Effects of BDE-85 on the Oxidative Status and Nerve Conduction in Rodents

Vagula, Mary C.; Kubeldis, Nathan; Nelatury, Charles F.

doi:10.1177/1091581811411109

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…There are reports on rats showing decreased antioxidative enzymes in brain tissue during BDE-99 indicating that not all congeners have the same impact on the tissues. Another observation made by the authors (MCV) is BDE-209 is much less toxic compared to BDE-85 [60].…”

Section: Discussionmentioning

confidence: 84%

Lipid Peroxidation and Polybrominated Diphenyl Ethers – A Toxicological Perspective

Vagula¹,

Konieczko²

2012

Lipid Peroxidation

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Section: Discussionmentioning

confidence: 84%

Lipid Peroxidation and Polybrominated Diphenyl Ethers – A Toxicological Perspective

Vagula¹,

Konieczko²

2012

Lipid Peroxidation

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“…Vagula et al. ( 2011 ) injected BDE‐85 at 0.25 mg/kg bw per day i. p . into adult mice for 4 days and found that markers of oxidative stress were elevated in the liver and brain.…”

Section: Assessmentmentioning

confidence: 99%

Update of the risk assessment of polybrominated diphenyl ethers (PBDEs) in food

Schrenk,

Bignami,

Bodin

et al. 2024

EFS2

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The European Commission asked EFSA to update its 2011 risk assessment on polybrominated diphenyl ethers (PBDEs) in food, focusing on 10 congeners: BDE‐28, ‐47, ‐49, ‐99, ‐100, ‐138, ‐153, ‐154, ‐183 and ‑209. The CONTAM Panel concluded that the neurodevelopmental effects on behaviour and reproductive/developmental effects are the critical effects in rodent studies. For four congeners (BDE‐47, ‐99, ‐153, ‐209) the Panel derived Reference Points, i.e. benchmark doses and corresponding lower 95% confidence limits (BMDLs), for endpoint‐specific benchmark responses. Since repeated exposure to PBDEs results in accumulation of these chemicals in the body, the Panel estimated the body burden at the BMDL in rodents, and the chronic intake that would lead to the same body burden in humans. For the remaining six congeners no studies were available to identify Reference Points. The Panel concluded that there is scientific basis for inclusion of all 10 congeners in a common assessment group and performed a combined risk assessment. The Panel concluded that the combined margin of exposure (MOET) approach was the most appropriate risk metric and applied a tiered approach to the risk characterisation. Over 84,000 analytical results for the 10 congeners in food were used to estimate the exposure across dietary surveys and age groups of the European population. The most important contributors to the chronic dietary Lower Bound exposure to PBDEs were meat and meat products and fish and seafood. Taking into account the uncertainties affecting the assessment, the Panel concluded that it is likely that current dietary exposure to PBDEs in the European population raises a health concern.

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“…Previous work [ 13 ] has shown that PBDEs and their metabolites have influence on adrenosteroid production in H295R adrenocortical cancer cells, but the study on their toxicities and thermal decomposition is restricted. BDE-47 and BDE-85 are the two congeners of PBDEs [ 20 ]. BDE-47 is one of the most common congeners, but has not been examined for carcinogenicity in model systems [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Bioinformatic analyses of hydroxylated polybrominated diphenyl ethers toxicities on impairment of adrenocortical secretory function

Cai

Wei

et al. 2022

Environ Health Prev Med

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Background: Polybrominated diphenyl ethers (PBDEs) and their metabolites have severe impact on human health, but few studies focus on their nephrotoxicity. This study was conceived to explore hub genes that may be involved in two hydroxylated polybrominated diphenyl ethers toxicities on impairment of adrenocortical secretory function. Methods: Gene dataset was obtained from Gene Expression Omnibus (GEO). Principal component analysis and correlation analysis were used to classify the samples. Differentially expressed genes (DEGs) were screened using the limma package in RStudio (version 4.1.0). Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and Reactome enrichment analyses of DEGs were conducted. Protein-protein interaction (PPI) network was established using STRING network, and genes were filtered by Cytoscape (version 3.8.2). Finally, the hub genes were integrated by plug-in CytoHubba and RobustRankAggreg, and were preliminarily verified by the Comparative Toxicogenomics Database (CTD). Results: GSE8588 dataset was selected in this study. About 190 upregulated and 224 downregulated DEGs in 2-OH-BDE47 group, and 244 upregulated and 276 downregulated DEGs in 2-OH-BDE85 group. Functional enrichment analyses in the GO, KEGG and Reactome indicated the potential involvement of DEGs in endocrine metabolism, oxidative stress mechanisms, regulation of abnormal cell proliferation, apoptosis, DNA damage and repair. 2-OH-BDE85 is more cytotoxic in a dose-dependent manner than 2-OH-BDE47. A total of 98 hub genes were filtered, and 91 nodes and 359 edges composed the PPI network. Besides, 9 direct-acting genes were filtered for the intersection of hub genes by CTD. Conclusions: OH-PBDEs may induce H295R adrenocortical cancer cells in the disorder of endocrine metabolism, regulation of abnormal cell proliferation, DNA damage and repair. The screened hub genes may play an important role in this dysfunction.

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Effects of BDE-85 on the Oxidative Status and Nerve Conduction in Rodents

Cited by 6 publications

References 23 publications

Lipid Peroxidation and Polybrominated Diphenyl Ethers – A Toxicological Perspective

Lipid Peroxidation and Polybrominated Diphenyl Ethers – A Toxicological Perspective

Update of the risk assessment of polybrominated diphenyl ethers (PBDEs) in food

Bioinformatic analyses of hydroxylated polybrominated diphenyl ethers toxicities on impairment of adrenocortical secretory function

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