenols' importance on NAFLD.…”

Section: Polyphenols and Nafldmentioning

confidence: 99%

“…[25] The polyphenols used by humans through consumption of the bayberry juice and resveratrol showed anti-inflammatory effects, with a reduction in serum cytokines and in particular of TNF-α, interelukin-6 and -8, and increased serum levels of adiponectin. [24,25,28] In addition, Faghihzadeh et al described a reduction in NF-κB activity in the peripheral blood mononuclear cells. [24] Finally, Ekhlasi et al reported the reduction of high liver enzymes and improvement of total antioxidant capacity in the NAFLD patients treated with pomegranate juice.…”

Section: Polyphenols and Nafldmentioning

confidence: 99%

“…However, the information obtained by non-invasive tools like the liver ultrasound reported a significant improvement of liver damage and liver steatosis degree when polyphenol supplementation is associated with lifestyle changes. [24,25,28] CONCLUSION NAFLD is the liver board of over nutrition and an upcoming challenge for hepatologists and health systems worldwide. Patients with liver steatosis have an increased prevalence of chronic diseases.…”

Section: Polyphenols and Nafldmentioning

confidence: 99%

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Polyphenols treatment in patients with nonalcoholic fatty liver disease

Abenavoli

Milić

Luzza

et al. 2017

Journal of Translational Internal Medicine

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Nonalcoholic fatty liver disease (NAFLD) affects 25−30% of the general population worldwide and this high prevalence is linked with lifestyle and dietetic changes, not only in Western countries, but also in the urban areas of developing countries. Several pharmacological approaches were proposed in the treatment of NAFLD, but the reported results are inconclusive. International guidelines recommended the reduction of dietary fat and fructose, in association with some physical activity. In this context, it was reported that the protective effects of traditional Mediterranean diet, related to the high concentration of antioxidant compounds, particularly of polyphenols. Polyphenols are a heterogeneous class of plant derived compounds, with some proven hepatoprotective effects. Our opinion is that the adherence to traditional Mediterranean diet characterized by the consumption of antioxidant-rich foods in general and of polyphenols in particular, can be considered as a potential new approach in the treatment of NAFLD.

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Section: Polyphenols and Nafldmentioning

confidence: 99%

Section: Polyphenols and Nafldmentioning

confidence: 99%

Section: Polyphenols and Nafldmentioning

confidence: 99%

See 1 more Smart Citation

Polyphenols treatment in patients with nonalcoholic fatty liver disease

Abenavoli

Milić

Luzza

et al. 2017

Journal of Translational Internal Medicine

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“…Polyphenols from pomegranate flowers seem to improve also insulin resistance and steatosis in rats with diabetes and non-alcoholic fat liver disease, probably by enhancing PON1 expression in the liver [135]. In the same way, polyphenolic extracts obtained from blueberries [136,137], mulberries [137] and bayberries [138] show preventive effects on NAFLD, inhibiting body weight gain, decreasing serum cholesterol, reducing insulin resistance and attenuating lipid accumulation, as well as improving plasma antioxidant status and inhibiting the inflammatory and apoptotic responses. Likewise, polyphenolic extract from lotus root, the edible rhizome of Nelumbo nucifera, rich in proanthocyanidins, alleviates hepatic steatosis by suppressing lipogenic enzymes activities [139].…”

Section: Fig (2)mentioning

confidence: 99%

Flavonoids and Related Compounds in Non-Alcoholic Fatty Liver Disease Therapy

Pisonero-Vaquero¹,

González‐Gallego²,

Sánchez-Campos³

et al. 2015

CMC

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Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome, is one of the most common chronic liver diseases, which may progress to fibrosis, cirrhosis and hepatocellular carcinoma. NAFLD is characterized by the accumulation of lipids in the liver arising from multiple factors: increased fatty acid uptake, increased de novo lipogenesis, reduced fatty acid oxidation and very low density lipoproteins (VLDL) secretion. Most therapeutic approaches for this disease are often directed at reducing body mass index and improving insulin resistance through lifestyle modifications, bariatric surgery and pharmacological treatments. Nevertheless, there is increasing evidence that the use of natural compounds, as polyphenols, exert multiple benefits on the disorders associated with NAFLD. These molecules seem to be able to regulate the expression of genes mainly involved in de novo lipogenesis and fatty acid oxidation, which contributes to their lipid-lowering effect in the liver. Their antioxidant, anti-inflammatory, antifibrogenic and antilipogenic properties seem to confer on them a great potential as strategy for preventing NAFLD progression. In this review, we summarized the effects of these compounds, especially flavonoids, and their mechanisms of action, that have been reported in several studies carried out in in vitro and in vivo models of NAFLD.

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“…Botanicals often contain diverse phytochemicals with multiple mechanisms of action that may have a synergistic effect, which provides greater benefit than a single chemical entity (Graf et al, 2010). Red bayberry, also called Chinese bayberry or Yang-mei, is the fruit of the subtropical evergreen tree Myrica rubra native to China and Southeast Asia, and has been cultured for more than 2000 years in China (Guo et al, 2014). Red bayberry has been traditionally immersed in wine or processed to juice, which is used as a health-promoting beverage in the local region (Liu, …”

Section: Introductionmentioning

confidence: 99%