Effects of bee venom on protease activities and free radical damages in synovial fluid from type II collagen-induced rheumatoid arthritis rats

Suh, Sungho; Kim, Kap‒Sung; Kim, Minjung; Chang, Young‐Chae; Lee, Seung-Duk; Kim, Myung-Sunny; Kwon, Dae Young; Kim, Cheorl-Ho

doi:10.1016/j.tiv.2006.06.016

Cited by 43 publications

(24 citation statements)

References 15 publications

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“…Bee venom (BV) is an alternative medicine that has been widely used in the treatment of some immune-related diseases, especially rheumatoid arthritis [10]. Many studies have shown that BV therapy attenuates rheumatoid arthrits in humans and experimental animals, and that BV has an anti-inflammatory effect [11].…”

Section: Introductionmentioning

confidence: 99%

Bee Venom-Associated Th1/Th2 Immunoglobulin Class Switching Results in Immune Tolerance of NZB/W F1 Murine Lupus Nephritis

Lee

Lee²,

Kim³

et al. 2011

Am J Nephrol

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Background/Aims: Bee venom (BV) therapy has been used to treat inflammatory diseases including rheumatoid arthritis in humans and in experimental animals. This study was conducted to examine the therapeutic effect of BV on established lupus nephritis in New Zealand Black/White (NZB/W) F1 female mice. Methods: Beginning at 18 weeks of age, mice were given a subcutaneous injection of either BV (3 mg/kg BW) or an equal volume of saline once a week until the end of the study. To examine the effect of BV on CD4+CD25+Foxp3+ regulatory T cells, splenocytes from NZB/W mice (23 weeks of age) were treated with BV (1 µg/ml) or PBS in the presence of anti-CD3Ε (1 µg/ml) and anti-CD28 antibodies (4 µg/ml) for 48 h. Results: BV administration delayed the development of proteinuria to a significant extent, prevented renal inflammation, reduced tubular damage, and reduced immune deposits in the glomeruli. Interestingly, CD4+CD25+ regulatory T cells were significantly increased in vitro and in vivo after BV treatment. Conclusion: Collectively, the administration of BV that has immune modulating effects represents an applicable treatment of lupus nephritis in NZB/W F1 mice.

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Section: Introductionmentioning

confidence: 99%

Bee Venom-Associated Th1/Th2 Immunoglobulin Class Switching Results in Immune Tolerance of NZB/W F1 Murine Lupus Nephritis

Lee

Lee²,

Kim³

et al. 2011

Am J Nephrol

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“…The reactivity of hypochlorous acid, O 2 -and vitamin C has a great influence on the function of cartilage, resulting in a reduction in the vitamin C content in joint synovial fluid. Activated phagocytes produce reactive oxygen species, which are able to alter the immunofluorescent properties of immunoglobulin G (IgG), leading to the further activation of phagocyte fluorescent protein polymers (11,12). The degeneration of IgG inhibits rheumatoid factor, directly resulting in the generation of C-reactive protein (12).…”

Section: Discussionmentioning

confidence: 99%

Effective treatment of polydatin weakens the symptoms of collagen-induced arthritis in mice through its anti-oxidative and anti-inflammatory effects and the activation of MMP-9

Wang

2016

Molecular Medicine Reports

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Abstract. Polydatin is a natural extract used in traditional Chinese medicine, which leads to a marked improvement in the microcirculation perfusion and enhances the animal myocardial contraction force. The present study aimed to determine whether an effective treatment of polydatin ameliorates the symptoms of collagen-induced arthritis (CIA), and also to explore the potential mechanism. Male DBA/1J mice were induced into CIA model mice. The administration of polydatin effectively suppressed CIA in mice. The serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), tumor necrosis factor-α (TNF-α) and interleukin 1β (IL-1β) were effectively increased following the induction of CIA in the model mice compared with the control group. The elevated serum levels of MDA, SOD, TNF-α and IL-1β were markedly suppressed by the effective treatment of polydatin in CIA mice, compared with the CIA model group. However, an increase in the level of matrix metalloproteinase-9 (MMP-9) was markedly induced in the CIA mice compared with the control group. As compared with the CIA group, the expression of MMP-9 was substantially reduced by the effective treatment of polydatin. Taken together, the effective treatment of polydatin ameliorated the symptoms of CIA through an exertion of its antioxidative and anti-inflammatory effects, and also via activation of the expression of matrix metalloproteinase-9 (MMP-9) in mice.

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“…The resulting hydration of the allergens triggers the rapid and total discharge of major allergenic proteins. This results in a high local concentration of allergens in the airway epithelium [3]. Proteases from HDM and fungi may activate epithelial cells through the surface receptors, like protease activated receptor or toll-like receptors, resulting in generation of cytokines and facilitating antigen…”

mentioning

confidence: 99%

Bee Venom at Different Concentrations Modulates the Aeroallergen-Induced Activation of Nasal Polyp Epithelial Cells

Shin

Ye²,

Kim³

et al. 2013

Pharmacology

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Bee venom (BV) has long been used as an oriental traditional medicine for the control of pain and inflammation. However, BV’s anti-inflammatory mechanisms remain unclear. This study aimed to clarify the potential clinical efficacy of BV concerning the anti-inflammatory effect on nasal epithelial cell inflammation. Nasal polyp epithelial cells were obtained from patients. Cells were exposed to Alternaria alternata, Aspergillus nigra, Dermatophagoides pteronyssinus, Dermatophagoides farina and lipopolysaccharide with or without various concentrations of BV. Interleukin (IL)-6, IL-8, and granulocyte macrophage colony-stimulating factor were measured to determine the activation of epithelial cells. Nuclear factor-ĸB (NF-ĸB) and activator protein 1 expression and activity were determined with Western blot analysis and ELISA. Cytotoxicity of BV was measured using a CellTiter-96® aqueous cell proliferation assay kit. Cell survival was significantly decreased at BV concentrations exceeding 5 µg/ml. Fungi-induced cytokine production was more effectively inhibited by BV than house dust mite. Alternaria enhanced NF-ĸB expression, which was strongly inhibited by BV. BV appears to be relatively safe, and is of potential value for the treatment of airway inflammation and/or immunologic diseases.

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Effects of bee venom on protease activities and free radical damages in synovial fluid from type II collagen-induced rheumatoid arthritis rats

Cited by 43 publications

References 15 publications

Bee Venom-Associated Th1/Th2 Immunoglobulin Class Switching Results in Immune Tolerance of NZB/W F1 Murine Lupus Nephritis

Bee Venom-Associated Th1/Th2 Immunoglobulin Class Switching Results in Immune Tolerance of NZB/W F1 Murine Lupus Nephritis

Effective treatment of polydatin weakens the symptoms of collagen-induced arthritis in mice through its anti-oxidative and anti-inflammatory effects and the activation of MMP-9

Bee Venom at Different Concentrations Modulates the Aeroallergen-Induced Activation of Nasal Polyp Epithelial Cells

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