Effects of BDNF and ANK3 in bipolar disorder

Shi, Aike

doi:10.1063/5.0094319

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…The third group is a heterogeneous group of molecules that belong to the cytokine family [153]. In vivo study hypothesized that dysregulation of neurotrophic factors may be involved in the etiology of autism [154], anxiety [155], major depressive disorder (MDD) [156], post-traumatic stress disorder (PTSD) [157], schizophrenia [158], and various neurodegenerative disorders such as PD [159], AD [160], and bipolar disorder (BD) [161]. The stimulation of motor neurons with BDNF may improve motor function in an amyotrophic lateral sclerosis (ALS) model [162].…”

Section: Zingiberaceae Family Plants Modulating Neurotrophic Pathways...mentioning

confidence: 99%

Modulating Effects of Zingiberaceae Phenolic Compounds on Neurotrophic Factors and Their Potential as Neuroprotectants in Brain Disorders and Age-Associated Neurodegenerative Disorders: A Review

et al. 2023

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The Zingiberaceae family possess various phenolic compounds that have significant systemic bioactivities in the brain, including in age-related neurodegenerative diseases. Neurotrophins are growth factors that protect neurons from oxidative stress, and dysregulation of the neurotrophic system may result in neurocognitive disease. Phenolic compounds from the Zingiberaceae family have been used in traditional and complementary medicine (TCM) to improve cognitive functions. These compounds may affect the expression of neurotrophic agents, but their underlying molecular mechanisms require further investigation. Therefore, the goal of this review is to determine the expression and functional roles of phenolic compounds from the Zingiberaceae family in brain disorders and age-related neurodegenerative disorders. While previous studies have proposed various mechanisms for the neuroprotective activity of these compounds, their precise mechanism of action remains complex and poorly understood. Despite some promising findings, there are still shortcomings in the therapeutic use of these herbs, and current interventions involving the Zingiberaceae family appear to be clinically insufficient. This article aims to summarize recent discoveries of phenolic compounds from several Zingiberaceae family members and their use as neuroprotectants and provide the first review of evidence-linked neuroprotective activity of bioactive ingredients from prominent members of the Zingiberaceae family.

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Section: Zingiberaceae Family Plants Modulating Neurotrophic Pathways...mentioning

confidence: 99%

Modulating Effects of Zingiberaceae Phenolic Compounds on Neurotrophic Factors and Their Potential as Neuroprotectants in Brain Disorders and Age-Associated Neurodegenerative Disorders: A Review

et al. 2023

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A Comprehensive Review on Potential Molecular Drug Targets for the Management of Alzheimer's Disease

Sharma,

Mazumder

2024

CNSAMC

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Alzheimer's disease (AD) is an onset and incurable neurodegenerative disorder that has been linked to various genetic, environmental, and lifestyle factors. Recent research has revealed several potential targets for drug development, such as the prevention of Aβ production and removal, prevention of tau hyperphosphorylation, and keeping neurons alive. Drugs that target numerous ADrelated variables have been developed, and early results are encouraging. This review provides a concise map of the different receptor signaling pathways associated with Alzheimer's Disease, as well as insight into drug design based on these pathways. It discusses the molecular mechanisms of AD pathogenesis, such as oxidative stress, aging, Aβ turnover, thiol groups, and mitochondrial activities, and their role in the disease. It also reviews the potential drug targets, in vivo active agents, and docking studies done in AD and provides prospects for future drug development. This review intends to provide more clarity on the molecular processes that occur in Alzheimer's patient's brains, which can be of use in diagnosing and preventing the condition.

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Effects of BDNF and ANK3 in bipolar disorder

Cited by 2 publications

References 23 publications

Modulating Effects of Zingiberaceae Phenolic Compounds on Neurotrophic Factors and Their Potential as Neuroprotectants in Brain Disorders and Age-Associated Neurodegenerative Disorders: A Review

Modulating Effects of Zingiberaceae Phenolic Compounds on Neurotrophic Factors and Their Potential as Neuroprotectants in Brain Disorders and Age-Associated Neurodegenerative Disorders: A Review

A Comprehensive Review on Potential Molecular Drug Targets for the Management of Alzheimer's Disease

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